Expression of CD28 and cytotoxic T lymphocyte antigen 4 at the maternal-fetal interface in women with unexplained pregnancy loss

Wang, Xipeng; Ma, Zhiwei; Hong, Yan; Lu, Peihua; Lin, Qi

doi:10.1016/j.ijgo.2006.01.027

Cited by 24 publications

(14 citation statements)

References 23 publications

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“…8,9 Additionally, a decreased ratio of CTLA-4(+)/CD28(+) expression, both in peripheral blood and in deciduas, seems to be associated with pregnancy loss. 28 Several studies have shown that ICOS has a pivotal role in T-cell activation and in Th1/Th2 differentiation. 29 Despite this, the role of ICOS has not been previously investigated in pregnancy, a condition that is clearly influenced by these processes.…”

Section: Discussionmentioning

confidence: 99%

Immunoregulatory gene polymorphisms in women with preeclampsia

et al. 2010

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The costimulatory molecules CD28, cytotoxic T-lymphocyte antigen-4 (CTLA-4) (cytotoxic T-lymphocyte-associated antigen-4) and inducible costimulator (ICOS) are believed to have a critical modulatory role in the immune response. However, few studies have been performed on the role of these immune regulatory molecules and their polymorphisms in women with preeclampsia (PE). The aim of our study was to evaluate the CTLA4 (+49 A/G) (rs 231775), CD28 (+17 T/C) (rs 3116496) and ICOS (À1564 T/C) (rs 4675378) gene polymorphisms in Brazilian women with PE. This case-control study included 130 patients with PE and 261 control women without any obstetric or systemic disorders. Genomic DNA was extracted from peripheral blood, and the polymorphism genotyping was performed by digesting the PCR products with the restriction endonucleases BbvI (CTLA-4), AfeI (CD28) and AluI (ICOS). Data were analyzed by v 2 or Fisher's exact test; a P-value of o0.05 was considered as significant. There were significant differences in the ICOS genotype and allelic frequencies between the PE and control groups (P¼0.01 and P¼0.01, respectively). We found a significantly lower frequency of the ICOS (À1564) T allele in women with mild PE compared with the controls. There were no differences in the CTLA-4 (+49 A/G) and CD28 (+17 T/C) genotypes and allelic frequencies between the PE patients and controls. Our data suggest that PE is associated with ICOS, but is not associated with the CTLA-4 or CD28 gene polymorphisms.

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Section: Discussionmentioning

confidence: 99%

Immunoregulatory gene polymorphisms in women with preeclampsia

et al. 2010

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“…Polymorphism in the CTLA4 gene has recently been suggested to confer susceptibility to recurrent spontaneous abortion in Chinese women (85).…”

Section: B7 Family Of Costimulatory Moleculesmentioning

confidence: 99%

Maternal Acceptance of the Fetus: True Human Tolerance

Guleria

Sayegh

2007

The Journal of Immunology

207

191

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Induction and maintenance of immunologic tolerance in humans remains a desirable but elusive goal. Therefore, understanding the physiologic mechanisms of regulation of immune responses is highly clinically relevant for immune-mediated diseases (e.g., autoimmunity and asthma/allergy) and for cell and organ transplantation. Acceptance of the fetus, which expresses paternally inherited alloantigens, by the mother during pregnancy is a unique example of how the immune system reshapes a destructive alloimmune response to a state of tolerance. Understanding the complex mechanisms of fetomaternal tolerance has important implications for developing novel strategies to induce immunologic tolerance in humans in general and for prevention of spontaneous abortion in at-risk populations in particular.

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“…Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a negative regulator of T cell activation [2] expressed in placental fibroblasts and may modulate peripheral self-tolerance of the allogenic fetus [3,4]. It is a stimulatory molecule involved in T-cell activation at the maternal–fetal interface in women with unexplained pregnancy loss [5,6]. In this study, we investigate the possible associations of Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with idiopathic recurrent pregnancy loss (RPL).…”

Section: Introductionmentioning

confidence: 99%