Expression of CXC Chemokine, IP-10/Mob-1 is Regulated by Specific p38,CAMK-II, NFÃŽÂºB and Staurosporine Regulatory Pathways in Primary Hepatocytes

Hassanshahiraviz, Gholamhossein; Asar, Shokrollah; Arababadi, Mohammad Kazemi; Sheikholeslami, Nazanin Zia; Dickson, Alan J.

doi:10.3923/rji.2008.21.28

Cited by 2 publications

(1 citation statement)

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“…Chemokines are further subdivided into C, CC, CX3C and CXC subgroups according to the position of conserved cysteine motifs in their structure [14]. CXCL10 (interferon-γ-inducible protein 10, previously called IP-10) was initially discovered as a chemokine which is induced by interferon (IFN)-γ and is produced by a wide range of cell types including monocytes [15], neutrophils [16], endothelial cells [17], keratinocytes [18], fibroblasts [19], mesenchymal cells [20], dendritic cells [21], hepatocytes [22] and astrocytes [23]. CXCL10 binds to CXCR3, which is discussed in the next section.…”

Section: Introductionmentioning

confidence: 99%

The Biological Functions, Structure and Sources of CXCL10 and Its Outstanding Part in the Pathophysiology of Multiple Sclerosis

Vazirinejad¹,

Ahmadi

Arababadi

et al. 2014

Neuroimmunomodulation

143

100

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The etiology of several autoimmune diseases, including multiple sclerosis (MS), has still not been completely clarified. MS is defined as an autoimmune disease with clinical features of a chronic, inflammatory and demyelinating autoimmune disorder which affects the central nervous system. The course of the disease includes phases of remission and relapses which can be exacerbated in both severity and duration. Chemokines, which are a subfamily of the cytokines, act as chemoattractants for a wide variety of cells, including immune cells. CXCL10 is a small protein that is defined as an ‘inflammatory' chemokine and binds to CXCR3 to mediate immune responses through the activation and recruitment of leukocytes such as T cells, eosinophils, monocytes and NK cells. The aim of this review is to address recent findings regarding the relationship between CXCL10 and MS.

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