Expression of Cd31 Proteins, Willebrand Factor at Different Times of Covid-19 Pneumonia

Abstract

The role of the SARS-CoV-2 coronavirus in the genesis of pulmonary vascular lesions in COVID-19 pneumonia is discussed. There are few pathoanatomical works devoted to the study of the expression of CD31 proteins, von Willebrand factor involved in maintaining hemostasiological balance at different times of COVID-19 pneumonia. Materials and methods. The study of autopsy lung material of 80 deceased with COVID-19 pneumonia, taking into account the chronological timing of the development of the disease (up to 14 days, 15-21 days, 22-40 days). A complex of morphological, histological, immunohistochemical studies (CD31, vWF) was performed with computer morphometry and statistical processing of the results. Results. Pronounced vascular changes with the development of microthrombus formation are observed at 2-3 weeks of the disease, which is accompanied by a bright expression of the CD31 protein, a moderate expression of the von Willebrand factor protein. After 22-40 days of development of COVID-19 pneumonia, there are signs of neoangiogenesis, remodeling of pulmonary vessels. © Тодоров C.C., Тодоров C.C. (мл.), Казьмин А.С., 2022 Conclusions. The data obtained supplement our understanding of the pathogenesis of COVID-19 pneumonia at different stages of development, the role of the expression of CD31 and vWF proteins in pulmonary vessels, which are important for assessing endothelial dysfunction and hemostasis.