Expression of CD44v6 has no Prognostic Value in Patients with Colorectal Cancer

Abstract

Changes in CD446 expression level do not predict tumour spread or patient survival in colorectal cancer.

Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis

“…However, the prognostic relevance of CD44v6 in colorectal cancer has been considered controversial. Several studies have shown that overexpression of CD44v6 indicates poor prognosis [8,9,10,11], whereas other studies could not confirm those findings [5,12,13,14,15]. Our hypothesis is that these discrepancies are related to the fact that the function of CD44v6 depends on the HA content of the cell-surrounding matrix.…”

Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer

“…In some immunohistochemical studies, high intratumoral CD44v6 levels were appreciably associated with a shorter overall patient survival (Mulder et al 1994;Ropponen et al 1998;Wielenga et al 1998). However, other authors, also using immunohistochemical methods, have not found any significant association between the expression of CD44v6 and prognosis (Gotley et al 1996;Jungling et al 2002;Morrin and Delaney 2002). These discordant results may be due to different methodological aspects related to the staining techniques (Gilcrease et al 1999).…”

“…In these studies, antibodies recognizing different CD44v isoforms, i.e., CD44v3 (Kuniyasu et al 2001;Ropponen et al 1998;Wielenga et al 2000b), CD44v6 (Mulder et al 1994;Ropponen et al 1998;Wielenga et al 1998), andCD44v8-10 (Yamaguchi et al 1996), all gave similar results. Nevertheless, also using immunohistochemical assays (Coppola et al 1998;Gotley et al 1996;Koretz et al 1995), reverse transcriptase-polymerase chain reaction, or Southern blotting methods (Jungling et al 2002;Morrin and Delaney 2002), no correlation has been found between CD44v6 expression and prognosis. In addition, it has been suggested that distant metastases show downregulation of the CD44v6 expression in comparison with primary tumors (Finke et al 1995;Nanashima et al 2001).…”

The pattern of CD44 and matrix metalloproteinase 9 expression is a useful predictor of ulcerative colitis–associated dysplasia and neoplasia

“…There are clear discrepancies in the interpretation of the expression of CD44 in relation to different lesions in the intestinal mucosa in most of studies [41,42] with evidence that seems to indicate that a low expression of CD44 correlates with a greater capacity for metastasis and recurrence, whereas other studies reported a correlation between high expression of CD44 and poor prognosis [43,44]. This may be in part due to presence of multiple splicing CD44 variants, lack of full understanding of how variant expression is regulated under different conditions and how the CD44 variants modulate cellular behavior, and lack of detecting the cleavage CD44.…”