Expression of c‐erbB2 and p53 protein is similar in breast cancer from British and Japanese women

Merchant, W.; Millis, Rosemary R.; Smith, Paul; Chaudary, M. A.; Barnes, Diana M.

doi:10.1002/(sici)1097-0215(19990621)84:3<278::aid-ijc14>3.0.co;2-#

Cited by 18 publications

(15 citation statements)

References 20 publications

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“…20,21 In contrast to these results, several studies have reported that the proportion of tumors expressing p53 proteins was similar among the ethnic groups (whites, African Americans, Hispanics, and Asians) in the U.S. 8,16 Merchant et al also were unable to find any dissimilarity between British women and Japanese women. 22 The similar pattern of p53 expression between Korean women and white women in our study is consistent with those results.…”

Section: 7-9supporting

confidence: 91%

“…Those authors found similar rates of expression in both populations. 22 Some reports of HER-2/neu expression in Asian women also have noted an incidence of positivity similar to that seen in Western women. 39 Other studies, however, have found a higher incidence of HER-2/neu positivity (approximately 50%) in Japanese women, who are related ethnically to the Korean population.…”

Section: 30mentioning

confidence: 81%

“…In the literature, although some data show correlations between biologic markers and lymph node metastasis, 22,28 others show no correlation.…”

Section: 7-9mentioning

confidence: 98%

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A comparison of five immunohistochemical biomarkers and HER‐2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early‐onset breast carcinoma

Choi

Shin

Lee

et al. 2003

Cancer

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BACKGROUNDThe objective of this article was to compare five tumor markers between white women in the U.S. and native Korean women with early‐onset breast carcinoma.METHODSSixty Korean women who were diagnosed with breast carcinoma at age 45 years or younger and 60 white women with breast carcinoma who were matched by age were selected for this study. The median age of both groups was 37 years. Paraffin embedded blocks of the primary tumor were processed for immunohistochemical staining of estrogen receptor (ER), progesterone receptor (PR), p53, cyclin D1, and HER‐2/neu.RESULTSThe proportion of tumors that stained positive for ER, PR, p53, and cyclin D1 in the Korean women were 47.5%, 42.4%, 28.8%, and 40.9%, respectively; in the white women, the proportions were 43.9%, 52.6%, 21.1%, and 59.1%, respectively. The differences between the white patients and the Korean patients were not statistically significant with respect to any of those variables. A significant difference was found in the expression of HER‐2/neu. Specifically, positive HER‐2/neu status was observed in 47.5% of Korean women, compared with overexpression in only 15.8% of white women (P < 0.001). Fluorescence in situ hybridization analysis for HER‐2/neu gene amplification on all HER‐2/neu positive samples that scored 2 + and 3 + demonstrated a significant difference (P = 0.007) in gene amplification between the two populations. Differences in HER‐2/neu positivity were observed for the entire cohort as well as among the subsets of patients with negative and positive lymph node status. No association was found between immunoreactivity for the five markers and axillary lymph node metastasis.CONCLUSIONSThe findings of high positivity of HER‐2/neu expression and gene amplification in Korean women with early‐onset breast carcinoma may have potential implications for local and systemic management of breast carcinoma, especially anti‐HER‐2/neu therapy for patients with hormone receptor negativity. Further research will be needed to identify biologic and genetic factors and their effects on the survival between different racial groups. Cancer 2003. © 2003 American Cancer Society.DOI 10.1002/cncr.11703

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Section: 7-9supporting

confidence: 91%

Section: 30mentioning

confidence: 81%

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A comparison of five immunohistochemical biomarkers and HER‐2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early‐onset breast carcinoma

Choi

Shin

Lee

et al. 2003

Cancer

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“…Only other study showed that the difference in survival was restricted to postmenopausal patients (Sakamoto et al, 1981). Age-adjusted mortality rates in England and Wales started to decrease in the late 1980s (Beral et al, 1995), while those in Japan have gradually increased, but still lower than the former rates (Tominaga and Kuroishi, 1995; The Research Group for Population-based Cancer Registration in Japan, 2003) As there has been a gradual improvement in survival in British patients, the magnitude of survival differences reported in this study was not nearly as great as that reported in a previous study (Merchant et al, 1999). Improved survival from this cancer in the UK may be due to increased social interest, advances in diagnosis according to the NHS Breast Screening Programme, and development of adjuvant endocrine therapy and chemotherapy (Beral et al, 1995;Kobayashi, 2004).…”

Section: Discussioncontrasting

confidence: 47%

“…Improved survival from this cancer in the UK may be due to increased social interest, advances in diagnosis according to the NHS Breast Screening Programme, and development of adjuvant endocrine therapy and chemotherapy (Beral et al, 1995;Kobayashi, 2004). There is also strong evidence to suggest a population-dependent variation in the biology of breast cancer, such as ER status, p53 gene mutation, HER-2/neu, S-phase fraction, lymphatic infiltration, sinus histiocytosis, and certain histological patterns (Sakamoto et al, 1981;Friedel et al, 1991;Elledge et al, 1994;Merchant et al, 1999). Differences in these biologic characteristics do not explain the relatively high survival rate of Japanese breast cancer patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer

et al. 2007

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The purpose of this study is to investigate the associations of microvessel density (MVD) and other pathological variables with survival, and whether they accounted for survival differences between Japanese and British patients. One hundred seventy-three Japanese and 184 British patients were included in the study. British patients were significantly older (56.3±11.4 years vs 52.5±12.9 years; Po0.01) and had smaller tumours (2.2 ± 1.3 vs 2.7 ± 1.8 cm; Po0.01), which were more frequently oestrogen receptor positive (78.8 vs 57.2%, Po0.01), had more grade III tumours (29.9 vs 21.4%, P ¼ 0.04) and more infiltrating lobular carcinomas (13.6 vs 4.0%, Po0.01) and a higher MVD compared with Japanese patients (57.9±19.8 vs 53.2±18.6; P ¼ 0.01). However, no difference in the prevalence of lymph-node metastasis was found between them (39.1 vs 37.5%, P ¼ 0.75). Younger British patients (age o50 years) had the highest MVD compared with Japanese and older British patients (Po0.01). Japanese patients were proportionately more likely to receive chemotherapy than endocrine therapy (Po0.01). British patients had a significantly worse relapse-free survival and overall survival compared with Japanese patients, after statistical adjustment for variables (hazard ratio ¼ 2.1, 2.4, Po0.01, Po0.01, respectively), especially, in T2 stage, low MVD and older subgroup (HR: 3.6, 5.0; 3.1, 3.3; 3.2, 3.9, respectively), but only in ER negative cases (P ¼ 0.04, P ¼ 0.01, respectively). The present study shows that MVD contributes to the Japanese -British disparity in breast cancer. However, the MVD variability did not explain the survival differences between Japanese and British patients.

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Distinct prognostic values ofp53 mutations and loss of estrogen receptor and their cumulative effect in primary breast cancers

et al. 2000

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Expression of c‐erbB2 and p53 protein is similar in breast cancer from British and Japanese women

Cited by 18 publications

References 20 publications

A comparison of five immunohistochemical biomarkers and HER‐2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early‐onset breast carcinoma

A comparison of five immunohistochemical biomarkers and HER‐2/neu gene amplification by fluorescence in situ hybridization in white and Korean patients with early‐onset breast carcinoma

Prognostic significance of microvessel density and other variables in Japanese and British patients with primary invasive breast cancer

Distinct prognostic values ofp53 mutations and loss of estrogen receptor and their cumulative effect in primary breast cancers

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