Expression of Bcl-2 and MIB-1 Markers in Oral Squamous Cell Carcinoma (OSCC)- A Comparative Study

Analysis of Ki-67 expression as clinicopathological parameters in predicting the prognosis of adenoid cystic carcinoma

“…As a result, when excessive cell proliferation and lack of apoptosis occurs, the tumor will develop. 12,13 In tumors experiencing aggressive growth, there can also be an imbalance between cell production and cell death, in which the former exceeds the latter. The proliferation rate of a tumor is closely related to its biological behavior.…”

“…Up to the present, no research results exist confirming that environmental and genetic factors cause this tumor. However, they do indicate abnormalities in chromosomes 6q, 9p, and 17p of regions [12][13]. There are also frequent genetic deletions in 12q, 13q, and 19q.…”

“…In other words, a tumor can occur as the result of a higher rate of cell proliferation than cell death, resulting in the progression of the tumor. 12,13 Thus, in order to predict the aggressiveness of a tumor, any immunohistochemical examination conducted should employ Ki-67 as an antibody marker. By utilising Ki-67, cell proliferation will be detectable because this antibody will only be expressed under such conditions.…”

Evaluation of BCL-2 Expression in Cigarette Smokers

“…Paired t test power calculation was used to detect the proper sample size. Means and standard deviations were determined according to Garewal et al (11) which showed that the first study group had a mean bcl-2 expression of 9.35 (SD=2.28) and the second group had a mean of 3.56 (SD=0.91). The sample size calculation was based on a mean difference of 1.4 points and a pooled standard deviation of the two means' standard deviations.…”

Immunoexpression of Ki-67 in determining prognosis of oral cavity squamous cell carcinoma

“…So, the treatment is more difficult. 3,4,5 The incidence of oral squamous cell carcinoma (OSCC) most often occurs on the lip inferior, lateral and ventral part of the tongue, floor of the mouth, followed by the posterior part of the soft palate, and tonsils area. Moreover, its treatment failure can cause a recurrence of the tumour.…”