Expression of Caspase-3 Predicts Prognosis in Advanced Noncardia Gastric Cancer

Amptoulach, Sousana; Lazaris, Anthoula; Karadima, Maria L.; Boulamatsis, Dimitrios; Kavatzas, Nikolaos; Patsouris, E.; Tsavaris, N.

doi:10.1093/annonc/mdu334.46

Cited by 4 publications

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“…However, the high expression of CASP3 in some tumors has also attracted attention. [40-43] Upregulation of CASP3 expression in GBM in this study is not a rare event. Recent studies suggest that CASP3 protein has a nonapoptotic effect and promotes tumor recurrence and angiogenesis.…”

Section: Discussionmentioning

confidence: 68%

Network pharmacology-based screening of the active ingredients and mechanisms of evodiae fructus anti-glioblastoma multiforme

Hao²,

Liu³

et al. 2022

Medicine

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Background: Evodiae fructus has been shown to have anti-glioblastoma multiforme (GBM) effects. However, its anti-GBM active components and mechanism remain unclear. In this study, the active components of evodiae fructus were screened by network pharmacology to explore the possible molecular mechanism of resistance to GBM. Materials and methods: The main active ingredients of evodiae fructus were derived from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and Batch-traditional Chinese medicine (TCM). TCMSP and Swiss absorption, distribution, metabolism and elimination (ADME) predict genetic targets for ingredients that meet pharmacological criteria. GBM-related targets were obtained from DisGeNet, GeneCards, Online Mendelian Inheritance in Man (OMIM), Therapeutic Target Database (TTD), and TCGA. A Venn diagram was used to obtain the common targets of evodiae fructus and GBM. Protein–protein interaction (PPI) networks and component-disease target networks were constructed using Cytoscape 3.8.1 software for visualization. GBM gene differential expression was visualized by VolcaNoseR, and potential targets were enriched by Gene Ontology (GO) function and annotated by the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway by SRplot. Molecular docking verification was conducted using AutoDock Vina software. Results: According to the screening conditions, 24 active components and 80 drug targets were obtained. The PPI network contains 80 proteins. The molecular docking verification showed the molecular docking affinity of the core active compounds in evodiae fructus with CASP3, JUN, EGFR, and AKT1. Conclusions: This study preliminarily identified the various molecular targets and multiple pathways of evodiae fructus against GBM.

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Section: Discussionmentioning

confidence: 68%

Network pharmacology-based screening of the active ingredients and mechanisms of evodiae fructus anti-glioblastoma multiforme

Hao²,

Liu³

et al. 2022

Medicine

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“…As indicated in previous reports, high Casp3 expression might simply reflect high turnover of cancer cells, i.e. the aggressiveness of tumors 16,21,22,24,26 . Indeed, high Casp3 expression correlated with high Ki67 expression in our dataset.…”

Section: Possible Reasons For Patients With High Casp3 Tumors Having ...mentioning

confidence: 66%

“…The relationship between Casp3 expression and patient prognosis remains unclear, though several studies have focused on this putative relationship [15][16][17][18] . While high Casp3 expression was reported to be related to a good prognosis for several diseases such as colon cancer and Burkitt's lymphoma 15,17,19,20 , it is a poor prognostic factor for other cancers 16,21,22 . Furthermore, only a few studies have examined the relationship between Casp3 and breast cancer outcomes and these results are not yet conclusive [22][23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

Activated Caspase 3 Expression in Remnant Disease After Neoadjuvant Chemotherapy May Predict Outcomes of Breast Cancer Patients

et al. 2016

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“…Caspase enzymes are cysteine proteases that have responsibility for initiating and executing phases of apoptotic cell death. Several reports indicated that up-regulation of mRNA for caspase-3 positively correlates with cell apoptosis [30][31][32]. Therefore, in this study, we evaluated the apoptosis process via studying the Bcl2 (apoptosis inhibitor) to BAX (apoptosis promoter) ratio along with caspase-3 expression in various treatment regimens.…”

Section: Discussionmentioning

confidence: 99%

Effect of celecoxib and cisplatin combination on apoptosis and cell proliferation in a mouse model of chemically-induced colonic aberrant crypt foci

Essawy

Bilasy

Mohammad

et al. 2017

Egyptian Journal of Basic and Applied Sciences

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2017) Effect of celecoxib and cisplatin combination on apoptosis and cell proliferation in a mouse model of chemically-induced colonic aberrant crypt foci, Egyptian Journal of Basic and Applied Sciences, 4:4, 323-331, a b s t r a c tThe use of cisplatin for the treatment of cancer is accompanied by dose-dependent adverse effects. In colorectal cancer, there is upregulation of cyclooxygenase-2 (COX-2) expression increases prostaglandin E2 (PGE2) which in turn depresses apoptosis and potentiates invasion, angiogenesis, cell-proliferation and metastasis. This study investigates a possible synergistic function for celecoxib in cisplatin-based chemotherapy against chemically-induced colon carcinogenesis in mice. Mice received fifteen injections of 1,2-dimethylhydrazine dihydrochloride (DMH; 20 mg/kg/week, s.c.) to induce colon carcinogenesis and the normal control group received equal volumes of normal saline. Mice were randomly divided into five groups, (I) normal control group, (II) DMH control group (III) DMH + cisplatin (4 mg/kg/week, i.p.) group, (IV) DMH + celecoxib (10 mg/kg/day by gavage) group and (V) DMH + cisplatin + celecoxib group. Drugs were administered starting from week eleven until the end of the experiment (week 15). Colon specimens were used to evaluate histological grades, examine intratumoral expression of Bcl2, BAX and caspase-3 and the number of proliferating nuclei. The combination of cisplatin and celecoxib was effective against malignant transformation in mice with DMH-induced colonic aberrant crypt foci (ACF). The combination group showed improvement in histological grading, the highest caspase-3 expression and the lowest Bcl2/BAX ratio and reduction by approximately 50% of immunoreactivity for proliferating cell nuclear antigen (PCNA) compared to DMH control group. Addition of celecoxib to cisplatin regimen promotes apoptosis, suppresses tumor proliferation and augments the antitumor effect of cisplatin chemotherapy in the mouse model of DMH-induced ACF. Ó 2017 Production and hosting by Elsevier B.V. on behalf of Mansoura University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Expression of Caspase-3 Predicts Prognosis in Advanced Noncardia Gastric Cancer

Cited by 4 publications

References 0 publications

Network pharmacology-based screening of the active ingredients and mechanisms of evodiae fructus anti-glioblastoma multiforme

Network pharmacology-based screening of the active ingredients and mechanisms of evodiae fructus anti-glioblastoma multiforme

Activated Caspase 3 Expression in Remnant Disease After Neoadjuvant Chemotherapy May Predict Outcomes of Breast Cancer Patients

Effect of celecoxib and cisplatin combination on apoptosis and cell proliferation in a mouse model of chemically-induced colonic aberrant crypt foci

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