1994
DOI: 10.1002/1097-0142(19940215)73:4<1257::aid-cncr2820730421>3.0.co;2-l
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Expression of cell adhesion molecules associated with germinal center in Hodgkin's disease: An immunohistochemical study. The germinal center related complex and histologic subtypes

Abstract: Background. Of the four elements known to be associated with germinal center formation—B‐cells, follicular dendritic cells, T‐cells, and the cell adhesion molecules—the first three have been well studied in Hodgkin's disease, especially the nodular lymphocytic predominance subtype, established as a tumor of germinal center origin. However, no study has been done on the expression of the cell adhesion molecules associated with germinal center formation in Hodgkin's disease. Methods. Using the avidin‐biodin pero… Show more

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Cited by 6 publications
(4 citation statements)
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“…Our results confirmed earlier reports ( Sandvej et al , 1993 ; Ree et al , 1994 ; Ruco et al , 1992 ) showing that ICAM‐1 was expressed by HRS cells in evaluable cases. The vascular endothelium stained positive for ICAM‐1 to a variable degree in all biopsies and for VCAM‐1 in 10/12 evaluable biopsies.…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…Our results confirmed earlier reports ( Sandvej et al , 1993 ; Ree et al , 1994 ; Ruco et al , 1992 ) showing that ICAM‐1 was expressed by HRS cells in evaluable cases. The vascular endothelium stained positive for ICAM‐1 to a variable degree in all biopsies and for VCAM‐1 in 10/12 evaluable biopsies.…”
Section: Discussionsupporting
confidence: 92%
“…ICAM‐1 is overexpressed not only by HRS‐cells but also by vascular endothelium, FDCs and infiltrating macrophages ( Mosmann & Sad, 1996; Sandvej et al , 1993 ). VCAM‐1 expression in HD lymph nodes has been limited to some parts of the vascular endothelium and FDCs ( Ree et al , 1994 ; Ruco et al , 1992 ). Serum levels of soluble ICAM‐1 (sICAM‐1) are elevated in HD ( Banks et al , 1993 ), and correlate with stage, disease activity and survival ( Pizzolo et al , 1993 ; Christiansen et al , 1995 ).…”
mentioning
confidence: 99%
“…In Hodgkin's disease, follicular dendritic cell networks are well preserved and even expanded in nodular lymphocyte predominance type 12,14,40 , while in mixed cellularity and lymphocyte depletion, they are widely broken up 12,14 . In nodular sclerosing Hodgkin's disease, follicular dendritic cell foci are prominently displayed in the centre of the nodules, suggesting an association between nodular sclerosis and germinal centre formation 41 .…”
mentioning
confidence: 99%
“…Actually, in Hodgkin's disease, aggregates of follicular dendritic cells, B-cells, and Reed-Sternberg cells and variants form 'germinal centre-related complexes'. These cells were shown to express cell adhesion molecules normally found in the germinal centres 41 .…”
mentioning
confidence: 99%