Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells

Nakiri, Yutaka; Minowa, Kentaro; Suzuki, Jun; Mitsuo, Akiko; Amano, Hirofumi; Morimoto, Shinji; Tokano, Yoshiaki; Takasaki, Yoshinari

doi:10.1007/s10067-007-0665-3

Cited by 10 publications

(6 citation statements)

References 13 publications

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“…Furthermore, it is known that elderly produce increased levels of antibodies to autologous antigens often accompanied by autoimmune phenomena (Candore et al, , 1997Banerjee et al, 2002) and are less able to make high-affinity antibodies to foreign antigens. Indeed, increased CD5 + B lymphocytes, that, as known, play a key role as producers of autoantibodies (Dalloul, 2009;Youinou et al, 1988), have been demonstrated in old humans (Weksler, 2000) and mice (Alter-Wolf et al, 2009b), in lupus mouse models (Zhong et al, 2009) and in human rheumatoid arthritis (Nakiri et al, 2007). However in our previous paper (Colonna Romano et al, 2003) we found an age-related decrease of CD5 + B cells, The intriguing aspect is that, in our elderly population, there is an increase of the IgD − CD27 − DN B cells, and one hypothesis might be that these cells could be responsible for production of autoantibodies or cytokines that lead to an imbalance of the mechanism controlling the immune response against self antigens.…”

Section: Discussionmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

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a b s t r a c tImmunosenescence contributes to the decreased ability of the elderly to control infectious diseases, which is also reflected in their generally poor response to new antigens and vaccination. It is known that the T cell branch of the immune system is impaired in the elderly mainly due to expansion of memory/effector cells that renders the immune system less able to respond to new antigens. B lymphocytes are also impaired in the elderly in terms of their response to new antigens. In this paper we review recent work on B cell immunosenescence focusing our attention on memory B cells and a subset of memory B cells (namely IgG + IgD − CD27 − ) that we have demonstrated is increased in healthy elderly.

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Section: Discussionmentioning

confidence: 99%

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Bulati¹,

Buffa²,

Candore³

et al. 2011

Ageing Research Reviews

101

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“…They do not delete B1 Bcells and, n the presence of alarm signals, autoantigens may even efficiently stimulate them. In contrast to the B1a B-cell population (that shows a constitutive low activity), CD5 (-) B1b B-cells (implicated in the synthesis of TI2 antigen-specific antibodies) were shown to be capable of significant increases in their activity [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis

et al. 2008

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Introduction Although natural autoantibodies make up the majority of circulating immunoglobulins and are also present in high numbers in therapeutically used intravenous immunoglobulin preparations, they have received little attention and their precise role remains largely unknown. An increasing awareness of the importance of posttranslational autoantigen modifications and glycobiology led us to explore carbohydratereactive natural autoantibodies in patients with rheumatoid arthritis. This study examined systematic antibodies reactive to glycosaminoglycans (GAGs), the carbohydrate components of proteoglycans that are released in large amounts from degrading cartilage.

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“…B-CLL, the most frequent CD5-positive mature B-cell malignancy, is often complicated with autoimmune diseases, and some autoimmune diseases, such as rheumatoid arthritis or systemic lupus erythematosus, show an altered function of CD5-positive B-cells [15,16]. We previously reported a similar CD5 -positive DLBCL that developed in a patient with autoimmune hemolytic anemia [17].…”

Section: Discussionmentioning

confidence: 94%

Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation

et al. 2008

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We report a unique, aggressive B-cell lymphoma that developed after the long-term remission of follicular lymphoma (FL). FL cells were negative for CD5, whereas aggressive lymphoma cells were positive for CD5. In FL, one immunoglobulin heavy chain gene (IGH) allele underwent V/D/J recombination and another t(14;18)(q32;q21). In aggressive lymphoma, one IGH allele underwent D/J recombination and another translocation, but not t(14;18)(q32;q21). An aggressive lymphoma-specific D/J sequence was detected in FL tissue. Our results indicated that the two tumors arose from distinct B cells and that they existed concurrently in the same lymph node.

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Expression of CD22 on peripheral B cells in patients with rheumatoid arthritis: relation to CD5-positive B cells

Cited by 10 publications

References 13 publications

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

B cells and immunosenescence: A focus on IgG+IgD−CD27− (DN) B cells in aged humans

Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis

Aggressive CD5-positive B-cell lymphoma after remission of CD5-negative follicular lymphoma with distinct immunoglobulin heavy chain rearrangement and translocation

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