Expression of CCL1 and CCL18 in atopic dermatitis and psoriasis

Kim, H. O.; Cho, Soo Ick; Chung, Bo Young; Ahn, Hye Kyung; Park, C. W.; Lee, C. H.

doi:10.1111/j.1365-2230.2011.04295.x

Cited by 35 publications

(32 citation statements)

References 14 publications

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“…This is in agreement with the finding showing that TNF-α induces the expression of CCL1 in macrophages [43]. Taking into account recent reports demonstrating elevated CCL1 expression is atopic dermatitis [42,44] our results may provide an additional explanation for the successful application of anti-TNF-α therapy in atopic dermatitis [40]: by targeting TNF-α the downstream expression of CCL1 is decreased attenuating thereby the initiation and amplification of atopic skin inflammation. …”

Section: Resultssupporting

confidence: 92%

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

et al. 2013

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Activation of dendritic cells by different pathogens induces the secretion of proinflammatory mediators resulting in local inflammation. Importantly, innate immunity must be properly controlled, as its continuous activation leads to the development of chronic inflammatory diseases such as psoriasis. Lipopolysaccharide (LPS) or peptidoglycan (PGN) induced tolerance, a phenomenon of transient unresponsiveness of cells to repeated or prolonged stimulation, proved valuable model for the study of chronic inflammation. Thus, the aim of this study was the identification of the transcriptional diversity of primary human immature dendritic cells (iDCs) upon PGN induced tolerance. Using SAGE-Seq approach, a tag-based transcriptome sequencing method, we investigated gene expression changes of primary human iDCs upon stimulation or restimulation with Staphylococcus aureus derived PGN, a widely used TLR2 ligand. Based on the expression pattern of the altered genes, we identified non-tolerizeable and tolerizeable genes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (Kegg) analysis showed marked enrichment of immune-, cell cycle- and apoptosis related genes. In parallel to the marked induction of proinflammatory mediators, negative feedback regulators of innate immunity, such as TNFAIP3, TNFAIP8, Tyro3 and Mer are markedly downregulated in tolerant cells. We also demonstrate, that the expression pattern of TNFAIP3 and TNFAIP8 is altered in both lesional, and non-lesional skin of psoriatic patients. Finally, we show that pretreatment of immature dendritic cells with anti-TNF-α inhibits the expression of IL-6 and CCL1 in tolerant iDCs and partially releases the suppression of TNFAIP8. Our findings suggest that after PGN stimulation/restimulation the host cell utilizes different mechanisms in order to maintain critical balance between inflammation and tolerance. Importantly, the transcriptome sequencing of stimulated/restimulated iDCs identified numerous genes with altered expression to date not associated with role in chronic inflammation, underlying the relevance of our in vitro model for further characterization of IFN-primed iDCs.

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Section: Resultssupporting

confidence: 92%

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

et al. 2013

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“…38,39 The expression of I-309 is significantly high in the acute lesional skin of AD patients. 40 Th1-related chemokine IP-10 executes a powerful chemotactic action on activated lymphocytes toward inflammatory sites, particularly during infection. 15 The chemoattractant GRO-a can trigger neutrophil and Tlymphocyte chemotaxis, particularly after tissue damage.…”

Section: Discussionmentioning

confidence: 99%

Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes

Chang

Lin

Kuo

et al. 2016

Journal of Microbiology, Immunology and Infection

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“…As shown previously, various chemokines are highly expressed † Contributed equally to the research. in AD on both mRNA and/or protein level [9][10][11][12][13][14][15] . However, data on in vivo levels of various cytokines/chemokines in chronic AD skin are scarce.…”

Section: Introductionmentioning

confidence: 99%

Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin

Szegedi

Lutter

Res

et al. 2015

Acad Dermatol Venereol

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Expression of CCL1 and CCL18 in atopic dermatitis and psoriasis

Abstract: CCL1 is a chemokine that is associated with AD. Both CCL1 and CCL18 may play important roles in the initiation and progression of atopic skin inflammation.

Cited by 35 publications

References 14 publications

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

Genome Wide Transcriptome Analysis of Dendritic Cells Identifies Genes with Altered Expression in Psoriasis

Tacrolimus suppresses atopic dermatitis-associated cytokines and chemokines in monocytes

Cytokine profiles in interstitial fluid from chronic atopic dermatitis skin

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