Expression of Cyclin D1 in Cutaneous Xanthogranuloma and Solitary Reticulohistiocytoma

Saggini, Andrea; Cerroni, Lorenzo; Ortins-Pina, Ana; Kraft, Stefan

doi:10.1097/dad.0000000000002186

The American Journal of Dermatopathology

2022

DOI: 10.1097/dad.0000000000002186

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Expression of Cyclin D1 in Cutaneous Xanthogranuloma and Solitary Reticulohistiocytoma

Andrea Saggini

Lorenzo Cerroni

Ana Ortins-Pina

et al.

Abstract: Squamomelanocytic tumor of the nail unit metastasizing to a sentinel lymph node: a dermoscopic and histologic investigation.

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2024

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Plexiform fibrohistiocytic tumor: A series of 10 case studies

Wang,

Ma,

et al. 2024

American Journal of Clinical Pathology

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Objectives We sought to investigate the clinicopathologic features and differential diagnosis of plexiform fibrohistiocytic tumor (PFHT) and its pathogenesis. Methods Ten cases of PFHT were collected from Xi Jing Hospital, Fourth Military Medical University, from September 2008 to December 2022 for clinical data as well as microscopic and immunohistochemical observation. CCND1 gene amplification and break were assayed by fluorescence in situ hybridization (FISH). Results We report 10 cases of PFHT according to histologic classification. Seven cases were of histiocytoid type, and 3 had mucous degeneration in the nodules. One case was of fibroblastic type, which was mainly composed of fibroblast-like cells. Two cases were of mixed type. Immunohistochemically, the osteoclast-like multinucleated giant cells, histiocyte-like cells, and occasional spindle cells in the adjacent fascicles were reactive for CD68 (10/10), CD163 (5/8), CD10 (8/8), cyclin D1 (8/8), CDK4 (5/8), β-catenin (4/6), MITF (2/6), and PGP9.5 (4/5). Vimentin (9/9) was strongly positive in tumor cells and peripheral fibroblast-like cells. The positive index of Ki-67 was 5% to 40%, with an average of 20%. The FISH analysis showed neither amplification nor break of the CCND1 gene. All cases underwent surgical resection, and patients were followed up for 9 months to 11 years. Only 2 cases recurred. Conclusions Plexiform fibrohistiocytic tumor is a low-grade malignant soft tissue neoplasm. The diagnosis mainly depends on histopathologic and immunohistochemical markers. Cyclin D1 and CD10 expression has diagnostic value for the diagnosis and differential diagnosis of PFHT combined with its plexiform morphology. The overexpression of cyclin D1 suggests an involvement of cell cycle regulatory genes in the pathogenesis of PFHT.

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Plexiform fibrohistiocytic tumor: A series of 10 case studies

Wang,

Ma,

et al. 2024

American Journal of Clinical Pathology

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Expression of Cyclin D1 in Cutaneous Xanthogranuloma and Solitary Reticulohistiocytoma

Abstract: Squamomelanocytic tumor of the nail unit metastasizing to a sentinel lymph node: a dermoscopic and histologic investigation.

Cited by 1 publication

References 11 publications

Plexiform fibrohistiocytic tumor: A series of 10 case studies

Plexiform fibrohistiocytic tumor: A series of 10 case studies

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