Expression of Bmi1, FoxF1, Nanog, and γ-Catenin in Relation to Hedgehog Signaling Pathway in Human Non-small-Cell Lung Cancer

Gialmanidis, Ioannis P.; Bravou, Vasiliki; Petrou, Ilias; Kourea, Helen P.; Mathioudakis, Alexander G.; Lilis, Ioannis; Papadaki, Helen

doi:10.1007/s00408-013-9490-4

Cited by 31 publications

(24 citation statements)

References 43 publications

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“…High expression of Nanog promotes the epithelial-mesenchymal transition (EMT) [37], which is an important developmental process for cancer cells to obtain stem cell characteristics. Nanog has also been associated with poor prognosis in breast [38], colorectal [39, 40], gastric [41], lung [42, 43], ovarian [44] and liver cancers [45]. …”

Section: Introductionmentioning

confidence: 99%

Stemness-related markers in cancer

2017

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Cancer stem cells (CSCs), with their self-renewal ability and multilineage differentiation potential, are a critical subpopulation of tumor cells that can drive tumor initiation, growth, and resistance to therapy. Like embryonic and adult stem cells, CSCs express markers that are not expressed in normal somatic cells and are thus thought to contribute towards a ‘stemness’ phenotype. This review summarizes the current knowledge of stemness-related markers in human cancers, with a particular focus on important transcription factors, protein surface markers and signaling pathways.

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Section: Introductionmentioning

confidence: 99%

Stemness-related markers in cancer

2017

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“…In lung cancer, FOXF1 enhances the tumor-promoting properties of cancer-associated fibroblasts [97]. FOXF1 may contribute to hedgehog-associated tumorigenesis [98] because its levels are up-regulated in patched-associated tumors like basal cell carcinoma (BCC), medulloblastoma (MB), rhabdomyosarcoma (RMS), and non-small cell lung cancer (NSCLC) [99-101]. FOXF1 target genes Bmi1 and Notch2 were up-regulated in PTCH1-associated BCC and MB, further confirming its key role in hedgehog-associated tumorigenesis.…”

Section: Introductionmentioning

confidence: 99%

Genomic and Epigenetic Complexity of the FOXF1 Locus in 16q24.1: Implications for Development and Disease

Dharmadhikari

Szafrański²,

Kalinichenko

et al. 2015

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The FOXF1 (Forkhead box F1) gene, located on chromosome 16q24.1 encodes a member of the FOX family of transcription factors characterized by a distinct forkhead DNA binding domain. FOXF1 plays an important role in epithelium-mesenchyme signaling, as a downstream target of Sonic hedgehog pathway. Heterozygous point mutations and genomic deletions involving FOXF1 have been reported in newborns with a lethal lung developmental disorder, Alveolar Capillary Dysplasia with Misalignment of Pulmonary Veins (ACDMPV). In addition, genomic deletions upstream to FOXF1 identified in ACDMPV patients have revealed that FOXF1 expression is tightly regulated by distal tissue-specific enhancers. Interestingly, FOXF1 has been found to be incompletely paternally imprinted in human lungs; characterized genomic deletions arose de novo exclusively on maternal chromosome 16, with most of them being Alu-Alu mediated. Regulation of FOXF1 expression likely utilizes a combination of chromosomal looping, differential methylation of an upstream CpG island overlapping GLI transcription factor binding sites, and the function of lung-specific long non-coding RNAs (lncRNAs). FOXF1 knock-out mouse models demonstrated its critical role in mesoderm differentiation and in the development of pulmonary vasculature. Additionally, epigenetic inactivation of FOXF1 has been reported in breast and colorectal cancers, whereas overexpression of FOXF1 has been associated with a number of other human cancers, e.g. medulloblastoma and rhabdomyosarcoma. Constitutional duplications of FOXF1 have recently been reported in congenital intestinal malformations. Thus, understanding the genomic and epigenetic complexity at the FOXF1 locus will improve diagnosis, prognosis, and treatment of ACDMPV and other human disorders associated with FOXF1 alterations.

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“…Although the role of BMI1 and the related network has been studied extensively in recent years, data regarding BMI1 in tumor biology is far from complete. Especially, a specific mechanism for its dysregulation in cancers has not been determined 50. Therefore, much effort is still needed to characterize the complete molecular details, in order to lay the foundation for transition medicine from the experimental findings to potential clinical applications in EOC.…”

Section: Future Challengesmentioning

confidence: 99%

B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer

Zhao

Gui

Qian³

et al. 2016

OTT

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Epithelial ovarian cancer, a vexing challenge for clinical management, still lacks biomarkers for early diagnosis, precise stratification, and prognostic evaluation of patients. B-cell-specific Moloney murine leukemia virus integration site 1 (BMI1), a member of the polycomb group of proteins, engages in diverse cellular processes, including proliferation, differentiation, senescence, and stem cell renewal. In addition, BMI1, as a cancer stem-cell marker, participates in tumorigenesis through various pathways. Rewardingly, recent studies have also revealed a relationship between BMI1 expression and the clinical grade/stage, therapy response, and survival outcome in a majority of human malignancies, including epithelial ovarian cancer. Therefore, BMI1 might serve as a potential stratification factor and treatment target for epithelial ovarian cancer, pending evidence from further investigations.

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Expression of Bmi1, FoxF1, Nanog, and γ-Catenin in Relation to Hedgehog Signaling Pathway in Human Non-small-Cell Lung Cancer

Abstract: Several developmental pathways seem to be implicated in non-small-cell lung cancer. It is also suggested that Bmi1 and FoxF1 may cooperate with hedgehog signaling in non-small-cell lung carcinogenesis.

Cited by 31 publications

References 43 publications

Stemness-related markers in cancer

Stemness-related markers in cancer

Genomic and Epigenetic Complexity of the FOXF1 Locus in 16q24.1: Implications for Development and Disease

B-cell-specific Moloney murine leukemia virus integration site 1: potential stratification factor and therapeutic target for epithelial ovarian cancer

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