Expression of Chromogranin A in the Mouse Dental Pulp and Periodontal Tissues

Abstract

We examined immunohistochemical expression of Chromogranin A (CgA) in the mouse dental pulp and the periodontal tissues, which exposed to 3 hours immediate teeth separation. In the experimental group, CgA positive staining products were frequently detected in the periodontal fibroblasts and endothelial cells, and also detected in the dental pulp cells. The positive reactions were stronger than that of control specimens. The data suggests that induced expression was due to the mechanical stress of wedge insertion.

HSP70 Expression in the Mouse Dental Pulp after Immediate Teeth Separation

“…In general, the pathological changes of the dental pulp tissue occur due to such things as aging, dental caries, occlusal stimuli, traumatic force and orthodontic mechanical stress. [8][9][10] . Pathological mechanical stress according to the immediate tooth separation using wedge insertion at the endodontic treatment can cause pathological changes in the periodontal tissues.…”