Expression of cathepsin D in head and neck cancer

Zeillinger, Robert; Swoboda, Herwig; Machacek, E; Nekahm, D.; Sliutz, Gerhard; Knogler, W.; Speiser, Paul; Swoboda, E; Kubista, E.

doi:10.1016/0959-8049(92)90533-8

Cited by 26 publications

(12 citation statements)

References 7 publications

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“…Cathepsin D values are shown in Figure2. The difference between the medians for tumour tissue (27 pmol/mg, n=50), and for normal tissue (12pmol/mg, n=50) is significant (P < 0.001) and the results are close to those of Zeillinger et al (1992) who reported means for tumour and normal tissue values of 34.5 pmol/mg and 13.7 pmol/mg, respectively.…”

Section: Resultssupporting

confidence: 79%

“…The association of different biological agents with this disease, including proteases (Zeillinger et a/., 1992;Mueller et a/., 1991;Pollete et a/., 1991), has been studied intensively in an attempt to understand the pathogenesis of these tumours and to evaluate their potential applicability for prognosis and therapy.…”

Section: Resultsmentioning

confidence: 99%

“…In squamous cell carcinoma, which is the most common malignancy of head and neck, the expression of cathepsin D has been examined previously (Zeillinger et a/., 1992). Its concentration was found to be significantly higher in primary tumours and lymph node metastases than in adjacent normal tissue.…”

Section: Introductionmentioning

confidence: 99%

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Lysosomal Proteases Cathepsins D, B, H, L and Their Inhibitors Stefins A and B in Head and Neck Cancer

Kos¹,

Šmid²,

Krašovec³

et al. 1995

Biological Chemistry Hoppe-Seyler

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In cytosols of tumour and normal tissue of 53 patients suffering from head and neck carcinoma cathepsins D, B, H and L were measured using quantitative immunoreactive assays (ELISA). The values of cathepsins D, B and L were significantly higher in tumour tissue, whereas cathepsin H concentration was lower in tumour than in normal tissue. Median cathepsin D values were 27 pmol (tumour tissue) vs. 12 pmol (normal tissue) per mg of total protein, median cathepsin B values were 1.25 micrograms/mg (tumour tissue) vs. 0.23 micrograms/mg (normal tissue) and median cathepsin L values were 39.8 ng/mg (tumour tissue) vs. 20.0 ng/mg (normal tissue). Median cathepsin H values were 1.05 micrograms/mg and 2.20 micrograms/mg for tumour and normal tissue, respectively. Additionally, stefin A and stefin B were measured in tumour and normal tissue samples. In contrast to the cathepsins, the concentrations of these inhibitors of cysteine proteinases was not significantly different between tumour and normal samples. The concentrations of cathepsins D, B, H and L and stefins A and B measured in head and neck tumours, were independent of standard clinical and histological prognostic factors. Significant correlation of tumour tissue values was observed between cathepsins B and L and between both stefins.

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Section: Resultssupporting

confidence: 79%

Section: Resultsmentioning

confidence: 99%

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Lysosomal Proteases Cathepsins D, B, H, L and Their Inhibitors Stefins A and B in Head and Neck Cancer

Kos¹,

Šmid²,

Krašovec³

et al. 1995

Biological Chemistry Hoppe-Seyler

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“…The presence of higher enzyme concentrations in tumor tissue was in accordance with the results of other authors, as were the ratios of their tumor to normal tissue concentrations [6,8,14]. However, tumor concentrations of cathepsin B or D did not correlate with any of the clinicohistological char-S153 acteristics under study or prognosis, even though cathepsin D is recognized as prognostically important in clinical oncology [13].While not statistically significant, lower DFS and DSS rates were associated with higher concentrations (equal to or above cut-off values) of cathepsins B and D.…”

Section: Time (Months)supporting

confidence: 92%

Prognostic value of cathepsins B, D and stefins A and B in laryngeal carcinoma

Šmid¹,

Strojan

Budihna

et al. 1997

Eur Arch Otorhinolaryngol

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Concentrations of cathepsins A, D and stefins A and B were measured in primary tumor and adjacent normal tissue of 25 patients with laryngeal carcinoma. Median concentrations of both cathepsins and that of stefin B were significantly higher in tumor tissue than in their normal counterparts (cathepsins B and D, P < 0.0001; stefin B, P = 0.01), indicating their possible involvement in the process of tumor spread. Early (T1 and T2) tumors had lower concentrations of stefins A and B than locally advanced (T3 and T4) tumors (P = 0.04). Disease-free and disease-specific survival rates at 45 months were significantly better in patients with tumor concentrations of stefins above or equal to the cut-off values (stefin A, P = 0.001 and P = 0.004; stefin B, P = 0.048 and P = 0.008), indicating that these might be of prognostic value. The concentrations of cathepsins B and D did not correlate with survival.

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“…cesses in vivo has still not been provided, a consistent bulk of clinical studies have shown that this enzyme is highly expressed, in terms of mass and/or catalytic activity concentrations, in tumour cells and tissues of a number of human neoplastic diseases as compared to their normal counterpart and that these levels may correlate, in some cases, with the malignant progression of these tumours (7)(8)(9)(10)(11)(12)(13). In this context several studies have also shown increased cathepsin D catalytic activity concentrations in human liver tumours as compared to normal liver tissues (14) as well elevated plasma mass concentrations of this enzyme in patients with malignant and non-malignant liver diseases as compared to healthy subjects (15).…”

mentioning

confidence: 99%

Cathepsin D Serum Mass Concentrations in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis

Leto¹,

Tumminello²,

Pizzolanti³

et al. 1996

CCLM

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Cathepsin D serum mass concentrations were determined by enzyme immunoassay in patients with hepatocellular carcinoma (n = 51) and/or liver cirrhosis (n = 92) or benign steatosis (n = 16) and correlated with some biochemical and clinical properties of these diseases. Increased cathepsin D serum mass concentrations (P < 0.001) were observed in all these groups of patients as compared to normal subjects (n = 98). However, patients with steatosis had serum mass concentrations of this enzyme significantly lower (mean 2-3 fold) than those measured in cancer patients (P < 0.05) or cirrhotic patients (P < 0.001). Interestingly, significantly higher cathepsin D serum mass concentrations (mean + 62%) (P < 0.006) were determined in the cirrhosis group as compared to cancer patients. No correlation between cathepsin D and a number of clinical and biochemical properties examined, namely, α-foetoprotein, number of neoplastic lesions and tumour size in cancer patients or, ChildPugh grade of severity of cirrhosis and other enzymes of liver function tests in the cirrhotic group was found. The present data and those from other studies which indicate that cathepsin D may be involved in carcinogenesis suggest that this enzyme may be potentially useful as an additional biochemical marker to identify cirrhotic patients who may develop precancerous hepatic nodules.

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Expression of cathepsin D in head and neck cancer

Cited by 26 publications

References 7 publications

Lysosomal Proteases Cathepsins D, B, H, L and Their Inhibitors Stefins A and B in Head and Neck Cancer

Lysosomal Proteases Cathepsins D, B, H, L and Their Inhibitors Stefins A and B in Head and Neck Cancer

Prognostic value of cathepsins B, D and stefins A and B in laryngeal carcinoma

Cathepsin D Serum Mass Concentrations in Patients with Hepatocellular Carcinoma and/or Liver Cirrhosis

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