2020
DOI: 10.21521/mw.6341
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Expression of COX-2, HMGB-1 and CD68 in lung tissue in sheep fibrinous bronchopneumonia

Abstract: This study aimed to determine the expression of some cytokines, such as cyclooxygenase-2 (COX-2), High Mobility Group Box-1 (HMGB-1) and CD68, in the lung tissue of sheep with fibrinous bronchopneumonia by immunohistochemical methods. Forty sheep which had suffered from respiratory problems were brought for necropsy to the Faculty of Veterinary Medicine, Department of Pathology, Aksaray University, between November 2014 and December 2017. After necropsy, lung tissues grossly diagnosed with fibrinous bronchopne… Show more

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“…In the immunohistochemical scoring of sections, bronchial and bronchiolar epithelial cells and cells debris, peribronchial glands, interalveolar septum inflammatory cells, alveolar macrophages, and neutrophils were examined semi-quantitatively. Immunohistochemical staining scores were classified as mild (+), moderate (++) and severe (+++) expression according to the criteria determined by Yavuz and Dinçel (2020)…”
Section: Immunohistochemical Methodsmentioning
confidence: 99%
“…In the immunohistochemical scoring of sections, bronchial and bronchiolar epithelial cells and cells debris, peribronchial glands, interalveolar septum inflammatory cells, alveolar macrophages, and neutrophils were examined semi-quantitatively. Immunohistochemical staining scores were classified as mild (+), moderate (++) and severe (+++) expression according to the criteria determined by Yavuz and Dinçel (2020)…”
Section: Immunohistochemical Methodsmentioning
confidence: 99%
“…Sections were examined under a light microscope and photographed (Leica DM 400B). Immunohistochemical staining scores were classified as mild (+), moderate (++) and severe (+++) expression according to the criteria determined by Yavuz and Dinçel 27 .…”
Section: Immunohistochemical Methodsmentioning
confidence: 99%