EXPRESSION OF CONCERN: The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double‐blinded, placebo‐controlled trial

Ardakani, Abbas Taghavi; Farrehi, Maryam; Sharif, Mohammad Reza; Ostadmohammadi, Vahidreza; Mirhosseini, Naghmeh; Kheirkhah, Davood; Moosavi, Sayed Mojtaba; Behnejad, Milad; Reíter, Russel J.; Asemi, Zatollah

doi:10.1111/pai.12978

Cited by 37 publications

(27 citation statements)

References 42 publications

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“…Several studies have reported that melatonin ameliorates inflammatory parameters such as serum C-reactive protein (CRP) levels [94,95] as well as IL-4 and IFN-γ production [96]. Studies by Chang et al of 48 children [93] and by Ardakani et al of 70 patients with AD [97] found that melatonin administered orally may affect AD by decreasing wake time at night, reducing scratching events, and by modulating certain immune system parameters. Both studies reported decreased total serum IgE levels, while melatonin supplementation significantly improved the scoring atopic dermatitis index and total sleep time.…”

Section: Functions Of Melatonin In the Skinmentioning

confidence: 99%

Protective Effects of Melatonin on the Skin: Future Perspectives

Rusanova

Martínez-Ruiz

Florido

et al. 2019

IJMS

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When exposed to hostile environments such as radiation, physical injuries, chemicals, pollution, and microorganisms, the skin requires protective chemical molecules and pathways. Melatonin, a highly conserved ancient molecule, plays a crucial role in the maintenance of skin. As human skin has functional melatonin receptors and also acts as a complete system that is capable of producing and regulating melatonin synthesis, melatonin is a promising candidate for its maintenance and protection. Below, we review the studies of new metabolic pathways involved in the protective functions of melatonin in dermal cells. We also discuss the advantages of the topical use of melatonin for therapeutic purposes and skin protection. In our view, endogenous intracutaneous melatonin production, together with topically-applied exogenous melatonin and its metabolites, represent two of the most potent defense systems against external damage to the skin.

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Section: Functions Of Melatonin In the Skinmentioning

confidence: 99%

Protective Effects of Melatonin on the Skin: Future Perspectives

Rusanova

Martínez-Ruiz

Florido

et al. 2019

IJMS

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show abstract

“…A randomized, double‐blinded, placebo‐controlled trial assessed the effects of melatonin administration on disease severity and sleep quality in 70 children with AD [25 ]. Overall, melatonin supplementation had beneficial effects on disease severity, serum total IgE levels, and on the Children's Sleep Habits Questionnaire (CSHQ).…”

Section: Atopic Dermatitismentioning

confidence: 99%

Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)

Akdiş¹,

Bousquet²,

Grattan

et al. 2019

Clin Transl Allergy

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The European Academy of Allergy and Clinical Immunology (EAACI) supports three journals: Allergy, Paediatric Allergy and Immunology as well as Clinical and Translational Allergy. The major goals of EAACI include (i) supporting health promotion in which the prevention of allergy and asthma plays a critical role and (ii) disseminating the knowledge of allergy to all stakeholders including the EAACI junior members. Substantial progress was made in 2018 in the identification of basic mechanisms of atopic dermatitis and urticaria and the translation of these mechanisms into clinics. Many large epidemiologic studies and meta-analyses have been the highlights of the last year.

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“…The researchers administered melatonin (to 35 children vs. placebo to 35 children) at a dose of 6 mg/day for 6 weeks, which resulted in a statistically significant reduction in the severity of lesions (SCORAD, objective SCORAD) and improvement in sleep parameters (Children’s Sleep Habits questionnaire) as well as in total IgE concentration. Interestingly, the treatment did not affect the severity of itching or the inflammation parameters (CRP) [ 27 ]. Results of recent studies indicate that melatonin, also due to its multidirectional anti-inflammatory and anti-apoptotic effects, may prove to be a promising therapeutic option in patients with AD [ 28 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Melatonin and sleep disorders in patients with severe atopic dermatitis

Jaworek¹,

Jaworek²,

Szafraniec³

et al. 2021

pdia

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Introduction Many atopic dermatitis (AD) patients suffer from insomnia. Out of numerous factors associated with sleep disorders, melatonin seems to play a significant role. Aim To assess the relation between melatonin concentration and sleep disorders in adult patients with severe and very severe AD. Material and methods The study included 36 adult patients with severe and very severe AD and 20 healthy Caucasian volunteers. The severity of skin lesions was assessed by the EASI scale. Skin itch was evaluated by a visual-analogue scale (VAS), and sleep disorders were assessed by the Polish version of the Athens Insomnia Scale (AIS). Serum melatonin concentration of patients and controls was determined by ELISA. Results Melatonin concentration in patients with very severe AD was significantly ( p < 0.001) lower than in patients with severe AD, however, melatonin concentration in the group of AD patients did not differ significantly ( p = 0.33) from that observed in the control group. There was a significant negative correlation between the concentration of melatonin in the study group and the severity of itching ( R = –0.54, p < 0.001). The intensity of sleep disorders was significantly higher ( p < 0.001) in patients with a very severe form of AD compared to patients with severe AD. Moreover, there was a significant negative correlation between melatonin concentration and sleep disorders ( R = –0.67, p < 0.001). Conclusions Our results clearly showed that sleep disturbances are more expressed in very severe AD patients compared to subjects suffering from severe disease. We also suggest that melatonin serum concentration could play a role in the pathogenesis of sleep disturbances in AD patients.

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EXPRESSION OF CONCERN: The effects of melatonin administration on disease severity and sleep quality in children with atopic dermatitis: A randomized, double‐blinded, placebo‐controlled trial

Abstract: Overall, melatonin supplementation had beneficial effects on disease severity, serum total IgE levels, and CSHQ among children diagnosed with AD.

Cited by 37 publications

References 42 publications

Protective Effects of Melatonin on the Skin: Future Perspectives

Protective Effects of Melatonin on the Skin: Future Perspectives

Highlights and recent developments in skin allergy and related diseases in EAACI journals (2018)

Melatonin and sleep disorders in patients with severe atopic dermatitis

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