2016
DOI: 10.1016/j.jss.2016.08.010
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Expression of connexin 26 and connexin 43 is reduced in Hirschsprung's disease

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Cited by 9 publications
(5 citation statements)
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“…To note that whereas some papers describe Cx43 as the common connexin of both, smooth muscle cells and ICC gap junctions, [43][44][45] others reported a selective Cx43 labelling of the ICC in human bowel. [46][47][48] In our samples of mouse proximal colon, Cx43 labelling was present at the level of the MP and, to a lesser extent, at the border of the SM and in the thickness of the circular muscle layer; the labelling distribution markedly overlapped with that of the three ICC subtypes, as confirmed by the c-Kit antibody labelled twin slices.…”
Section: Discussionsupporting
confidence: 67%
“…To note that whereas some papers describe Cx43 as the common connexin of both, smooth muscle cells and ICC gap junctions, [43][44][45] others reported a selective Cx43 labelling of the ICC in human bowel. [46][47][48] In our samples of mouse proximal colon, Cx43 labelling was present at the level of the MP and, to a lesser extent, at the border of the SM and in the thickness of the circular muscle layer; the labelling distribution markedly overlapped with that of the three ICC subtypes, as confirmed by the c-Kit antibody labelled twin slices.…”
Section: Discussionsupporting
confidence: 67%
“…The connexin43 (Cx43), which widely exists between ICCs or ICCs and SMCs, is the most important protein of gap junctions in mediating synchronized contraction of SMCs and ICCs function [18,19]. Studies of Hirschsprung’s disease over the past decades have exhibited that lack of Cx43-based communication between ICCs or/and SMCs may be partly responsible for the GI motility disorders [20,21]. McClain et al [22] showed that Ca 2+ responses in enteric glia, mediated by Cx43 hemichannels, influenced gut motility and intestinal transit in mice.…”
Section: Introductionmentioning
confidence: 99%
“…Moreover, our study for the first time demonstrated that the decreased UBR4 expression also occurred in the ganglionic colon of HSCR patients. It has been shown that several aberrant gene expressions, including SK3 [9, 17], Cx26 and Cx43 [18], and NOS [19], were significantly associated with the persistent intestinal symptoms in HSCR patients after an appropriately completed surgery. Whether the aberrant UBR4 expression in the ganglionic colon is also correlated with the persistence of bowel symptoms after pull-through in HSCR patients warrants further investigation.…”
Section: Discussionmentioning
confidence: 99%