Expression of CCR6 on B cells in systemic lupus erythematosus patients

Lee, Adrian Y S; Bannan, Jennifer; Adams, Murray J.; Körner, Heinrich

doi:10.1007/s10067-017-3652-3

Cited by 12 publications

(12 citation statements)

References 16 publications

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“…Although the major B-cell subsets were found not to differ between SLE patients and HCs, CCR6 was found to be more prominently expressed on B cells of SLE patients compared with HCs. 66 This is in contrast to a previous study that did not establish any difference between CCR6 across B cells and their subsets. 67 Diagnostic utility of CCR6-CCL20 in SLE The search for biomarkers for diagnosis, prognosis and monitoring treatment remains a significant part of medical research in diseases.…”

Section: B Cellscontrasting

confidence: 88%

“…CCR6 and CCL20 may assist with positioning T FH and B cells at the T-B cell border and contributing to the "quality" of the T-B cell synapse. 8 The role of the possible raised CCR6 on B-cell subsets in SLE patients 66 remains a mystery at this stage. However, Elgueta et al 75 have shown that CCR6 expression on memory B cells remains important for proper localization and function of these cells in lymphoid organs, and CCR6 has been identified as a marker of B cells undergoing memory B-cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

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CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

Lee

Körner

2020

Immunol Cell Biol

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The CC chemokine receptor 6 (CCR6) and its sole chemokine ligand, CCL20, are an intriguing pair that have been implicated in a growing number of inflammatory, autoimmune and malignant disease processes. Recent observations have also highlighted this chemokine axis in the regulation of humoral immune responses. Through this review article, we explore the emerging links of CCR6-CCL20 with an archetypal autoimmune disease of humoral dysregulation: systemic lupus erythematosus (SLE). CCR6 is expressed prominently on several immune cells involved in the pathogenesis of SLE, such as dendritic cells and T-helper 17 cells. CCR6's expression is correlated with disease activity and serological markers of disease severity, suggesting a possible role in disease pathogenesis. However, there are numerous holes in our understanding of the functions of CCR6 and CCL20, and future studies are required to determine if there are any diagnostic, prognostic or monitoring roles for these important molecules.

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Section: B Cellscontrasting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

Lee

Körner

2020

Immunol Cell Biol

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“…Here, viSNE maps from patients and controls did not show the same pattern, suggesting a reorganisation of B cell subpopulations after septic shock. To further investigate this observation, cells were coloured on viSNE plots according to cell surface expression of CD38 or CCR6, two markers of B cell differentiation 13 . We observed that, in both healthy donors and septic shock patients, CD38 + and CCR6 + cells did not present same location on the viSNE map, indicating that they belonged to different cell subtypes.…”

Section: Resultsmentioning

confidence: 99%

Proof of concept study of mass cytometry in septic shock patients reveals novel immune alterations

Gossez¹,

Rimmelé²,

Andrieu³

et al. 2018

Sci Rep

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Innovative single cell technologies such as mass cytometry (CyTOF) widen possibilities to deeply improve characterisation of immune alterations mechanisms in human diseases. So far, CyTOF has not been used in sepsis – a condition characterized by complex immune disorders. Here, we evaluated feasibility of CyTOF analysis in patients with septic shock. We designed a mass cytometry panel of 25 extracellular markers to study mononuclear cells from 5 septic shock patients and 5 healthy donors. We explored single-cell data with global and specific unsupervised approaches such as heatmaps, SPADE and viSNE. We first validated relevance of our CyTOF results by highlighting established immune hallmarks of sepsis, such as decreased monocyte HLA-DR expression and increased expressions of PD1 and PD-L1 on CD4 T cells and monocytes. We then showed that CyTOF analysis reveals novel aspects of sepsis-induced immune alterations, e.g. B cell shift towards plasma cell differentiation and uniform response of several monocyte markers defining an immune signature in septic patients. This proof of concept study demonstrates CyTOF suitability to analyse immune features of septic patients. Mass cytometry could thus represent a powerful tool to identify novel pathophysiological mechanisms and therapeutic targets for immunotherapy in septic shock patients.

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“…IGHM is down-regulated in colorectal cancer and idiopathic pulmonary fibrosis (Yang et al, 2012;Pentheroudakis et al, 2015). CCR6 is highly expressed in the B cells of SLE patients (Lee et al, 2017) and colon cancer patients (Kapur et al, 2016); RASGRP3 is highly expressed in breast cancer (Nagy et al, 2012), glioblastoma (Lee et al, 2015), prostate cancer (Zeng et al, 2014), uveal melanoma (Chen et al, 2017) and other malignant carcinomas. Overall, key genes are both age-related and disease-related and are expressed differentially relative to varying health conditions in the aging process.…”

Section: Discussionmentioning

confidence: 99%

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans

et al. 2018

Genes Genet. Syst.

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Human lifespan is determined by genetic and environmental factors. Potential longevity genes are neither specific nor reproducible, and longevity-related genes are constantly confused with age-related genes. To distinguish specific age-and longevity-related genes, we analyzed a Gene Expression Omnibus (GEO) dataset established by the Leiden Longevity Study. The individuals were classified into longevity (mean age, 93.4 ± 3.0 years), longevity offspring (60.8 ± 6.1) and control (61.9 ± 6.9) groups. The series matrix files were downloaded, and average expression values were calculated. Differentially expressed genes (DEGs) between longevity and control groups and those between longevity and their offspring were identified by GEO2R online. A total of 507 longevity-and 755 age-related DEGs were visualized using a Venn diagram. Weighted gene co-expression network analysis (WGCNA) was performed on the longevity-and age-related DEGs. Agerelated color modules and genes were identified. However, no longevity-related modules or genes were found. The green module, with 46 age-related DEGs, was the most biologically significant to age and aging. Gene Ontology, Kyoto Encyclopedia of Genes and Genomes, and protein-protein interaction pathway analyses were conducted on these 46 DEGs, which are mainly enriched in B cell activation and receptor signaling pathways. CR2, VPREB3, MS4A1 and CCR6 were considered the most crucial candidate genes for aging.

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Expression of CCR6 on B cells in systemic lupus erythematosus patients

Cited by 12 publications

References 16 publications

CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

CC chemokine receptor 6 (CCR6) in the pathogenesis of systemic lupus erythematosus

Proof of concept study of mass cytometry in septic shock patients reveals novel immune alterations

Age-related but not longevity-related genes are found by weighted gene co-expression network analysis in the peripheral blood cells of humans

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