Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Donato, Daniel P.; Johnson, Matthew T.; Yang, Ximing J.; Zynger, Debra L.

doi:10.1111/j.1365-2559.2011.04074.x

Cited by 32 publications

(26 citation statements)

References 40 publications

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“…This result is consistent with the study of Donato et al (28), where choriocarcinoma tumors were predominately negative in CA IX. In contrast to the results published by Donato et al (28), the present study detected CA IX expression not only in teratomas and embryonal carcinomas, but also in seminomas and in yolk sac tumors. On the other hand we identified no CA IX expression in germ cell neoplasia in situ .…”

Section: Discussionsupporting

confidence: 93%

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors

et al. 2017

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Testicular germ cell tumors (TGCTs) represent a highly curable malignancy, however a small proportion of patients fails to be cured with cisplatin-based chemotherapy. Carbonic anhydrase IX (CA IX) is upregulated by hypoxia in several cancer types and correlates with a poor prognosis. The present translational study evaluated expression and prognostic value of CA IX in TGCTs. Surgical specimens from 228 patients with TGCTs were processed by the tissue microarray method and subjected to immunohistochemistry with the M75 monoclonal antibody. CA IX expression was evaluated in tumors vs. adjacent normal testicular tissues and correlated with clinicopathological characteristics and clinical outcome. CA IX expression was detected in 62 (30.2%) of TGCTs compared to 0 (0%) of normal tissue adjacent to testicular tumor (P<0.001). The highest frequency of the CA IX expression was detected in teratoma (39.0%), followed by seminoma (22.7%), yolk sac tumor (22.2%), embryonal carcinoma (11.9%) and choriocarcinoma (7.7%). None of germ cell neoplasias in situ (GCNIS) exhibited CA IX expression. Patients without the CA IX tumor expression showed significantly better progression-free survival, but not overall survival, compared to patients with the CA IX expression [hazard ratio (HR), 0.57; 95% CI, 0.32–1.02; P=0.037 and HR, 0.58; 95% CI, 0.29–1.16; P=0.088, respectively]. There was no significant correlation between the CA IX expression and clinicopathological variables. The intratumoral CA IX expression can serve as a prognostic marker in the TGCT patients. These results suggest that activation of the hypoxia-induced pathways may be important in the treatment failure in TGCTs patients.

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Section: Discussionsupporting

confidence: 93%

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors

et al. 2017

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“…Contrary to RCCC, however, the high levels of CA IX are, almost always, associated with advanced stage and/or high grade of tumors and, often, with their poor prognosis (Table 1 ). This was the case for our series of 11 cases of high-grade, invasive bladder cancers that, according to previous reports, were found extensively immune-reactive for the protein [73, 106, 110, 136] (Fig. 5d ).…”

Section: Immunohistochemical Expression Of Ca IX In Human Solid Cancerssupporting

confidence: 82%

“…Prostate adenocarcinomas resulted, frequently, non-expressing CA IX, according to what previously reported by Donato DP and coll. [106-108]. However, in several cases, we found either an epithelial expression of the protein in neoplastic glands, with a frequent membrane signal reinforcement, (Fig.…”

Section: Immunohistochemical Expression Of Ca IX In Human Solid Cancersmentioning

confidence: 71%

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Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers

Ilardi¹,

Zambrano²,

Merolla³

et al. 2014

CMC

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Intrinsic and acquired drug resistance of tumor cells still causes the failure of treatment regimens in advanced human cancers. It may be driven by intrinsic tumor cells features, or may also arise from micro environmental influences. Hypoxia is a microenvironment feature associated with the aggressiveness and metastasizing ability of human solid cancers. Hypoxic cancer cells overexpress Carbonic Anhydrase IX (CA IX). CA IX ensures a favorable tumor intracellular pH, while contributing to stromal acidosis, which facilitates tumor invasion and metastasis. The overexpression of CA IX is considered an epiphenomenon of the presence of hypoxic, aggressive tumor cells. Recently, a relationship between CA IX overexpression and the cancer stem cells (CSCs) population has been hypothesized. CSCs are strictly regulated by tumor hypoxia and drive a major non-mutational mechanism of cancer drug-resistance. We reviewed the current data concerning the role of CA IX overexpression in human malignancies, extending such information to the expression of the stem cells markers CD44 and nestin in solid cancers, to explore their relationship with the biological behavior of tumors. CA IX is heavily expressed in advanced tumors. A positive trend of correlation between CA IX overexpression, tumor stage/grade and poor outcome emerged. Moreover, stromal CA IX expression was associated with adverse events occurrence, maybe signaling the direct action of CA IX in directing the mesenchymal changes that favor tumor invasion; in addition, membranous/cytoplasmic co-overexpression of CA IX and stem cells markers were found in several aggressive tumors. This suggests that CA IX targeting could indirectly deplete CSCs and counteract resistance of solid cancers in the clinical setting.

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“…Ретроспективный анализ материа-ла больных СКК выявил гиперэкспрессию мРНК CA9 в 97% наблюдений, при этом отмечена тен-денция к ее уменьшению со снижением степени дифференцировки опухоли от G1 к G4 [25]. Эти данные коррелируют с результатами иммуно-гистохимических исследований, где экспрессия CA9 выявлена почти во всех случаях [26].…”

Section: методы анализаunclassified

Expression Profiles and Methylation Genes in Clear Cell Renal Carcinoma

et al. 2016

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Рак почки -часто встречающееся онкологическое заболевание мочеполовой системы, самой распро-страненной формой которого является светлоклеточ-ная карцинома. В большинстве случаев диагностика заболевания и оценка его прогноза основываются на данных инструментальных методов обследования. Между тем остается актуальным поиск и характери-стика новых молекулярных маркеров рака почки. В основе канцерогенеза рака почки лежат молеку-лярно-генетические нарушения, сопровождающиеся изменением экспрессии генов, однако диагностиче-ские панели экспрессионных маркеров опухолей по-чек в рутинной клинической практике пока не имеют широкого использования. В обзоре представлены результаты исследований последних лет в области экспрессионных генетических маркеров рака почки с целью формирования прогностических тест-систем. Применение методологии NotI-микрочипов позволи-ло идентифицировать множество новых генов, свя-занных с патогенезом заболевания. Выявлена связь изменений уровня экспрессии и метилирования ге-нов хромосомы 3 с прогрессией рака почки и мета-стазированием. На основе этих данных предложена диагностическая система маркеров рака почки по идентификации профилей экспрессии, метилирова-ния, а также новых генов, что представляет актуаль-ную задачу современной онкоурологии. Кушлинский Николай Евгеньевич -д-р мед. наук, профессор, член-корреспондент РАН, заведующий кафедрой клинической биохимии и лабораторной диагностики 6 * 115478, Москва, Каширское шоссе, 24, Российская Федерация. Тел.: +7 (499) 324 11 69. E-mail: biochimia@mtu-net.ru В общей структуре онкологических за-болеваний в России злокачествен-ные новообразования почек относят-ся к числу наиболее частых опухолей. Среди мужчин в возрасте от 30 до 59 лет рак почки занимает 4-е место после рака легко-го, кожи и желудка [1]. Около 95% всех случаев рака почки представлены почечно-клеточными карциномами, остальные 5% -опухолями по-чечной лоханки и мочеточника. Ежегодно в мире регистрируется 270 тысяч новых случаев почеч-но-клеточной карциномы и 116 тысяч смертей от этого заболевания, что позволяет отнести его к одной из важнейших проблем онкоурологии.Известно, что почечно-клеточная карцино-ма представляет гетерогенную группу опухолей

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Expression of carbonic anhydrase IX in genitourinary and adrenal tumours

Cited by 32 publications

References 40 publications

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors

Prognostic value of intratumoral carbonic anhydrase IX expression in testicular germ cell tumors

Histopathological Determinants of Tumor Resistance: A Special Look to the Immunohistochemical Expression of Carbonic Anhydrase IX in Human Cancers

Expression Profiles and Methylation Genes in Clear Cell Renal Carcinoma

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