Expression of chemokine receptor CXCR4 during chick embryo development

Yusuf, Faisal; Rehimi, Rizwan; Dai, Fangping; Brand‐Saberi, Beate

doi:10.1007/s00429-005-0013-9

Cited by 46 publications

(47 citation statements)

References 33 publications

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“…2 I). These expression patterns are summarized in Figure 2C and are supported by other recent in situ hybridization analyses in chick (Yusuf et al, 2005) showing strong expression of CXCR4 in developing SGs but absence of expression in immature DRGs. Based on these data, we hypothesized SDF-1 expression may guide SG precursors toward the dorsal aorta.…”

Section: Cxcr4 Is Expressed By a Subset Of Trunk Nccssupporting

confidence: 86%

CXCR4 Controls Ventral Migration of Sympathetic Precursor Cells

Kasemeier-Kulesa¹,

McLennan²,

Romine³

et al. 2010

J. Neurosci.

109

106

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The molecular mechanisms that sort migrating neural crest cells (NCCs) along a shared pathway into two functionally discrete structures, the dorsal root ganglia and sympathetic ganglia (SGs), are unknown. We report here that this patterning is attributable in part to differential expression of the chemokine receptor, CXCR4. We show that (1) a distinct subset of ventrally migrating NCCs express CXCR4 and this subset is destined to form the neural core of the sympathetic ganglia, and (2) the CXCR4 ligand, SDF-1, is a chemoattractant for NCCs in vivo and is expressed adjacent to the future SGs. Reduction of CXCR4 expression in NCCs disrupts their migration toward the future SGs, whereas overexpression of CXCR4 in non-SG-destined NCCs induces them to migrate aberrantly toward the SGs. These data are the first to demonstrate a major role for chemotaxis in the patterning of NCC migration and demonstrate the neural crest is composed of molecularly heterogeneous cell populations.

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Section: Cxcr4 Is Expressed By a Subset Of Trunk Nccssupporting

confidence: 86%

CXCR4 Controls Ventral Migration of Sympathetic Precursor Cells

Kasemeier-Kulesa¹,

McLennan²,

Romine³

et al. 2010

J. Neurosci.

109

106

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“…We have previously reported the expression pattern of CXCR4 in the developing chick embryo (Yusuf et al, 2005). In our present work, we noticed that complementarity exists between the expression pattern of SDF-1 and CXCR4 during several stages of embryonic development.…”

Section: Discussionsupporting

confidence: 65%

“…In mice, the expression patterns of stromal cell-derived factor-1 and its receptor are also particularly noticeable in the developing cardiac, vascular and craniofacial system during organogenesis (McGrath et al, 1999). CXCR4 receptor is widely expressed in various tissues of the developing chick embryo such as in the ventral forgut portal, developing somites, tailbud, Wolffian duct, the lateral plate mesoderm and developing blood vessels (Yusuf et al, 2005). In our study we documented the normal expression pattern of CXCL12 (SDF-1) in chick embryos and we observed that SDF-1 is widely expressed in most of the embryonic tissues during development such as in the ectoderm, the sclerotome, the intersomitic spaces and the mesenchyme of the developing limbs.…”

Section: B C D Ementioning

confidence: 99%

Stromal-derived factor-1 (SDF-1) expression during early chick development

Rehimi¹,

Khalida²,

Yusuf³

et al. 2008

Int. J. Dev. Biol.

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Cell migration plays a fundamental role in a wide variety of biological processes including development, tissue repair and disease. These processes depend on directed cell migration along and through cell layers. Chemokines are small secretory proteins that exert their effects by activating a family of G-protein coupled receptors and have been shown to play numerous fundamental roles in the control of physiological and pathological processes during development and in adult tissues, respectively. Stromal-derived factor-1 (SDF-1/CXCL12), a ligand of the chemokine receptor, CXCR4, is involved in providing cells with directional cues as well as in controlling their proliferation and differentiation. Here we studied the expression pattern of SDF-1 in the developing chick embryo. We could detect a specific expression of SDF-1 in the ectoderm, the sclerotome, the intersomitic spaces and the developing limbs. The expression domains of SDF-1 reflect its role in somitic precursor migration and vessel formation in the limbs.

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“…Seen in this light the extensive role for chemokine signaling in the control of leukocyte trafficking can be thought of as an evolutionary development of this original function. Consistent with this idea, it has been demonstrated that of all chemokines and chemokine receptors, SDF-1 and CXCR4 are the most widely expressed during the development of the embryo (Knaut et al, 2005;Knaut et al, 2003;McGrath et al, 1999;Moepps et al, 2000;Rehimi et al, 2008;Tissir et al, 2004;Yusuf et al, 2005). Moreover, the expression patterns for both SDF-1 and CXCR4 are highly dynamic consistent with the possibility that they have shifting developmental roles in the formation of many different tissues.…”

Section: The Chemokine Familymentioning

confidence: 56%

CXCR4 signaling in the regulation of stem cell migration and development

Miller¹,

Banisadr²,

Bhattacharyya³

2008

Journal of Neuroimmunology

160

125

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The regulated migration of stem cells is a feature of the development of all tissues and also of a number of pathologies. In the former situation the migration of stem cells over large distances is required for the correct formation of the embryo. In addition, stem cells are deposited in niche like regions in adult tissues where they can be called upon for tissue regeneration and repair. The migration of cancer stem cells is a feature of the metastatic nature of this disease. In this article we discuss observations that have demonstrated the important role of chemokine signaling in the regulation of stem cell migration in both normal and pathological situations. It has been demonstrated that the chemokine receptor CXCR4 is expressed in numerous types of embryonic and adult stem cells and the chemokine SDF-1/CXCL12 has chemoattractant effects on these cells. Animals in which SDF-1/CXCR4 signaling has been interrupted exhibit numerous phenotypes that can be explained as resulting from inhibition of SDF-1 mediated chemoattraction of stem cells. Hence, CXCR4 signaling is a key element in understanding the functions of stem cells in normal development and in diverse pathological situations.

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Expression of chemokine receptor CXCR4 during chick embryo development

Cited by 46 publications

References 33 publications

CXCR4 Controls Ventral Migration of Sympathetic Precursor Cells

CXCR4 Controls Ventral Migration of Sympathetic Precursor Cells

Stromal-derived factor-1 (SDF-1) expression during early chick development

CXCR4 signaling in the regulation of stem cell migration and development

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