Expression of Cytokeratin 7, 20, 14 in Urothelial Carcinoma and Squamous Cell Carcinoma of the Egyprian Urinary Bladder Cancer

Hammam, Olfat; Wishahi, Mohamed; Khalil, Heba M. A.; GANZOURI, HOSSAM EL; Badawy, Mohamed; Elkhouly, Amr; Elesaily, Khaled

doi:10.21608/jesp.2014.90369

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…IHC revealed a CK7+/CK20‐ pattern in the tumor. CK7 and CK20 are both generally positive in UC and negative in SCC 12,13 . CK7 expression is preserved in high‐grade UC including squamous differentiation, 14 whereas CK20 expression is attenuated 13,14 .…”

Section: Discussionmentioning

confidence: 97%

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Squamous cell and urothelial carcinomas in an ileal neobladder

Fujimoto¹,

Sakamoto²,

Sakurai

et al. 2022

IJU Case Reports

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Section: Discussionmentioning

confidence: 97%

“…CK7 and CK20 are both generally positive in UC and negative in SCC. 12,13 CK7 expression is preserved in high-grade UC including squamous differentiation, 14 whereas CK20 expression is attenuated. 13,14 These results suggest that SCC more likely to be differentiated from UC than did de novo.…”

Section: Discussionmentioning

confidence: 99%

Squamous cell and urothelial carcinomas in an ileal neobladder

Fujimoto¹,

Sakamoto²,

Sakurai

et al. 2022

IJU Case Reports

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“…High-grade stage Ta or T1 disease requires repeat resection due to under-staged or persistent disease. Intermediate-risk and high-risk patients receive intravesical therapy unless upstaging to muscleinvasive disease occurs on repeat resection [ 4,5 ] . The aim of this study was to show the efficacy of enhanced recovery after surgery protocol in management of patients undergoing radical cystectomy for bladder cancer with intestinal incorporation in urinary diversion and to compare the complication rate of this protocol to the standard one.…”

Section: Introductionmentioning

confidence: 99%

Ninety Days complications rate in patients undergoing radical cystectomy with enhanced recovery protocol

Hasan,

AbdelRazek,

Elamir

et al. 2024

Int J Chem Biochem Sci

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Bladder cancer is a carcinoma of the urothelial, or “umbrella,” cells that line the lumen of the urinary bladder. Technically, urothelial carcinoma includes tumors of the bladder, upper urinary tract (renal pelvis and ureters), and proximal urethra. Bladder cancer accounts for approximately 90% to 95% of urothelial carcinoma; bladder cancer comprises 75% pure urothelial carcinoma and 25% “variant” histology, adding complexity to the management of this disease. Bladder cancer can be categorized in several way, almost all bladder cancers originate in the urothelium, which is a 3- to 7-cell mucosal layer within the muscular bladder. Squamous cell carcinoma of the bladder can involve multiple sites; however, the lateral wall and trigone are more commonly involved by this tumor. All small cell carcinomas of the urinary system identified so far have been located in the urinary bladder, most commonly in the dome and vesical lateral wall. Radical cystectomy is a crucial surgical technique in managing MIBC, high-risk NMIBC, and treatment-refractory NMIBC. Despite a high perioperative mortality rate (5-10%), it now carries a 1-2% mortality rate due to improvements in surgical technique, intensive care medicine evolution, and antibiotic availability.

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“…abnormal growth of bladder cells and is a common cancer, occurring more often in men, and showing a higher recurrence rate than any other malignancy. [4][5][6][7] It can be classified as either as a transitional cell carcinoma (accounting for approximately 90% of cases), [8][9][10] a squamous cell carcinoma, [11][12][13] an adenocarcinoma, 14,15 sarcoma, 16,17 or a small cell carcinoma (accounting for approximately 10% of cases). [18][19][20] Symptoms include painless gross hematuria, irritative bladder symptoms, pelvic or bony pain, lower extremity edema, or flank pain, among others.…”

mentioning

confidence: 99%

Differential expression profile analysis of lncRNA UCA1α regulated mRNAs in bladder cancer

Wang

Zhang

et al. 2017

J of Cellular Biochemistry

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Urothelial carcinoma associated 1α (UCA1α) is a novel long non-coding RNA (lncRNA) that regulates bladder cancer proliferation, migration, and invasion. The target genes of UCA1α have, however, not been identified. To address this, a pCDNA3.1(+)-UCA1α over-expression vector was transfected into UM-UC-2 bladder cancer cells. Genes differentially expressed between pCDNA3.1(+)-UCA1α and pCDNA3.1(+) transfected cell were then detected by microarray and bioinformatics analysis. A total of 71 differentially expressed genes were identified, including 52 up-regulated genes and 19 down-regulated genes. As expected, the lncRNA UCA1α expression level was significantly increased when compared to that of pCDNA3.1(+) transfected cells. The five most significantly up-regulated and five most significantly down-regulated genes were selected, and their expression levels were also assessed by real time quantitative polymerase chain reaction and Western blot. The mRNA and protein expression levels of FOXI3 and GSTA3 were found to be significantly increased, and those of MED18 and TEX101 were found to be significantly decreased. Gene ontology (GO) clustering identified several significant biological processes, cellular components, and molecular functions, associated with lncRNA UCA1α over-expression. The differentially expressed genes were involved in several significant pathways as shown by Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway clustering. Cell proliferation activity was significantly increased following overexpression of lncRNA UCA1α increasing over culture time. The present study identifies, for the first time, potential target genes for lncRNA UCA1α in bladder cancer, and provides a significant reference for studying the role of lncRNA UCA1α in bladder cancer.

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Expression of Cytokeratin 7, 20, 14 in Urothelial Carcinoma and Squamous Cell Carcinoma of the Egyprian Urinary Bladder Cancer

Cited by 4 publications

References 14 publications

Squamous cell and urothelial carcinomas in an ileal neobladder

Squamous cell and urothelial carcinomas in an ileal neobladder

Ninety Days complications rate in patients undergoing radical cystectomy with enhanced recovery protocol

Differential expression profile analysis of lncRNA UCA1α regulated mRNAs in bladder cancer

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