Expression of cyclooxygenases and trophic and growth factors in epiretinal membranes at late stages of proliferative vitreoretinopathy

Tikhonovich, Marina; Lyskin, P.V.; Ioyleva, E.E.; Гаврилова, С.А.

doi:10.1007/s00417-016-3445-4

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…On the other hand, prostaglandins can also lead to the increased synthesis of COX-2 by positive feedback mechanism [78]. Previous studies have confirmed that the expression COX-1 and COX-2 was detectable in the proliferative membranes of PVR patients [79]. At the early stages of PVR development, the administration of lornoxicam, known as nonsteroidal anti-inflammatory drugs (NSAIDs), could not only inhibit the expression of COXs in the retina and choroid, but also reduce the frequency of membrane formation by 31-43% in PVR models [77].…”

Section: Other Mediators: Arachidonic Acid Metabolitementioning

confidence: 94%

Inflammatory mediators of proliferative vitreoretinopathy: hypothesis and review

Dai

Sun

2020

Int Ophthalmol

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Purpose To review the role of inflammatory mediators in proliferative vitreoretinopathy (PVR) development and the current treatment for PVR prevention. Methods A PubMed search was carried out using these keywords “PVR,” “inflammatory mediators,” “growth factors,” “cytokines” and “treatment.” Studies regarding inflammatory mediators and PVR therapy were included and published up to December 2019. Results Inflammatory mediators, namely growth factors and cytokines, have been implicated in the occurrence and development of PVR. Among various inflammatory mediators, transforming growth factor-β, platelet-derived growth factor, interleukin-6, interleukin-8 and tumor necrosis factor-α are considered to be particularly important. In this review, we focus on the hypothesis that growth factors and cytokines are involved in the development of PVR, and current treatment for the prevention of PVR. Conclusion We support the hypothesis that growth factors and cytokines may participate in the complex process of PVR development. More importantly, the identification of inflammatory mediators provides novel and efficacious therapeutic targets for the treatment of PVR.

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Section: Other Mediators: Arachidonic Acid Metabolitementioning

confidence: 94%