Expression of CD1a by Langerhan’s Cells in Oral Lichen Planus - A Retrospective Analysis

Kulkarni, Ganesh; Sakki, Esther Priyadarshini; Kumar, Yennavaram Vijay; Kolimi, Sadananda; Perika, Ravi; Karthik, Kalepu Venkata; Kumar, Kandukuri Mahesh; Kalyan, V Siva

doi:10.7860/jcdr/2016/19189.7966

Cited by 9 publications

(14 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This difference between CD1a and langerin has been observed in OLP, where langerin DCs were mainly located along the LP interface and dermal CD1a DCs were less frequent in this location 23,24 . In our study, CD1a and langerin coincide with the LE inflammatory infiltrate locations, suggesting its role in OLE pathogenesis.…”

Section: Discussionsupporting

confidence: 73%

“…This difference between CD1a and langerin has been observed in OLP, where langerin DCs were mainly located along the LP interface and dermal CD1a DCs were less frequent in this location. 23,24 According to the literature, increased CD123 has been found in cutaneous LE and it helps differential diagnoses. 25 The only study evaluating pDCs in OLE lesions to date found increased CD123 in the LP.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells

Marques,

Hsieh,

Lourenço

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

BackgroundDendritic cells participate in the pathophysiology of lupus erythematosus (LE), which are studied in systemic and cutaneous forms; however, little is known about their oral manifestations.MethodsThe expressions of dendritic cell markers (including CD1a, CD21, CD123, and langerin) were investigated by immunohistochemistry technique. Sixty intraoral and lower lip LE lesions, and additional 10 control samples were collected from 2003 to 2019. They were topographically analyzed in the epithelium (EP), lamina propria (LP), epithelial junction (JUN), and deep perivascular (PV) areas.ResultsThe expression of CD1a was decreased in the EP (p = 0.003) and increased in the deep PV area (p = 0.002). Langerin immunostaining showed no significant decrease in EP (p = 0.944); however, it increased in LP (p = 0.012) and JUN (p = 0.006). CD21 was expressed in only two specimens (EP, p = 0.012; LP, p < 0.001; deep PV area, p = 0.018). CD123 expression increased in all topographies (EP, p < 0.005; LP, p < 0.001, JUN, p < 0.001; deep PV, p < 0.001). The comparison between vermilion and intraoral mucosa LE lesions suggested that sun‐exposed sites showed higher expression of CD123 (EP, p = 0.024; LP, p = 0.047; JUN, p = 0.001).ConclusionsCD1a, langerin, and CD123 expressions were detected coincidently surrounding the inflammatory infiltrate in oral LE, suggesting that these cells may play an important role in immune response. Interestingly, plasmacytoid dendritic cells showed increased CD123 expression in sun‐exposed site lesions, which point out a possible function in their pathogenesis. Further studies are needed to confirm this hypothesis.

show abstract

Section: Discussionsupporting

confidence: 73%

“…This difference between CD1a and langerin has been observed in OLP, where langerin DCs were mainly located along the LP interface and dermal CD1a DCs were less frequent in this location. 23,24 According to the literature, increased CD123 has been found in cutaneous LE and it helps differential diagnoses. 25 The only study evaluating pDCs in OLE lesions to date found increased CD123 in the LP.…”

Section: Discussionmentioning

confidence: 99%

Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells

Marques,

Hsieh,

Lourenço

et al. 2024

J Cutan Pathol

View full text Add to dashboard Cite

show abstract

“…Dendritic LCs have been attributed an important role in the initiation of the inflammatory process in OLP, possibly related to their capture and presentation of antigens to T cells [ 28 ]. It has been suggested that the increased number of LCs in the epithelium of OLP lesions is due to the capture of an unidentified antigen, leading to the mobilization of numerous LCs to the site, which in turn prevents, to some extent, the destruction of the epithelium in OLP [ 29 ]. The presence of CD1a + LCs in the connective tissue may be explained by the fact that after antigen capture, the activated LCs, in an intermediate stage of maturation, migrate to the regional lymph nodes and present captured antigens to T cells [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia

Dafar

Siarov

Mostaghimi

et al. 2022

International Journal of Dentistry

View full text Add to dashboard Cite

Although oral lichen planus (OLP) and oral leukoplakia (LPL) have different pathogenetic profiles, both may involve chronic inflammation. The aim of this observational study was to evaluate the inflammatory cell profiles of OLP and LPL. The inflammatory cell infiltrates in patients with OLP and LPL were analyzed for the presence of Langerhans cells (LCs; CD1a), T cells (CD3), and B cells (CD20), as well as for the proliferation marker Ki-67. Biopsied specimens from patients with OLP (N = 14) and LPL without dysplasia (N = 13) were immunohistochemically stained with antibodies directed against CD1a, CD3, CD20, and Ki-67, followed by quantitative analyses. A significant increase in the number of CD3+ cells and CD20+ cells was found in the submucosa of OLP, as compared to LPL ( p < 0.01 ). Likewise, the number of CD3+ cells was significantly higher in the epithelium of OLP than of LPL ( p < 0.05 ). No differences were found in the expression of Ki-67 and the number of CD1a+ cells between the two groups. Although an immune response is elicited in both conditions, there are differences at the cellular level between OLP and LPL. A more robust immune activation involving T cells and B cells is seen in OLP. The role of B cells in OLP needs to be further elucidated. Although the number of B cells in LPL is low, their role in the inflammatory response cannot be ruled out.

show abstract

“…The authors described an increase in the number of FoxP3 + cells in the erosive form of the disease and correlated these additional cells with the microbiota alteration present in the patients, particularly in people suffering from erosive OLP. Epithelial Langerhans cells also play an active role in the disease, since they are involved in antigen detection and capture, as well as subsequent presentation to T cells (Kulkarni et al 2016 ).…”

Section: On the Diseasementioning

confidence: 99%

Oral lichen planus: a microbiologist point of view

2021

View full text Add to dashboard Cite

Oral lichen planus (OLP) is a chronic disease of uncertain etiology, although it is generally considered as an immune-mediated disease that affects the mucous membranes and even the skin and nails. Over the years, this disease was attributed to a variety of causes, including different types of microorganisms. This review analyzes the present state of the art of the disease, from a microbiological point of view, while considering whether or not the possibility of a microbial origin for the disease can be supported. From the evidence presented here, OLP should be considered an immunological disease, as it was initially proposed, as opposed to an illness of microbiological origin. The different microorganisms so far described as putative disease-causing agents do not fulfill Koch’s postulates; they are, actually, not the cause, but a result of the disease that provides the right circumstances for microbial colonization. This means that, at this stage, and unless new data becomes available, no microorganism can be envisaged as the causative agent of lichen planus.

show abstract

Expression of CD1a by Langerhan’s Cells in Oral Lichen Planus - A Retrospective Analysis

Cited by 9 publications

References 26 publications

Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells

Oral lupus erythematosus: Immunohistochemical evaluation of CD1a, CD21, CD123, and langerin expression in dendritic cells

Langerhans Cells, T Cells, and B Cells in Oral Lichen Planus and Oral Leukoplakia

Oral lichen planus: a microbiologist point of view

Contact Info

Product

Resources

About