2000
DOI: 10.1016/s0165-0173(99)00068-5
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Expression of Cx36 in mammalian neurons

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Cited by 262 publications
(184 citation statements)
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“…There are several connexin proteins including connexins 26, 32 and 36 expressed in brainstem neurons, they form gap junction between neurons and coupled electrical and chemical activity between cells (Condorelli et al 2000;Solomon et al 2001;Solomon 2003). In the present study, we have observed a group of central peaks that are distinct from the common input for two reasons: 1) their coupling efficiency is extremely high, allowing both cells to fire simultaneously, while such a high coupling efficiency cannot be achieved with chemical synapses as action potentials are usually generated with multiple (>100) unitary PSPs (Kirkwood, 1979); 2) these central peaks are highly sensitive to halothane, a blocker of gap junctions (He and Burt 2000).…”
Section: Discussionmentioning
confidence: 99%
“…There are several connexin proteins including connexins 26, 32 and 36 expressed in brainstem neurons, they form gap junction between neurons and coupled electrical and chemical activity between cells (Condorelli et al 2000;Solomon et al 2001;Solomon 2003). In the present study, we have observed a group of central peaks that are distinct from the common input for two reasons: 1) their coupling efficiency is extremely high, allowing both cells to fire simultaneously, while such a high coupling efficiency cannot be achieved with chemical synapses as action potentials are usually generated with multiple (>100) unitary PSPs (Kirkwood, 1979); 2) these central peaks are highly sensitive to halothane, a blocker of gap junctions (He and Burt 2000).…”
Section: Discussionmentioning
confidence: 99%
“…Four candidate gap junction-forming proteins [connexin36 (Cx36), connexin45 (Cx45), connexin50 (Cx50), and connexin57 (Cx57)] and two additional poreforming proteins [pannexin1 (Px1) and pannexin2 (Px2)] have been identified in central nervous system neurons (16)(17)(18)(19)(20)(21). To date, Cx36 is the only gap junction-forming protein documented in cortical GABAergic neurons, as established by ultrastructural methods (22).…”
mentioning
confidence: 99%
“…In recent years, sensitive electrophysiological techniques have also documented electrical synapses in numerous adult brain regions (Bennett and Zukin, 2004); mRNA for the gap junction protein connexin36 (Cx36) was widely detected in neurons but not glia (Condorelli et al, 1998;Condorelli et al, 2000); and Cx36 was found to be present in ultrastructurally-defined gap junctions between neurons in many regions of both developing and adult CNS (Rash et al, 2001b;Nagy et al, 2004;Li et al, 2004a;Rash et al, 2005;Kamasawa et al, 2006;Fukuda et al, 2006). Moreover, the functional importance of Cx36 in adult brain is indicated by deficits in neuronal network properties and by behavioral impairments in Cx36 knockout mice (Hormuzdi et al, 2004;Frisch et al, 2005).…”
mentioning
confidence: 99%