Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression

Cressey, Ratchada; Pimpa, Sarunya; Tontrong, Waragorn; Watananupong, Onusa; Leartprasertsuke, Nirush

doi:10.1016/j.canlet.2005.03.023

Cited by 20 publications

(14 citation statements)

References 29 publications

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“…These findings are in agreement with those reported by other authors, 22,[43][44][45][46] who speculate that COX-2 might exert a crucial role in early carcinogenesis and in the acquisition of a neoplastic phenotype by PGE 2 -mediated induction of the Bcl2 protoncogene. 47 However, according to these authors, invasiveness and metastatic potential would require not only COX-2 mediated angiogenesis 4,17 but also other genes and proteins, such as MT1-MMP and MMP-2.…”

Section: Discussionsupporting

confidence: 95%

5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage

Barresi¹,

Grosso²,

Vitarelli³

et al. 2007

Diseases of the Colon &Amp; Rectum

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Section: Discussionsupporting

confidence: 95%

5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage

Barresi¹,

Grosso²,

Vitarelli³

et al. 2007

Diseases of the Colon &Amp; Rectum

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“…In the present study, 54% of the studied cases with CRC, were males and 46% were females, The results are in accordance with some studies (8,11,18,31,32), but differ from the findings of Cressey et al (2006) who reported that females had a higher incidence in their study (33).…”

Section: Discussionsupporting

confidence: 81%

Immunohistochemical Study of HER2/neu Expression in Colorectal Cancer and its Relation to other Clinicopathological Criteria and Prognostic Factors

et al. 2017

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Background: Human epidermal growth factor receptor 2 (HER2) overexpression and amplification have been studied as a therapeutic and prognostic target in a number of tumors although conflicting data exist about the incidence and clinical consequence of HER2/neu status in the patients with colorectal cancer. The aim of the present study was to evaluate the immunohistochemical expression of HER2/neu and its relationship with clinicopathological parameters and prognostic factors. Methods: This study involved 50 specimens of malignant colorectal cancer lesions and HER-2/neu expression was evaluated by the Hercep-Test Kit. Results: Out of 50 cases, most of them (76%) were HER2/neu negative and in 12 (24%) cases, HER2/neu positive immunostaining were detected. 24% (n = 12), 36% (n = 18), 30% (n = 15), and 10% (n = 5) were scored as 3+, 2+, 1+, and 0 respectively. No significant association was noted between HER-2/neu expression and patients' age, tumor size, gender, location, grade and stage (P > 0.05). Conclusions:The immunohistochemical evaluation of HER2/neu overexpression for potential targeted anti-HER2 therapy may not be valuable for the patients with colorectal cancer and also studies with larger sample sizes using standardized tests are needed to understand the exact biologic role of HER-2/neu in this type of tumor.

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“…Moreover, the prognostic role of COX-2 in colorectal cancer should be examined in the context with other molecular markers. Some studies included in the meta-analysis had already addressed the association of COX-2 with other markers, such as peroxisome proliferator–activated receptors [31], p53 [32], β-catenin [33], VEGF [34].…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature

et al. 2013

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BackgroundCyclooxygenase-2 (COX-2) is believed to be an important enzyme in the pathogenesis of colorectal cancer (CRC). Correlations between the expression of COX-2 with tumor growth and distant metastasis have become an issue; thus, attention has been paid to COX-2 as a prognostic factor. Various studies examined the relationship between COX-2 immunohistochemistry (IHC) overexpression with the clinical outcome in patients with colorectal cancer, but yielded conflicting results. The prognostic significance of COX-2 overexpression in colorectal cancer remains controversial.MethodsElectronic databases updated to October 2012 were searched to find relevant studies. A meta-analysis was conducted with eligible studies which quantitatively evaluated the relationship between COX-2 overexpression and survival of patients with colorectal cancer. Survival data were aggregated and quantitatively analyzed.ResultsWe performed a meta-analysis of 23 studies (n = 4567 patients) that evaluated the correlation between COX-2 overexpression detected by IHC and survival in patients with colorectal cancer. Combined hazard ratios suggested that COX-2 overexpression had an unfavorable impact on overall survival (OS) (HR [hazard ratio] = 1.193, 95% CI [confidence interval]: 1.02 ∼ 1.37), but not disease free survival (DFS) (HR = 1.25, 95% CI: 0.99 ∼ 1.50) in patients with colorectal cancer.ConclusionsCox-2 overexpression in colorectal cancer detected by IHC appears to have slightly worse overall survival. However, the prognostic value of COX-2 on survival in colorectal cancer still needs further large-scale prospective trials to be clarified.

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Expression of cyclooxygenase-2 in colorectal adenocarcinoma is associated with p53 accumulation and hdm2 overexpression

Cited by 20 publications

References 29 publications

5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage

5-Lipoxygenase is Coexpressed with Cox-2 in Sporadic Colorectal Cancer: A Correlation with Advanced Stage

Immunohistochemical Study of HER2/neu Expression in Colorectal Cancer and its Relation to other Clinicopathological Criteria and Prognostic Factors

Prognostic Significance of COX-2 Immunohistochemical Expression in Colorectal Cancer: A Meta-Analysis of the Literature

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