Expression of cyclooxygenase-2 and DNA topoisomerase II α in precancerous and cancerous lesions of the oral mucosa

Segawa, Emi; Sakurai, Kazuo; Kishimoto, Hiroyuki; Takaoka, Kazuki; Noguchi, Kazuma; Hashitani, Susumu; Hirota, Seiichi; Urade, Masahiro

doi:10.1016/j.oraloncology.2007.08.014

Cited by 18 publications

(22 citation statements)

References 29 publications

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“…This finding was in similar lines with several studies where the expression of this biomarker was studied [5,17,[23][24][25]. This observation suggests that upregulation of COX-2 may have an important role to play in the progression of OSCC.…”

Section: Discussionsupporting

confidence: 90%

“…The expression of COX-2 was seen to be absent in all the 10 specimens of normal oral mucosa, a finding similar to that made by Segawa et al [17] and Mauro et al [18]. However, among the 14 cases of dysplastic lesions a majority of the cases expressed COX-2, which is in line with the suggestion made by Mauro et al (18) that the expression progresses from normal to dysplasia to carcinoma.…”

Section: Discussionsupporting

confidence: 89%

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Cyclooxygenase-2 – An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study

Byatnal

Sen

et al. 2015

Pathol. Oncol. Res.

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Oral squamous cell carcinoma (OSCC) is the most common head and neck squamous cell carcinoma (HNSCC) with metastasis and tumor recurrence resulting in 90 % of cancer associated mortality. COX-2, an inflammatory biomarker, has been shown to play a significant role in tumorigenesis of OSCC. To study the expression of COX-2 in OSCC by immunohistochemistry and investigate its association with the clinicopathological parameters including patient survival. A cross sectional study was carried out in 75 histologically confirmed cases of OSCC. COX-2 expression was evaluated by indirect streptavidin biotin method. The expression was semi-quantitatively assessed using established criteria. The expression profile of COX-2 was correlated with the clinicopathological details like tumor size, regional lymphnode metastasis, distant metastasis, clinical stage, local recurrence of tumor, histological grade, and survival of patient. Chi square and Kaplan Meier statistical tests were applied for assessing this association. COX-2 expression was absent in normal oral mucosa. Over expression of COX-2 was seen in 58 out of 75 specimens of OSCC. Overexpression of COX-2 was significantly associated with the lymphnode involvement, histological grade, local recurrence of tumor and patient survival. COX-2 expression represents an important biomarker of prognostic significance that may be used to identify a subset of patients at high risk and to predict patient survival.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 89%

Cyclooxygenase-2 – An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study

Byatnal

Sen

et al. 2015

Pathol. Oncol. Res.

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“…The studies have also confirmed that COX-2 can modulate the expression of GST-π, P-gp and TopoIIα (Segawa et al, 2008;Sui et al, 2011). The results in this study displayed that in observation group, COX-2 expression in cancer tissue had a significantly-positive correlation with GST-π and P-gp, but a negative correlation with TopoIIα.…”

Section: Discussionsupporting

confidence: 79%

Sensitivity of Gastric Cancer Cells to Chemotherapy Drugs in Elderly Patients and Its Correlation with Cyclooxygenase-2 Expression

Qiu¹,

Qiu²

2015

Asian Pacific Journal of Cancer Prevention

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“…While the overexpression of COX-2 in oral cancer has been widely reported and is generally accepted by the scientific community, there are contrasting opinions on the possibility that COX-2 expression could be used as a prognostic tool to predict the outcome of the disease; some author report a correlation between COX-2 overexpression and poor prognosis [39] while others don't [40]. Moreover, opinions regarding the correlation between COX-2 expression and the histologic grade of oral cancer are highly conflicting; many authors report a progressive increase of COX-2 expression from normal oral mucosa towards invasive carcinoma [39,[41][42][43], others report an higher COX-2 expression in premalignant lesion than in malignancies [4,6,[44][45], while others report the lack of correlation between COX-2 level and tumor stage or grade [7,46].…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, opinions regarding the correlation between COX-2 expression and the histologic grade of oral cancer are highly conflicting; many authors report a progressive increase of COX-2 expression from normal oral mucosa towards invasive carcinoma [39,[41][42][43], others report an higher COX-2 expression in premalignant lesion than in malignancies [4,6,[44][45], while others report the lack of correlation between COX-2 level and tumor stage or grade [7,46].…”

Section: Discussionmentioning

confidence: 99%

Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.

Mauro

Lipari²,

Leone

et al. 2011

Folia Histochem Cytobiol.

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Cyclooxigenase (COX) is the rate-limiting enzyme for the conversion of arachidonic acid (AA) to prostaglandins (PGs). Two isoforms of COX have been identified: COX-1 is constitutively expressed in many cells and is involved in cell homeostasis, angiogenesis and cell-cell signalling; COX-2 is not expressed in normal condition however it is strongly expressed in inflammation. The oral cavity is costantly exposed to physical and chemical trauma that could lead to mucosal reactions such as hyperplasia, dysplasia and cancer. Early diagnosis is the most important issue to address for a positive outcome of oral cancer; therefore it would be useful to identify molecular markers whose expression is associated with the various stages of oral cancer progression. Since COX enzyme has been involved, with different mechanisms, in the development and progression of malignancies we decided to investigate the expression and localization of COX-1 and COX-2 in normal human oral mucosa and three different pathologies (hyperplasia, dysplasia and carcinoma) by immunohistochemistry and RT-PCR. COX-1 mRNA and protein have been detected already in normal oral mucosa and their expression progressively increases from normal samples towards hyperplasia, dysplasia and finally carcinoma. On the contrary, COX-2 is not expressed in the normal tissue, starts to be expressed in hyperplasia, reaches the maximum activation in dysplasia and then starts to be downregulated in carcinoma.

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Expression of cyclooxygenase-2 and DNA topoisomerase II α in precancerous and cancerous lesions of the oral mucosa

Cited by 18 publications

References 29 publications

Cyclooxygenase-2 – An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study

Cyclooxygenase-2 – An Imperative Prognostic Biomarker in Oral Squamous Cell Carcinoma- An Immunohistochemical Study

Sensitivity of Gastric Cancer Cells to Chemotherapy Drugs in Elderly Patients and Its Correlation with Cyclooxygenase-2 Expression

Expression of cyclooxygenase-1 and cyclooxygenase-2 in normal and pathological human oral mucosa.

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