1997
DOI: 10.1016/s0046-8177(97)90129-5
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Expression of bcl-2 oncoprotein in gastrointestinal and uterine carcinomas and their premalignant lesions

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Cited by 57 publications
(27 citation statements)
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“…33 In the current study the expression of Bcl-2 was similar to that described previously, showing a decreasing pattern from normal endometrium to hyperplasia and further to carcinoma. 34 In different malignancies, Bcl-2 is thought to protect cells from apoptotic signals.…”
Section: Discussionsupporting
confidence: 89%
“…33 In the current study the expression of Bcl-2 was similar to that described previously, showing a decreasing pattern from normal endometrium to hyperplasia and further to carcinoma. 34 In different malignancies, Bcl-2 is thought to protect cells from apoptotic signals.…”
Section: Discussionsupporting
confidence: 89%
“…The present findings suggest that cigarette smoking can induce Bcl-2 expression and inhibit apoptosis of cells containing DNA damage and gene mutations, which are caused by highly mutagenic compounds in tobacco smoke. Analysis of Bcl-2 expression in squamous dysplasia and metaplasia of the bronchus, which are considered to be premalignant states of lung cancer, may provide further insights into the present observations [22], since Bcl-2 expression is reported in premalignant lesions of gastrointestinal and uterine carcinomas [23]. …”
Section: Discussionmentioning
confidence: 99%
“…Together with Bcl-2, Bcl-X L is a potent suppressor of cell death overexpressed in a number of tumor types (16). Immune reactivity rates for Bcl-2 in normal glands, metaplasia, adenoma, and adenocarcinoma have been seen to be 0, 77, 38, and 11%, respectively, which suggests Bcl-2 overexpression in premalignant lesions and Bcl-2 repression following malignant conversion, this being responsible for early events in the cancer sequence (17).…”
Section: Genes Involved In Apoptosismentioning
confidence: 99%