2020
DOI: 10.29252/jommid.8.1.7
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Expression of Cytokine Genes in Leishmania major-Infected BALB/c Mice Treated with Mesenchymal Stem Cells

Abstract: Introduction: Cutaneous leishmaniasis (CL) is an infectious disease with a high rate of prevalence worldwide. No effective vaccine is now available for CL, and the current chemotherapy ensues serious side effects. The potency of Mesenchymal stem cells (MSCs) in immunomodulatory and wound healing have shown promise for the treatment of CL. Methods: In the present study, BALB/c mice were infected with leishmania major promastigotes and then injected with 1×10 6 MSCs at the lesion sites. After 10, 20, and 30 days… Show more

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Cited by 3 publications
(1 citation statement)
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“…38 In addition, Hamoon Navard et al, demonstrated an increase in IL-10 and TNF.α in the spleen and liver of mice infected with L. major following MSC injection. 39 The pro-inflammatory activity of MSCs during parasite infection was indicated by a rise in TNF-α and IL-6 production as well as a concurrent decline in TGF-β. An increase in IL-10 may be a compensatory mechanism to limit this inflammation.…”
Section: Discussionmentioning
confidence: 99%
“…38 In addition, Hamoon Navard et al, demonstrated an increase in IL-10 and TNF.α in the spleen and liver of mice infected with L. major following MSC injection. 39 The pro-inflammatory activity of MSCs during parasite infection was indicated by a rise in TNF-α and IL-6 production as well as a concurrent decline in TGF-β. An increase in IL-10 may be a compensatory mechanism to limit this inflammation.…”
Section: Discussionmentioning
confidence: 99%