Expression of CD147 in endometriosis

Li, Y.; Wang, L.; Tian, Fang; Xiao, Fengjun; Xu, Dan; Zhao, Yuming

doi:10.1016/s0015-0282(01)03147-8

Cited by 2 publications

(3 citation statements)

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“…This disorder is characterised by extrauterine proliferation of endometrial tissue, and though the causes remain unclear numerous inflammatory mediators and pathways show altered expression patterns. Proteomics studies reveal ANXA1 overexpression in glandular epithelia of eutopic endometrium from endometriosis patients versus healthy controls (Li et al 2008), and further in ectopic versus eutopic endometriosis samples (Meola et al 2010). Full-length ANXA1 protein was also detected in peritoneal fluid samples from endometriosis patients, while the receptor FPR2 was also up-regulated in ectopic endometriosis samples (Motohashi et al 2005).…”

Section: Menstrual Functionmentioning

confidence: 99%

“…Levels are notably high in reproductive tissues with levels in adult rabbit ovary and pregnant uterus higher than in immature and non-pregnant animals respectively (Tsao et al 1995). ANXA1 is strongly expressed in human endometrial glandular epithelia as well as isolated stromal cells (Li et al 2008). Expression is also observed in term amnionic epithelia and chorionic trophoblast with high levels evident in placental syncytiotrophoblast and placental tissue (Romisch et al 1992, Sun et al 1996.…”

Section: Glucocorticoids and Anxa1mentioning

confidence: 99%

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Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

Hutchinson

Rajagopal²,

Sales³

et al. 2011

Reproduction

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Inflammatory processes are central to reproductive events including ovulation, menstruation, implantation and labour, while inflammatory dysregulation is a feature of numerous reproductive pathologies. In recent years, there has been much research into the endogenous mechanisms by which inflammatory reactions are terminated and tissue homoeostasis is restored, a process termed resolution. The identification and characterisation of naturally occurring pro-resolution mediators including lipoxins and annexin A1 has prompted a shift in the field of anti-inflammation whereby resolution is now observed as an active process, triggered as part of a normal inflammatory response. This review will address the process of resolution, discuss available evidence for expression of pro-resolution factors in the reproductive tract and explore possible roles for resolution in physiological reproductive processes and associated pathologies. Reproduction (2011) 142 15-28

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Section: Menstrual Functionmentioning

confidence: 99%

Section: Glucocorticoids and Anxa1mentioning

confidence: 99%

Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

Hutchinson

Rajagopal²,

Sales³

et al. 2011

Reproduction

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“…As well as affecting the metabolism of arachidonic acid, ANXA1 inhibits the activity of other pro-inflammatory enzymes (nitric-oxide synthase in macrophages and cyclooxygenases in activated microglia) and has an inhibitory effect on both neutrophil and monocyte migration in inflammation (Parente and Solito 2004;Hutchinson et al 2011). Expression of ANXA1 is widespread, including high levels in macrophages and PMN (Perretti and D'Acquisto 2009) and human endometrial glandular epithelial and stromal cells (Li et al 2008). ANXA2 is a suppressor of cytosolic PLA2 and has been reported as being upregulated in the receptive human endometrium (Domínguez et al 2009).…”

Section: Discussionmentioning

confidence: 99%

Influence of pathogenic bacteria species present in the postpartum bovine uterus on proteome profiles

Ledgard

Smolenski

et al. 2015

Reprod. Fertil. Dev.

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Abstract. In the first 2-3 weeks after parturition .90% of dairy cows will have some form of uterine infection. Uterine contamination with pathogens, such as Trueperella (formerly Arcanobacterium) pyogenes increases the risk of developing more severe endometritis, which can reduce conception rates. In this study, we compared the uterine proteome of cows infected with Trueperella pyogenes with that of uninfected cows, using 2D gel electrophoresis, and identified annexins A1 and A2 (ANXA1 and ANXA2), apolipoprotein A-1, calprotectin (S100A9), cathelicidin, enolase 1 (ENO1), peptidoglycan recognition protein 1 (PGLYRP1), phosphoglycerate mutase 1 (PGAM1), serine dehydratase (SDS) and serine protease inhibitors (SERPIN) B1, B3 and B4 proteins as differing in abundance in endometritis. Subsequently, levels of ten of these proteins were monitored in uterine samples collected from a herd of lactating, dairy cows at 15 and 42 days postpartum (DPP). The levels were compared with the cytology scores of the samples and the bacterial species isolated from the uterus. Cathelicidin, PGLYRP1, SERPINB1 and S100A9 levels at 15DPP showed strong positive correlations (r ¼ 0.78, 0.80, 0.79, and 0.68 respectively; P , 0.001) with % of polymorphonuclear neutrophils (PMN). When compared with other bacterial pathogens identified, Streptococcus agalactiae and Truperella pyogenes induced increased expression of the indicator proteins, suggesting that these organisms may adversely affect the subsequent ability of the cow to conceive. Interestingly, there was no difference in the proportion of cows pregnant at 6 and 17 weeks after start of mating between the cows with high or low %PMN.

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Expression of CD147 in endometriosis

Cited by 2 publications

References 0 publications

Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

Molecular regulators of resolution of inflammation: potential therapeutic targets in the reproductive system

Influence of pathogenic bacteria species present in the postpartum bovine uterus on proteome profiles

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