Expression of Clusterin in Human Pancreatic Cancer

Abstract

These results suggest that clusterin expression is induced in pancreatic cancer as well as chronic pancreatitis and that downregulation of clusterin may be involved in the progression of pancreatic cancer.

Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer

“…37 CLU expression was induced in pancreatic cancer and its downregulation may be associated with disease progression. 42 It is not clear, however, in these studies if sCLU versus nCLU expression levels were clearly separable. There is a need for improved methods to detect nCLU in cases like this.…”

“…8,38 In fact, not many studies showed a decrease in sCLU in tumours like that of a proapoptotic. A few reports do, however, suggest decreased sCLU levels in specific cancers, including nonmelanoma skin cancer, 40 oesophageal squamous cell carcinoma, 41 neuroblastoma, 22 prostate, 11,37 and pancreatic cancer 42 (Table 1). In one study, CLU expression was analysed during progression of prostate cancer.…”

A survey of clusterin and fascin expression in sarcomas and spindle cell neoplasms: strong clusterin immunostaining is highly specific for follicular dendritic cell tumor

“…This occasionally resulted in increased background staining that should not be falsely interpreted as positivity within the neoplastic cells. Given the expression of clusterin in a wide variety of benign epithelial cells as well as in carcinomas of the breast, colon, pancreas, ovary, bladder and prostate, [11][12][13][14] it is somewhat surprising that we did not observe strong clusterin staining in any of 11 spindle cell carcinomas. Our case selection was somewhat limited in its scope with the majority representing spindle cell squamous carcinomas from various locations.…”

“…10,11 Among nonhematopoietic neoplasms, overexpression of clusterin has been documented in carcinomas of the breast, colon, pancreas and prostate. [11][12][13][14] The initial immunohistochemical studies using antibodies to fascin documented its expression in Reed-Sternberg cells of classical Hodgkin's lymphoma, and suggested that this might be evidence of the dendritic lineage of these cells. 6 While subsequent studies have shown that the neoplastic cells in Hodgkin's lymphoma are actually of B-cell lineage, the emphasis on fascin as a dendritic cell marker has remained.…”

Diagnostic Evaluation of Urinary Angiogenin (ANG) and Clusterin (CLU) as Biomarker for Bladder Cancer

“…Clusterin has a potential oncogenic role in the development and/or progression of several human cancers including prostate cancer [11], breast carcinoma [12], lung [13], and colon [14] as well as urinary bladder cancer [15]. Few reports do, however, suggest decreased clusterin levels in specific cancers, including esophageal squamous cell carcinoma [16], prostate [17], and pancreatic cancer [18].…”