Expression of calcium-binding proteins in the mouse claustrum

Real, M. Ángeles; Dávila, José Carlos; Guirado, Salvador

doi:10.1016/s0891-0618(02)00104-7

Cited by 66 publications

(108 citation statements)

References 26 publications

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“…As outlined above, an apparent disproportion in numbers of CR-IR neurons was found between the chinchilla's Cl and EN. In the chinchilla EN, CR-expressing neurons statistically outnumbered those present in Cl, which is in line with previous reports obtained in the mouse (Real et al 2003) and rat (Edelstein et al 2010). Interestingly, in other species including the rabbit , monkey (Reynhout and Baizer 1999) and humans (Prensa et al 2003), a higher percentage of CR-IR neurons was detected in Cl than EN.…”

Section: Discussionsupporting

confidence: 92%

“…So far, at least several distribution patterns of CR-expression in EN neurons have been noted in different animal species. In the mouse Cl, CR-expressing neurons were evenly distributed throughout the nucleus (Real et al 2003), which closely resembles the pattern presented in this study in the chinchilla. However, in the rat CR-IR neurons detected both in Cl and EN were predominantly localized in close neighborhood to the insular cortex (Druga 2014).…”

Section: Discussionsupporting

confidence: 86%

“…Only in the cat, did both parts of the claustrum contain relatively low and proportional numbers of CR-expressing neurons (Rahman and Baizer 2007). Similarly to previous results presented in the mouse (Real et al 2003), rat (Druga 2014) and rabbit ) single CR-IR neurons found in the chinchilla's Cl were localized in the marginal zone of the insula. On the other hand in the cat (Rahman and Baizer 2007) and monkey (Reynhout and Baizer 1999), CR-expressing neurons were evenly scattered throughout Cl.…”

Section: Discussionsupporting

confidence: 84%

“…In general, the pattern presented above is in line with results obtained in most animal species studied, excluding the mouse and rat. In Cl of the latter animal species, CR-IR neurons were predominantly categorized as medium-sized multipolar, oval and fusiform in shape (Druga 2014, Real et al 2003. In the rat Cl and EN, the larger diameter of CR-IR neurons present in the rat Cl and EN is substantially larger when compared to the moderate parameters measured in the chinchilla (respectively 13.7 ± 0.3 μm and 8.4 ± 1.2 μm in Cl and 15.6 ± 0.3 μm and 11.0 ± 1.1 μm in EN).…”

Section: Discussionmentioning

confidence: 99%

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Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Szalak¹,

Matysek²,

Mozel³

et al. 2015

Polish Journal of Veterinary Sciences

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Calretinin (CR) as a buffer and sensor protein plays an important role in regulatory processes of Ca 2+ and anty-apoptotic cellular protection. In the present study, immunohistochemical peroxidase-antiperoxidase (PAP) method was used in order to determine the numbers, morphology, morphometry and distribution pattern of CR in neurons of the chinchilla's claustrum (Cl) and endopiriform nucleus (EN). In Cl and EN the presence of several classes of neurons with different immunoreactivity to CR was found. In Cl, CR-immunoreactive (IR) neurons were predominantly found in close vicinity to insular border while CR-IR neurons were evenly scattered throughout EN. In general, immunoreaction to CR was observed in neuronal cytoplasm, nucleus and in fibres-like nerve extensions. Statistical analysis showed the differences between average large diameter as well as cross-sectional area of CR-IR neurons present in Cl and EN. It is suggested, that CR acting as a calcium binding protein may play a role in neuronal network. Further co-localization studies are necessary to fully elucidate neurophysiology and neuropathology of the chinchilla's Cl and EN neurons.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 86%

Section: Discussionsupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

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Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Szalak¹,

Matysek²,

Mozel³

et al. 2015

Polish Journal of Veterinary Sciences

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“…In some species complementarity of immunoreactivity for parvalbumin (Pv) and calretinin (Cr) has been observed in the insular claustrum, with a strongly Pv immunoreactive region corresponding in position within the insular claustrum to a Cr immunonegative region [Druga et al, 1993;Paxinos et al, 1999;Real et al, 2003]. Conversely, calretinin immunoreactive neurons are present in the endopiriform nucleus where parvalbumin neurons are few or absent [Paxinos et al, 1999].…”

Section: Introductionmentioning

confidence: 99%

The Claustrum Is Not Missing from All Monotreme Brains

2004

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Many authors have reported that the claustrum, which comprises the insular claustrum and the endopiriform nucleus, is missing from the monotreme forebrain. We used Nissl and myelin staining in conjunction with enzyme histochemistry for acetylcholinesterase and immunohistochemistry for parvalbumin, calbindin, calretinin and tyrosine hydroxylase to examine the brains of two monotremes, the short-beaked echidna (Tachyglossus aculeatus) and the platypus (Ornithorhynchus anatinus). We found that although the insular claustrum is a small structure in the echidna brain, it is nevertheless clearly present as loosely clustered neurons embedded in the white matter ventrolateral to the putamen and deep to the piriform and entorhinal cortices. Neurons in this region share the chemical features of the adjacent cortex (presence of a similar proportion of parvalbumin immunoreactive neurons and minimal activity for acetylcholinesterase and tyrosine hydroxylase), unlike the adjacent putamen and ventral pallidum. A putative endopiriform nucleus can be identified in the interior of the piriform lobe of the echidna as calretinin immunoreactive neurons embedded within the white matter. The situation is much less clear in the platypus, but our data suggest that there may be an insular claustrum deep to frontal cortex, separated from layer VI by only a thin layer of white matter. We could not identify an endopiriform nucleus in our platypus material. Our findings indicate that presence of the claustrum cannot be considered a feature confined to therian mammals and lend weight to arguments that this structure was present in the ancestral mammalian brain.

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The Claustrum in the Squirrel Monkey

Baizer

Webster

Baker

2019

The Anatomical Record

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The claustrum (CLA) is a subcortical structure that is reciprocally and topographically connected with the cerebral cortex. The complexity of the cerebral cortex varies dramatically across mammals, raising the question of whether there might also be differences in CLA organization, circuitry, and function. Species variations in the shape of the CLA are well documented. Studies in multiple species have identified subsets of neurochemically distinct interneurons; some data suggest species variations in the nature, distribution, and numbers of different neurochemically identified neuronal types. We have studied the CLA in a smooth-brained primate, the squirrel monkey, using Nissl-stained sections and immunohistochemistry. We found that the shape of the CLA is different from that in other primates. We found several different neurochemically defined populations of neurons equally distributed throughout the CLA. Immunoreactivity to GAD 65/67 and GABA A receptors suggest that GABAergic interneurons provide widespread inhibitory input to CLA neurons. Immunoreactivity to glutamate transporters suggests widespread and overlapping excitatory input from cortical and possibly subcortical sources. Comparison of CLA organization in different species suggests that there may be major species differences both in the organization and in the functions of the CLA.

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Expression of calcium-binding proteins in the mouse claustrum

Cited by 66 publications

References 26 publications

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

Immunocytochemical detection of calretinin in the claustrum and endopiriform nucleus of the chinchilla

The Claustrum Is Not Missing from All Monotreme Brains

The Claustrum in the Squirrel Monkey

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