Expression of both oestrogen receptor alpha and beta in human skeletal muscle tissue

Wiik, Anna; Ekman, Martin; Johansson, Ӧlle; Jansson, Eva; Esbjörnsson, Mona

doi:10.1007/s00418-008-0512-x

Cited by 156 publications

(115 citation statements)

References 45 publications

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“…Skeletal muscle is expected to be a target tissue for estrogens because two ER isoforms are expressed in skeletal muscle (6). In the present study, E2 induced USP19 expression in vitro and in vivo, and E2-induced USP19 inhibited myogenesis.…”

Section: Discussionmentioning

confidence: 47%

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17β-Estradiol Represses Myogenic Differentiation by Increasing Ubiquitin-specific Peptidase 19 through Estrogen Receptor α

Ogawa

Yamaji

Higashimura

et al. 2011

Journal of Biological Chemistry

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Section: Discussionmentioning

confidence: 47%

“…For example, ER␣ promotes cell proliferation in the development of the reproductive tract and mammary gland, whereas ER␤ seems to have potent antiproliferative (3,4) and anti-inflammatory properties (5). Recently, ER␣ and ER␤ have been identified in skeletal muscle (6). Therefore, estrogens seem to act on skeletal muscle through ER isoforms.…”

mentioning

confidence: 99%

17β-Estradiol Represses Myogenic Differentiation by Increasing Ubiquitin-specific Peptidase 19 through Estrogen Receptor α

Ogawa

Yamaji

Higashimura

et al. 2011

Journal of Biological Chemistry

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“…In addition to the study design, methodology and study group, the dose and duration of HRT usage, and the time between menopause and data collection may be very important variables. In this study the self-reported mean time from menopause was 7.0 (range [3][4][5][6][7][8][9][10][11][12][13] years in the non-users and 8.3 (range 3-19) years in the HRT users with mean of 6.8 years (range 2-16) on the treatment.…”

Section: Discussionmentioning

confidence: 82%

“…Especially, the notion that both estrogen receptors are expressed in human skeletal muscle cells of both genders [7][8] , implies that muscle is a target tissue for estrogen signaling. Estrogen has also been suggested to preserve type II muscle fibers in a study performed on ovariectomized rats 9 .…”

Section: Introductionmentioning

confidence: 99%

Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy

et al. 2011

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Introduction: Postmenopausal monozygotic twin pairs discordant for hormone replacement therapy (HRT) provide an advantageous study design controlling for genetic background for elucidating the relationships between aging, sex hormone levels, muscle strength, contractile capacity, and fatigability. Methods: Thirteen postmenopausal monozygotic twin pairs discordant for HRT were measured for maximal voluntary torque (MVC) and twitch characteristics using electrical stimulation before and after intermittent dynamic plantarflexor exercise until exhaustion. Results: Peak twitch torque was 32% higher in HRT users than in their non‐HRT, genetically identical sisters (P = 0.002), but MVC did not differ. There were no differences in the activation level or twitch time characteristics between the co‐twins. Fatigue caused decreases in MVC (P = 0.001), twitch torque (P = 0.001), time to peak (P = 0.013), and half‐relaxation time (P = 0.001) similarly in HRT users and non–HRT users. Conclusion: In early postmenopausal women, involuntary but not voluntary force‐generating mechanisms of the plantarflexors are augmented by the use of HRT. Muscle Nerve, 2011

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“…ER␣ and ER␤ have been identified at the protein level by immunohistochemistry and was found to be localized to the nuclei of both muscle fibers and endothelial cells (35)(36)(37). ERs in myoblasts appear to be functional when stimulated with estrogen (20), and estrogen stimulation increases expression of insulin-like growth factor (IGF-1) in both myotubes and proliferating myoblasts (21).…”

mentioning

confidence: 99%

Activation of estrogen response elements is mediated both via estrogen and muscle contractions in rat skeletal muscle myotubes

Wiik¹,

Hellsten²,

Berthelson³

et al. 2009

American Journal of Physiology-Cell Physiology

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Wiik A, Hellsten Y, Berthelson P, Lundholm L, Fischer H, Jansson E. Activation of estrogen response elements is mediated both via estrogen and muscle contractions in rat skeletal muscle myotubes. Am J Physiol Cell Physiol 296: C215-C220, 2009. First published November 19, 2008 doi:10.1152/ajpcell.00148.2008The aim of the present study was to investigate the activation of estrogen response elements (EREs) by estrogen and muscle contractions in rat myotubes in culture and to assess whether the activation is dependent on the estrogen receptors (ERs). In addition, the effect of estrogen and contraction on the mRNA levels of ER␣ and ER␤ was studied to determine the functional consequence of the transactivation. Myoblasts were isolated from rat skeletal muscle and transfected with a vector consisting of sequences of EREs coupled to the gene for luciferase. The transfected myoblasts were then differentiated into myotubes and subjected to either estrogen or electrical stimulation. Activation of the ERE sequence was determined by measurement of luciferase activity. The results show that both ER␣ and ER␤ are expressed in myotubes from rats. Both estrogen stimulation and muscle contraction increased (P Ͻ 0.05) transactivation of the ERE sequence and enhanced ER␤ mRNA, whereas ER␣ was unaffected by estrogen and attenuated (P Ͻ 0.05) by muscle contraction. Use of ER antagonists showed that, whereas the estrogen-induced transactivation is mediated via ERs, the effect of muscle contraction is ER independent. The muscle contraction-induced transactivation of ERE and increase in ER␤ mRNA were instead found to be MAP kinase (MAPK) dependent. This study demonstrates for the first time that muscle contractions have a similar functional effect as estrogen in skeletal muscle myotubes, causing ERE activation and an enhancement in ER␤ mRNA. However, in contrast to estrogen, the effect is independent of ERs and dependent on MAPK, suggesting activation via the estrogen related receptor (ERR). electrostimulation; estrogen-related receptor; ligand-independent activity; luciferase; mRNA ESTROGEN RECEPTORS (ERs) are ligand-activated transcription factors that belong to the nuclear hormone receptor super family. Estrogen, which exerts its effect via ERs, is not only a female reproductive hormone but acts almost ubiquitously in the human body and is involved in physiological and pathological states in both males and females. Estrogen has many important effects on the cardiovascular, reproductive, and central nervous system as well as for bone maintenance (14). In skeletal muscle, it has been reported that estrogen for example is involved in regulating carbohydrate and lipid metabolism (22). During exercise, estrogen modifies the energetic substrate mobilization improving fat oxidation while sparing muscle glycogen (22). Previous reports indicate a role of estrogen in muscle growth and strength development (31) but available data are not consistent (13).The two estrogen receptors ER␣ and ER␤ are expressed at the mRNA level in human skeletal mu...

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Expression of both oestrogen receptor alpha and beta in human skeletal muscle tissue

Cited by 156 publications

References 45 publications

17β-Estradiol Represses Myogenic Differentiation by Increasing Ubiquitin-specific Peptidase 19 through Estrogen Receptor α

17β-Estradiol Represses Myogenic Differentiation by Increasing Ubiquitin-specific Peptidase 19 through Estrogen Receptor α

Muscle function in monozygotic female twin pairs discordant for hormone replacement therapy

Activation of estrogen response elements is mediated both via estrogen and muscle contractions in rat skeletal muscle myotubes

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