Expression of Cold-Inducible RNA-Binding Protein (CIRP) in Pituitary Adenoma and its Relationships with Tumor Recurrence

Wang, Mingguang; Zhang, Huan; Heng, Xueyuan; Pang, Qi; Sun, Aigang

doi:10.12659/msm.893128

Cited by 16 publications

(12 citation statements)

References 21 publications

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“…Clinically, we showed that patients with higher CIRP expression are more likely to recur than those with rare or no CIRP expression; Moreover, in postoperative recurrent patients, CIRP expression levels in sample from secondary surgery were remarkably higher than that from the initial one, which indicated that CIRP is correlated with recurrence. This result is consistent with the finding reported in a recent study that recurrent pituitary adenoma expressed significantly higher CIRP levels compared to non-recurrent tumors and CIRP expression is correlated with tumor proliferation and invasion [ 21 ]. CIRP, thus, might be a marker for predicting the risk of CD recurrence.…”

Section: Discussionsupporting

confidence: 93%

Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway

et al. 2016

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Cushing's disease is caused by pituitary corticotroph adenoma, and the pathogenesis of it has remained obscure. Here, we showed that cold inducible RNA binding protein (CIRP) was markedly elevated in corticotroph tumors. Forced overexpression of CIRP in murine AtT20 pituitary corticotroph cell line increased corticotroph precursor hormone proopiomelanocortin (POMC) transcription, ACTH secretion and cellular proliferation. In vivo, CIRP overexpression promotes murine corticotroph tumor growth and enhances ACTH production. Mechanistically, we show that CIRP could promote AtT20 cells proliferation by inducing cyclinD1 and decreasing p27 expression via Erk1/2 signaling pathway. Clinically, CIRP overexpression is significantly correlated with Cushing's disease recurrence. CIRP appears to play a critical tumorigenesis function in Cushing's disease and its expression might be a useful biomarker for tumor recurrence.

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Section: Discussionsupporting

confidence: 93%

Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway

et al. 2016

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“…High level of CIRP in human oral squamous cell carcinoma is associated with a short survival rate [ 73 ]. CIRP expression level is also positively associated the invasive ability of pituitary adenoma in human [ 74 ]. An integrated analysis of serum autoantibody expression profiling in patients with breast cancer, found that serum autoantibody targeting CIRP was significantly increased in patients with breast carcinoma and its change can be used as a prognostic biomarker for cancer progression [ 75 ].…”

Section: The Rna-dependent Function Of Cirp: a Cell Autonomous Functimentioning

confidence: 99%

Recent progress in the research of cold-inducible RNA-binding protein

2017

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Cold-inducible RNA-binding protein (CIRP) is a cold-shock protein which can be induced after exposure to a moderate cold-shock in different species ranging from amphibians to humans. Expression of CIRP can also be regulated by hypoxia, UV radiation, glucose deprivation, heat stress and H2O2, suggesting that CIRP is a general stress-response protein. In response to stress, CIRP can migrate from the nucleus to the cytoplasm and regulate mRNA stability through its binding site on the 3′-UTR of its targeted mRNAs. Through the regulation of its targets, CIRP has been implicated in multiple cellular process such as cell proliferation, cell survival, circadian modulation, telomere maintenance and tumor formation and progression. In addition, CIRP can also exert its functions by directly interacting with intracellular signaling proteins. Moreover, CIRP can be secreted out of cells. Extracellular CIRP functions as a damage-associated molecular pattern to promote inflammatory responses and plays an important role in both acute and chronic inflammatory diseases. Here, we summarize novel findings of CIRP investigation and hope to provide insights into the role of CIRP in cell biology and diseases.

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“…In pituitary adenoma, high CIRP expression correlates with proliferating invasive and recurrent tumor, probably via ERK1/2 signaling pathway [ 102 , 139 ]. In oral squamous cell carcinoma, CIRP is co-expressed with TLR4 and is associated with a short survival rate [ 140 ].…”

Section: Regulation and Functions Of Cirpmentioning

confidence: 99%

Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold

Zhu

Bührer

Wellmann

2016

Cell. Mol. Life Sci.

187

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Cold-inducible RNA-binding protein (CIRP) and RNA-binding motif protein 3 (RBM3) are two evolutionarily conserved RNA-binding proteins that are transcriptionally upregulated in response to low temperature. Featuring an RNA-recognition motif (RRM) and an arginine–glycine-rich (RGG) domain, these proteins display many similarities and specific disparities in the regulation of numerous molecular and cellular events. The resistance to serum withdrawal, endoplasmic reticulum stress, or other harsh conditions conferred by RBM3 has led to its reputation as a survival gene. Once CIRP protein is released from cells, it appears to bolster inflammation, contributing to poor prognosis in septic patients. A variety of human tumor specimens have been analyzed for CIRP and RBM3 expression. Surprisingly, RBM3 expression was primarily found to be positively associated with the survival of chemotherapy-treated patients, while CIRP expression was inversely linked to patient survival. In this comprehensive review, we summarize the evolutionary conservation of CIRP and RBM3 across species as well as their molecular interactions, cellular functions, and roles in diverse physiological and pathological processes, including circadian rhythm, inflammation, neural plasticity, stem cell properties, and cancer development.

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Expression of Cold-Inducible RNA-Binding Protein (CIRP) in Pituitary Adenoma and its Relationships with Tumor Recurrence

Cited by 16 publications

References 21 publications

Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway

Cold inducible RNA binding protein upregulation in pituitary corticotroph adenoma induces corticotroph cell proliferation via Erk signaling pathway

Recent progress in the research of cold-inducible RNA-binding protein

Cold-inducible proteins CIRP and RBM3, a unique couple with activities far beyond the cold

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