Expression of bone morphogenetic protein-15 in human oocyte and cumulus granulosa cells primed with recombinant follicle-stimulating hormone followed by human chorionic gonadotropin

Abnormal expression of growth differentiation factor 9 and bone morphogenetic protein 15 in stimulated oocytes during maturation from women with polycystic ovary syndrome

“…In human beings, their expression was examined only in follicles of early stages, demonstrating an increase with the follicular development from primordial to small antral follicles (5). In this study, the expression levels of both GDF9 and BMP15 were decreased during maturation from GV to MI, which was inconsistent with the results by Chen et al (18). The main changes in oocytes of the MI stage should be the breakdown of nucleus and the resumption of meiosis, which may alter the expression levels of various cytokines.…”

Extra- and intra-ovarian factors in polycystic ovary syndrome: impact on oocyte maturation and embryo developmental competence

“…GDF-9 and BMP-15 (also called as GDF-9b) are two closely related members of the TGF-β family of proteins and are highly expressed in growing and full grown oocytes (Teixeira Filho et al ., 2002; Gilchrist et al ., 2008; Chen et al ., 2009). BMP-15 and GDF-9 play fundamental roles in regulating CC functions through the processes of mitosis, proliferation, apoptosis, luteinization, metabolism and expansion through mitogenic signaling transduction mechanisms (Erickson and Shimasaki, 2001; Teixeira Filho et al ., 2002; van der Spuy and Dyer, 2004; Gilchrist et al ., 2008; Chen et al ., 2009).…”

“…BMP-15 and GDF-9 play fundamental roles in regulating CC functions through the processes of mitosis, proliferation, apoptosis, luteinization, metabolism and expansion through mitogenic signaling transduction mechanisms (Erickson and Shimasaki, 2001; Teixeira Filho et al ., 2002; van der Spuy and Dyer, 2004; Gilchrist et al ., 2008; Chen et al ., 2009). Data from in vitro models demonstrate that co-incubation of COC with either BMP-15 or GDF-9 substantially promotes oocyte maturation and enhances blastocyt production, as well as increases the total number of cells in the trophectoderm (Hussein et al ., 2006) and inner cell mass of mouse embryos (Yeo et al ., 2008).…”

Granulosa Theca Cell Tumor in An Arabian Mare: Are Immunohistochemically Loss of GDF-9 and BMP-6 Proteins Associated with High GATA-4, Inhibin-α, AMH Expressions?

“…The oocyte plays an important role in growth and diff erentiation of the follicle and in directing its own fate 19 . Gene expression profiles of GTCTs in women found to be similar to that of granulosa cells of preantral and small/ medium antral follicles 14 .…”

“…Follicles with high BMP-6 expression may be more likely to survive FSH decrease in serum and to reach dominant follicle stage 20 . GDF-9 is an oocyte-derived factor which plays important roles in primordial follicle recruitment, granulosa and theca cell proliferation/atresia, steroidogenesis, oocyte maturation, ovulation, luteinization, and corpus luteum formation 19 . GDF-9 promotes follicular growth and synergistically inhibits FSH-induced granulosa cell diff erentiation in primates, ruminants and rodents.…”