Expression of Biological Markers Induced by Ionizing Radiation at the Late Period After Exposure in a Wide Range of Doses

Ilienko, I.; Golyarnik, N A; Lyaskivska, O; Belayev, O A; Bazyka, Dimitry

doi:10.33145/2304-8336-2018-23-331-350

Cited by 10 publications

(5 citation statements)

References 18 publications

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“…29 On the other hand, in comparison to other Category B groups, Group VIII showed the lowest serum TNF-α level, implicating that HD-IR alone cannot be considered an immunosuppressive tool. Earlier investigations have concluded that high and low IR can activate the transcription and the secretion of IL-2, IFN-γ, and TNF-α; 39 nevertheless, this activation appeared stronger with high IR doses than with low IR doses. 40,41…”

Section: Discussionmentioning

confidence: 82%

Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study

Hussien

Rashed

2023

Dose-Response

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During radiotherapy, immune-modulatory effects of radiation doses should be taken into consideration, not only the anti-tumor radiation effects. Thus, our study aimed to study how γ-radiation modulates immune response in comparison to common immune-suppressive/stimulant agents. Animals were divided into two groups. Category A received Echinacea purpura extract (EP) or irradiated at low radiation doses 0, .25 or .5 Gray (Gy), whereas Category B received cyclophosphamide (CP) or irradiated at high radiation doses 1, 2, or 5 Gy. Serum levels of immunological mediators interleukin-10 (IL-10) and tumor necrosis factor (TNF-α), as well as redox-markers malondialdehyde (MDA) and nitric oxide (NO), hemoglobin (Hgb), white and red blood cells (WBCs, RBCs), and platelet counts were assessed following irradiation. Of the immune-stimulant category, .25 Gy dose offered EP-comparable effects in TNF-α, RBCs, Hgb, and platelet counts cases. As for the immune-suppressive category; 5 Gy irradiation dose induced inflammatory/immunosuppressive responses indicated (rise in NO, TNF-α, and IL-10), and an oxidative stress status (increase in serum MDA). However, 5 Gy γ-irradiation was not observed, herein, as a single immunosuppressive agent. To conclude, during radiotherapy, immunological impact(s) of the used radiation doses should be optimized and followed-up closely to assess the risk/benefit of their usage.

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Section: Discussionmentioning

confidence: 82%

Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study

Hussien

Rashed

2023

Dose-Response

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“…Priority data were obtained regarding long-term radiation-induced changes in gene expression and polymorphism, genome instability, and cellular senescence in chronic somatic pathology in persons chronically exposed to a wide range of doses. BCL2, SERPINB9, CDKN2A, STAT3, TP53, MCF2L gene changes have been established [20]. Methods of molecular epidemiology have been introduced in patients with radiation-induced leukemia [21].…”

Section: Resultsmentioning

confidence: 99%

Подходы К Совершенствованию Координации Планирования Научной Тематики И Оценки Ожидаемых Результатов Научных Исследований

Tsymbaliuk¹,

Medvedovska²,

Shekera³

et al. 2021

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Background. Historical analysis of the medical science development around the world proves that its results have always been the driving force for progress, and this process is constantly evolving as research itself. Rapid information technologies development affects priority areas for medical research; advances in biotechnologies, nanotechnologies, molecular genetics, bioinformatics, system biology, nanobiotechnology, proteomics, postgenomic studies; cell technologies lead to further development of lines of research. The use of digital health as a system of information and communication technologies, including blockchain technology, allows to securely store and detail medical information, based on the evidence, effectively influence the quality of medical prescriptions, as well as the quality of care delivery in general. The latest technology in medicine has become 3D-bioprinting, which enabled printing implants, prostheses, parts of organs and tissues. Three-dimensional models of human organs, as well as some artificial tissues got by 3D printing, are used for drug research and testing. The dynamic development of medical science in the world, changes in lines of research in favor of biomedical research and biotechnology, genetic engineering, personalized high-tech medicine prompts domestic researchers to search for new areas, the expected of results of which would be innovative in the European countries, as well as around the world. It is urgent to find ways to effectively coordinate research planning, documents (requests) assessment planning and the implementation effectiveness. The purpose of our study is to analyze the implementation of the recognized prior areas in the world of science, to substantiate approaches for improvement of plannong, taking into account certain priorities, national features and the current situation. Materials and methods. Methods of semantic evaluation of scientific documents, results of PhD theses and research works, methods of bibliosemantic, structural and logical content analysis, descriptiveanalytical modeling were used during the research. Basic reaserches planning and implementation materials in the National Academy of Medical sciences of Ukraine of Ukraine categorized by the priority areas for the national medical science for the last five years, own research endpoints concerning planning and implementation materials evaluation have been used. Results. The article gives an overview of the implemented prior lines for the development of domestic fundamental medical research, in particular in terms of their scientific novelty, theoretical and practical importance, substantiation of the further search in the chosen area. The expediency of applying the expert approach to the evaluation of planning materials and the implementation of scientific research in the world practice with the introduction of scientifically sound evaluation indicators is shown. Conclusions. Developing prior areas for domestic basic research, as well as ensuring effective planning, assessing requests for re...

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“…They found decreased CD4+/CD8+ ratios and increased Tregs in 56% of the studied clean-up workers, especially in those exposed to low doses. Interestingly, the authors showed that the decrease in the level of B cells and activated T cells correlated with the increase in interleukin (IL)-1β levels in individuals exposed to doses below 100 mSv ( Ilienko et al, 2018 ). Oradovskaia et al studied a cohort of clean-up workers who developed different malignant diseases and identified typical immune parameter changes in these people 1–3 years before the manifestation of cancer.…”

Section: Human Biomonitoring and Epidemiological Data On Low Dose Radiation-induced Immunological Changesmentioning

confidence: 99%

Low dose ionizing radiation effects on the immune system

Lumniczky

Impens

Armengol

et al. 2021

Environment International

131

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Ionizing radiation interacts with the immune system in many ways with a multiplicity that mirrors the complexity of the immune system itself: namely the need to maintain a delicate balance between different compartments, cells and soluble factors that work collectively to protect, maintain, and restore tissue function in the face of severe challenges including radiation damage. The cytotoxic effects of high dose radiation are less relevant after low dose exposure, where subtle quantitative and functional effects predominate that may go unnoticed until late after exposure or after a second challenge reveals or exacerbates the effects. For example, low doses may permanently alter immune fitness and therefore accelerate immune senescence and pave the way for a wide spectrum of possible pathophysiological events, including early-onset of age-related degenerative disorders and cancer. By contrast, the so called low dose radiation therapy displays beneficial, anti-inflammatory and pain relieving properties in chronic inflammatory and degenerative diseases. In this review, epidemiological, clinical and experimental data regarding the effects of low-dose radiation on the homeostasis and functional integrity of immune cells will be discussed, as will be the role of immune-mediated mechanisms in the systemic manifestation of localized exposures such as inflammatory reactions. The central conclusion is that ionizing radiation fundamentally and durably reshapes the immune system. Further, the importance of discovery of immunological pathways for modifying radiation resilience amongst other research directions in this field is implied.

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Expression of Biological Markers Induced by Ionizing Radiation at the Late Period After Exposure in a Wide Range of Doses

Abstract: Мета. Визначити біологічні маркери радіаційного ураження у віддаленому періоді після опромінення у широ кому інтервалі доз.

Cited by 10 publications

References 18 publications

Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study

Immuno-Biochemical Impacts of Gamma Irradiation in Male Rats: A Dose-Response Study

Подходы К Совершенствованию Координации Планирования Научной Тематики И Оценки Ожидаемых Результатов Научных Исследований

Low dose ionizing radiation effects on the immune system

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