In this paper, the ecohydrology measures including water management and interaction of ecological hydrology were considered to take a holistic view on the impact of climate, ecology, environment, and topography on different types of disasters. In the first step, the contents of the grim disaster situation and the information framework of ecohydrology with disasters were evaluated. Nest, the creation of ecohydrology and its work with related disasters were summarized. Three disasters including flood, drought, and geohazard were evaluated and three examples (Dujiangyan Irrigation Project, Karez, and Ecological slope) have been separately discussed for considering the concept of the problem. Depending on the characteristics and potential for an effect in different disasters, there needed to be some challenges and opportunities for ecohydrology facing related disasters in various fields, such as National Space Planning, Sponge City and the ‘One Belt And One Road’ Initiative. Finally, some valuable conclusions were drawn on the application of ecohydrology to disaster prevention and mitigation. Furthermore, the key systemic settings between water management, hydrology, and ecology were described which is of the main importance for social disaster reduction, emergency management, and protection accident prevention.