Expression of ASK1 during chick and early mouse development

Ferrer-Vaquer, Anna; Maurey, Pablo; Firnberg, Nicole; Leibbrandt, Andreas; Neubüser, Annette

doi:10.1016/j.modgep.2007.05.001

Cited by 8 publications

(4 citation statements)

References 21 publications

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“…Higher mRNA levels were detected in back fat, ileum, kidney, spleen, and liver tissues, whereas lower mRNA levels were observed in lung, pancreas, and stomach tissues. These findings are consistent with those of a previous survey indicating that MAP3K5 is strongly expressed in the condensing nephrogenic mesenchyme of the chicken nephric duct (Ferrer-Vaquer et al, 2007). The spleen is the largest blood filter in the body and combines the innate and adaptive immune systems in a uniquely organized way (Kraal, 1992;Steiniger and Barth, 2000).…”

Section: Ferus)supporting

confidence: 92%

Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake

Zhang

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is essential for apoptosis, proliferation, differentiation, and immune responses, and is a candidate marker for residual feed intake (RFI) in pig. We cloned the full-length cDNA sequence of porcine MAP3K5 by rapid-amplification of cDNA ends. The 5451-bp gene contains a 5'-untranslated region (UTR) (718 bp), a coding region (3738 bp), and a 3'-UTR (995 bp), and encodes a peptide of 1245 amino acids, which shares 97, 99, 97, 93, 91, and 84% sequence identity with cattle, sheep, human, mouse, chicken, and zebrafish MAP3K5, respectively. The deduced MAP3K5 protein sequence contains two conserved domains: a DUF4071 domain and a protein kinase domain. Phylogenetic analysis showed that porcine MAP3K5 forms a separate branch to vicugna and camel MAP3K5. Tissue expression analysis using real-time quantitative polymerase chain reaction (qRT-PCR) revealed that MAP3K5 was expressed in the heart, liver, spleen, lung, kidney, muscle, fat, pancrea, ileum, and stomach tissues. Copy number variation was detected for porcine MAP3K5 and validated by qRT-PCR. Furthermore, a significant increase in average copy number was detected in the low RFI group when compared to the high RFI group in a Duroc pig population. These results provide useful information regarding the influence of MAP3K5 on RFI in pigs.

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Section: Ferus)supporting

confidence: 92%

Porcine MAP3K5 analysis: molecular cloning, characterization, tissue expression pattern, and copy number variations associated with residual feed intake

Zhang

et al. 2016

Genet. Mol. Res.

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“…Although no cardiovascular defects are observed with loss of MEKK5 in development, it may provide additive or even compensatory function to MEKK4, which functions through p38 and JNK as well (Gerwins et al, 1997;Abell et al, 2007). MEKK5 is expressed widely during mouse development including high expression in the myocardium of the embryonic heart (Ferrer-Vaquer et al, 2007). Investigating doubleknockout mice for MEKK4/MEKK5 or MEKK5/MEKK6 will be informative for determining compensatory effects by these related MAP3Ks during development.…”

Section: Mekk5 (Ask1) and Mekk6 (Ask2) (Omim#*602448 *604468)mentioning

confidence: 99%

MAP3Ks as central regulators of cell fate during development

Craig

Stevens

Vaillancourt

et al. 2008

Developmental Dynamics

112

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“…Apoptosis signal-regulating kinase 1 (ASK1) is one such MAP3K, upstream of JNK and p38 kinases; furthermore, ASK1 is preferentially activated by stress stimuli, specifically by oxidative stress (Cuevas et al, 2007). A dynamic and regional-specific expression of ASK1 was recently jpet.aspetjournals.org found in chick and mouse embryos (Ferrer-Vaquer et al, 2007), including the limb region. Mice deficient in ASK1 develop normally, but this may be due to gene redundancy (Tobiume et al, 2001).…”

mentioning

confidence: 99%