Expression of CD45, CD34, CD10, and human leukocyte antigen-DR in acute lymphoblastic leukemia

Jaafar, Faris H; Kadhom, Areej Emad

doi:10.4103/ijh.ijh_31_17

Cited by 5 publications

(1 citation statement)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…42 Also, our finding agrees with two studies in Brazil by De Sousa et al, and in Iraq, by Jaafar and Kadhom both found that total white blood cell count is significantly increased in T-ALL than B-ALL. 43,44 In this study, the genotyping of MTRR (A66G) polymorphism showed that the homozygous genotypes AA and GG were more frequent in the patients compared to the control group. The heterozygous genotype AG was lower in the patients compared to the control group.…”

Section: Discussionmentioning

confidence: 58%

Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Edris,

Merghani,

Gafar

et al. 2023

Ital J Med

View full text Add to dashboard Cite

Background and Objectives. The enzyme methionine synthase reductase is involved in cellular methylation reactions, DNA synthesis, and epigenetic processes. It is encoded by the MTRR gene, which garnered a lot of attention in current medical genetics research. This study was conducted to study the association between MTRR (A66G) polymorphism and the risk of developing acute lymphoblastic leukemia among Sudanese patients. Materials and Methods. This is a case-control study in which 150 patients with acute lymphoblastic leukemia (ALL) and 150 healthy participants as a control group were enrolled. DNA was extracted and analyzed for the MTRR (A66G) polymorphism using the real-time polymerase chain reaction. Results. Based on flow cytometry results, B-ALL was more common (79%) than T-ALL (21%). The comparison of hematological parameters in acute lymphoblastic leukemia subtypes showed a statistically significant high mean total white blood count (P=0.000) and mean blast percentage (P=0.050) in patients with T-ALL. The molecular analysis showed that the incidence of the MTRR homozygous genotypes AA and GG were higher in the patients (44% and 9.3%, respectively) compared to the control group (40% and 6.7%, respectively). In comparison, the heterozygous genotype AG was lower in the patients (46.7%) than in the control group (53.3%). However, the association between the polymorphism and acute lymphoblastic leukemia risk was not statistically significant (OR: 1.179, 95% CI 0.7459-1.865, P=0.445). Conclusions. This study concluded that MTRR A66G polymorphism was not associated with the risk of acute lymphoblastic leukemia among the Sudanese population.

show abstract

Section: Discussionmentioning

confidence: 58%

Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Edris,

Merghani,

Gafar

et al. 2023

Ital J Med

View full text Add to dashboard Cite

show abstract

Immunophenotypic properties association of CLL and ALL patient cells by flow cytometry analysis

Rasul,

Wsoo,

Hassan

et al. 2024

Journal of Taibah University Medical Sciences

View full text Add to dashboard Cite

CD34 is not Expressed by Blasts in a Third of B-ALL Patients and its Negativity is associated with Aberrant Marker Expression: A Retrospective Analysis

Garg

Gupta

Kotru

2021

Asian Pac J Cancer Prev

View full text Add to dashboard Cite

Background: CD34 antigen is expressed by early hematopoietic progenitor cells and acute leukemia cells. Its expression is associated with good prognosis in acute myeloid leukemia. Literature is sparse on its prognostic significance in B-acute lymphoblastic leukemia (B-ALL) especially from India. Hence the present study was undertaken to analyse the frequency of CD34 expression in B-ALL in Indian patients and determine its prognostic significance by associating with other prognostic markers and aberrant antigen expression. Methods: Seventy-five B-ALL patients diagnosed by flow cytometry over a period of 3½ year were studied. Correlation of CD34 expression was studied with gender, age, total leucocyte count (TLC), French-American-British (FAB) morphological type, immuno-phenotypic markers, cytogenetics and minimal residual disease. Differences between groups were evaluated using Student's T-test for quantitative data and Chi-square test/Fishers exact T-test for qualitative variables. P value <0.05 was considered significant. Results: CD34 was positive in 66.66% (50/75) cases while it was negative in rest (33.33%; 25/75) cases. CD13, CD33, CD5, CD7 and CD11b were more frequently expressed in CD34 negative B-ALL (p=0.025). No association of CD34 expression was found with gender, age, TLC, FAB morphological type, other immune-phenotypic markers, MRD and cytogenetics studied. Conclusions: The expression of CD34 does not associate with known prognostic markers in B-ALL. However, absence of CD34 is associated with aberrant immunophenotypic expression (myeloid + T-cell antigens) in these patients. Larger studies with larger sample size and more extensive immunophenotypic panel needs to be done in Indian setup to confirm these findings.

show abstract

Expression of CD45, CD34, CD10, and human leukocyte antigen-DR in acute lymphoblastic leukemia

Cited by 5 publications

References 4 publications

Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Association of methionine synthase reductase (MTRR A66G) polymorphism with susceptibility to acute lymphoblastic leukemia

Immunophenotypic properties association of CLL and ALL patient cells by flow cytometry analysis

CD34 is not Expressed by Blasts in a Third of B-ALL Patients and its Negativity is associated with Aberrant Marker Expression: A Retrospective Analysis

Contact Info

Product

Resources

About