Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas

Jiang, Jian-Gang; Tang, Jiang-bo; Chen, Chun-Lian; Liu, Baoxing; Fu, Xiangning; Zhu, Zhihui; Qu, Wei; Cianflone, Katherine; Waalkes, Michael P.; Wang, Dao Wen

doi:10.3748/wjg.v10.i15.2168

Cited by 11 publications

(9 citation statements)

References 36 publications

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“…A score was calculated by multiplication of staining intensity with the amount of positive cells: weak 0 to 3, moderate 4 to 8, and strong 9 to 12. 14 Immunohistochemistry staining for activated NF-KB was performed with the NF-KB p65 (F-6) monoclonal antibody (Santa Cruz Biotechnology). Only nuclear immunoreactivity was considered positive for NF-KB.…”

Section: Immunohistochemistrymentioning

confidence: 99%

COX-2 and NF-KB Overexpression Is Common in Pancreatic Cancer but Does Not Predict for COX-2 Inhibitors Activity in Combination With Gemcitabine and Oxaliplatin

Cascinu¹,

Scartozzi²,

Carbonari³

et al. 2007

American Journal of Clinical Oncology

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Section: Immunohistochemistrymentioning

confidence: 99%

COX-2 and NF-KB Overexpression Is Common in Pancreatic Cancer but Does Not Predict for COX-2 Inhibitors Activity in Combination With Gemcitabine and Oxaliplatin

Cascinu¹,

Scartozzi²,

Carbonari³

et al. 2007

American Journal of Clinical Oncology

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“…induced skin papillomas than control mice (18,19). However, in the tumor promotion potential of TPA, the role of COX-2 still remains unknown.…”

Section: Introductionmentioning

confidence: 99%

A JNK1/AP-1–Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate–Induced Cell Transformation through Regulating Cell Cycle Progression

Zhang

Li²,

Song³

et al. 2008

Molecular Cancer Research

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“…COX-2 knockout mice developed ∼75% fewer chemically induced skin papillomas than control mice (27). The present study provides evidence that arsenite can induce COX-2 expression and PGE 2 production in JB6 P+ cells.…”

Section: Discussionmentioning

confidence: 99%

Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction

Lee

Bode

et al. 2009

Cancer Research

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Arsenite is a well-known human carcinogen that especially targets skin. The tumor progression locus 2 (Tpl2) gene encodes a serine/threonine protein kinase that is overexpressed in various cancer cells. However, the relevance of Tpl2 in arsenite-induced carcinogenesis and the underlying mechanisms remain to be explored. We show that arsenite increased Tpl2 kinase activity and its phosphorylation in mouse epidermal JB6 P+ cells in a dose-and time-dependent manner. Exposure to arsenite resulted in a marked induction of cyclooxygenase-2 (COX-2) and prostaglandin E 2 (PGE 2 ), important mediators of inflammation and tumor promotion. Treatment with a Tpl2 kinase inhibitor or Tpl2 short hairpin RNA suppressed COX-2 expression and PGE 2 production induced by arsenite treatment, suggesting that Tpl2 is critical in arsenite-induced carcinogenesis. We also found that arsenite-induced phosphorylation of extracellular signalregulated kinases (ERK) or c-Jun NH 2 -terminal kinases (JNK) was markedly suppressed by Tpl2 kinase inhibitor or Tpl2 short hairpin RNA. Inhibition of arsenite-induced ERK or JNK signaling using a pharmacologic inhibitor of ERK or JNK substantially blocked COX-2 expression. Furthermore, inhibition of Tpl2 reduced the arsenite-induced promoter activity of NF-KB and activator protein-1 (AP-1), indicating that NF-KB and AP-1 are downstream transducers of arsenite-triggered Tpl2. Our results show that Tpl2 plays a key role in arseniteinduced COX-2 expression and PGE 2 production and further elucidate the role of Tpl2 in arsenite signals that activate ERK/JNK and NF-KB/AP-1 in JB6 P+ cells. [Cancer Res 2009;69(20):8043-9]

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Expression of cyclooxygenase-2 in human esophageal squamous cell carcinomas

Abstract: AIM:To determine whether cyclooxygenase-2 (COX-2) was expressed in human esophageal squamous cell carcinoma.

Cited by 11 publications

References 36 publications

COX-2 and NF-KB Overexpression Is Common in Pancreatic Cancer but Does Not Predict for COX-2 Inhibitors Activity in Combination With Gemcitabine and Oxaliplatin

COX-2 and NF-KB Overexpression Is Common in Pancreatic Cancer but Does Not Predict for COX-2 Inhibitors Activity in Combination With Gemcitabine and Oxaliplatin

A JNK1/AP-1–Dependent, COX-2 Induction Is Implicated in 12-O-Tetradecanoylphorbol-13-Acetate–Induced Cell Transformation through Regulating Cell Cycle Progression

Tpl2 Is a Key Mediator of Arsenite-Induced Signal Transduction

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