Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon

Sato, Yuki; Itoh, Fumio; Hinoda, Yuji; Ohe, Yasuo; Nakagawa, Naoaki; Ueda, Ryuzo; Yachi, Akira; Imai, Kohzoh

doi:10.1007/bf01211181

Cited by 83 publications

(54 citation statements)

References 24 publications

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“…Besides hematopoietic tissue, various benign and malignant nonhematopoietic tissues were also found to express CD10. [5][6][7][8][9][10] CD10 is known to regulate biological activities of peptide substrates by reducing the local concentrations available for receptor binding and signal transduction.…”

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confidence: 99%

CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression

et al. 2004

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CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues including melanomas. It was recently shown that metastatic melanomas express more CD10 than primary tumors. We evaluated CD10 expression in tumor and stromal cells in 70 biopsies with primary and 28 with metastatic malignant melanomas. Ki-67, Bcl-2, and Bax were also examined to investigate whether CD10 expression is associated with tumor proliferation index or factors of apoptosis. Formalin-fixed/paraffin-embedded tissues were studied by immunohistochemistry. More advanced primary tumors had higher CD10 expression in the tumor cells (r ¼ 0.27, P ¼ 0.03 for Clark levels and r ¼ 0.29, P ¼ 0.02 for Breslow) and higher Ki-67 proliferation fraction (r ¼ 0.32, P ¼ 0.007 for Clark levels and r ¼ 0.32, P ¼ 0.001 for Breslow). Similarly, CD10 expression in the intratumoral stromal cells was also higher in primary tumors with higher Clark level (P ¼ 0.04, linear-by-linear association) and tumor thickness according to Breslow (r ¼ 0.33, P ¼ 0.01). The presence of CD10 þ peritumoral stromal cell cuffs was also positively associated with tumor thickness according to Breslow (r ¼ 0.27, P ¼ 0.05). Also, expression of CD10 and Ki-67 were significantly higher in metastatic than in primary tumors (P ¼ 0.01 and 0.02 respectively), but Bcl-2 expression was higher in primary melanomas (P ¼ 0.02). We conclude that CD10 expression in malignant melanoma is associated with tumor progression.

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confidence: 99%

CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression

et al. 2004

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“…Sato et al 1 identified a higher expression of CD10 in colorectal carcinomas well or moderately differentiated and a lower expression in poorly differentiated neoplasms. Fujimoto et al 10 observed that the expression of CD10 was higher in well differentiated tumors when compared to the others.…”

Section: Discussionmentioning

confidence: 99%

“…This event is believed to be related to neoplastic progression 2 . Studies have identified a difference in marker expression in tumors and non-neoplastic colorectal mucosa adjacent to the tumor 1,13,14 . Ogawa et al 15 studied the expression of CD10 in tumor tissue of colorectal carcinoma and did not find any expression of this marker in samples of non-neoplastic mucosa adjacent to the tumor.…”

Section: Discussionmentioning

confidence: 99%

“…Later, it was identified in liver cell, breast and neoplasm cell of the large bowel 1,2 . It is a 100 kDa glycoprotein, with strong expression in the brush border of the intestinal epithelium, germinal centers of lymph node follicles and liver microvilli.…”

Section: Introductionmentioning

confidence: 99%

“…It is a 100 kDa glycoprotein, with strong expression in the brush border of the intestinal epithelium, germinal centers of lymph node follicles and liver microvilli. Studies [1][2][3] have associated this marker with the appearance of liver metastasis, venous invasion and progression of these tumors to more advanced stages in patients with colorectal neoplasm.…”

Section: Introductionmentioning

confidence: 99%

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Tissue expression of CD10 protein in colorectal carcinoma: correlation with the anatomopathological features of the tumor and with lymph node and liver metastases

Oliveira¹,

Neto²,

Netto³

et al. 2012

J. Coloproctol. (Rio J.)

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Tissue expression of CD10 protein in colorectal carcinoma: correlation with the anatomopathological features of the tumor and with lymph node and liver metastases. J Coloproctol, 2012;32(1): 34-9. AbstrACt: background:The reduced expression of CD10 may be related to unfavorable prognosis of patients with colorectal carcinoma. The authors analyzed the tissue immunostaining of CD10 protein in colorectal carcinoma and its relationship to clinicopathologic features. Method: In 130 patients submitted to colorectal carcinoma surgery, a tissue microarray block was obtained from the tumor and adjacent non-neoplastic mucosa and submitted to immunohistochemistry with monoclonal antibody CD10. The immunostaining was evaluated by semi-quantitative method, with stained cell count in percentage. The results were related to the location, anatomopathological features, presence of lymph node and hepatic metastases and TNM staging of the colorectal neoplasm. The statistical analysis was performed with the Mann-Whitney, Kruskal-Wallis and Fisher exact tests. results: The expression of CD10 marker was higher in colorectal tumor tissue than in adjacent non-neoplastic mucosa (p<0.0001) and was higher than in exophytic lesions (p=0.04). The expression of CD10 protein was not associated with other clinical and pathological aspects of colorectal neoplasm. Conclusions: The expression of CD10 protein was more intense in tumor tissue of colorectal carcinoma than in adjacent non-neoplastic mucosa and was related to the exophytic appearance of the tumor.Keywords: neoplasm antigens; colorectal neoplasms; prognosis; neoplasm metastasis; CD10 antigens. resuMO: Introdução: A expressão reduzida de CD10 pode estar relacionada com prognóstico desfavorável de doentes com carcinoma colorretal. Analisou-se a imunoexpressão tecidual da proteína CD10 no carcinoma colorretal e sua relação com os aspectos clinicopatológicos. Método: Em 130 doentes operados por carcinoma colorretal, um bloco de tissue microarray foi obtido do tecido neoplásico e da mucosa não neoplásica adjacente e submetido ao estudo imuno-histoquímico com anticorpo monoclonal CD10. Avaliou-se a imunoexpressão por método semiquantitativo, com contagem do percentual de células coradas. Os resultados foram relacionados com a localização, aspectos anatomopatológicos, presença de metástases linfonodais e hepáticas e estadiamento TNM da neoplasia. O estudo estatístico foi realizado com os testes de Mann-Whitney, Kruskal-Wallis e exato de Fisher. resultados: A expressão do marcador CD10 foi maior no tecido do carcinoma colorretal do que na mucosa não neoplásica adjacente (p<0,0001) e foi maior nas lesões exofíticas (p=0,04). A expressão da proteína CD10 não apresentou relação com os demais aspetos clínicos e patológicos da neoplasia colorretal. Conclusões: A expressão da proteína CD10 foi mais intensa no tecido neoplásico do carcinoma colorretal do que na mucosa não neoplásica adjacente e relacionou-se com o aspecto exofítico do tumor. Palavras

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CD10

Riemann¹

2002

Wiley Encyclopedia of Molecular Medicine

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Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon

Cited by 83 publications

References 24 publications

CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression

CD10 protein expression in tumor and stromal cells of malignant melanoma is associated with tumor progression

Tissue expression of CD10 protein in colorectal carcinoma: correlation with the anatomopathological features of the tumor and with lymph node and liver metastases

CD10

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