Expression of DJ-1 in Endometrial Cancer

Shu, Kuanyong; Xiao, Zhongqing; Long, Shenggen; Yan, Jiajia; Yu, Xiaohong; Zhu, Qi-Zhou; Tong, Mei Song

doi:10.1097/igc.0b013e3182959182

Cited by 18 publications

(5 citation statements)

References 23 publications

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“…The expression of PARK7 is also upregulated in patients with endometrial cancer (EC), and its expression is significantly associated with the pathological progression of EC, including lymph node metastasis, invasion, and differentiation [60][61][62]. Proteomic analysis revealed that the levels of PARK7 are increased in several types of cancer, and O-acetylglucosamine (GlcNAc)-modified PARK7 is involved in the pathogenesis of colorectal cancer (CRC) and human scirrhous-type gastric carcinoma (GC) [63][64][65][66].…”

Section: Role Of Park7 In Cancer Progressionmentioning

confidence: 99%

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Jin

2020

JCM

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The expression of PARK7 is upregulated in various types of cancer, suggesting its potential role as a critical regulator of the pathogenesis of cancer and in the treatment of cancer and neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, and Huntington disease. PARK7 activates various intracellular signaling pathways that have been implicated in the induction of tumor progression, which subsequently enhances tumor initiation, continued proliferation, metastasis, recurrence, and resistance to chemotherapy. Additionally, secreted PARK7 has been identified as a high-risk factor for the pathogenesis and survival of various cancers. This review summarizes the current understanding of the correlation between the expression of PARK7 and tumor progression.

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Section: Role Of Park7 In Cancer Progressionmentioning

confidence: 99%

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Jin

2020

JCM

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“…Recently, Shu K [8] showed that DJ-1 is an oncogene with abnormally high expression in EC and is closely associated with lymph node metastasis, the degree of differentiation and the invasion depth of EC. Notably, silencing DJ-1 expression by RNAi in EC inhibited cell viability and promoted cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“…The DJ-1 protein participates in various cellular processes in the form of dimers, such as gene transcription regulation, anti-oxidative stress, inhibition of apoptosis, molecular chaperone, and promoting cell proliferation [4][5][6][7]. According to a recent study [8], the expression of DJ-1 protein in EC, which is markedly higher than in normal endometrial tissue, is related to the degree of differentiation, invasion depth, and lymph node metastasis of EC. In addition, silencing DJ-1 expression by RNAi in EC cells could clearly promote cell apoptosis and inhibit cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

DJ-1 activates the noncanonical NF-κB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells

et al. 2021

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Endometrial cancer is generally one of the most evident malignant tumours of the female reproductive system, and the mechanisms underlying its cell proliferation and apoptosis are key to research in gynaecological oncology. In the paper, the in-depth molecular mechanism by which DJ-1 protein regulates the proliferation and apoptosis of Ishikawa cells was investigated. DJ-1 knockdown and overexpressing Ishikawa stable cell lines were established by lentiviral transduction. The levels of DJ-1 and noncanonical NF-κB signaling proteins were evaluated by Western blotting. Cell counting kit-8 (CCK-8) and ow cytometry were applied to analyze the cell viability and apoptosis. Co-immunoprecipitation experiment was utilized to assess the DJ-1-Cezanne interaction. The results showed that DJ-1 overexpression conferred apoptosis resistance and high proliferation on Ishikawa cells, while DJ-1 knockdown in Ishikawa cells produced the opposite results. These ndings again suggested that DJ-1 inhibits the apoptosis and promotes the proliferation of Ishikawa cells. More crucially, further data showed that the noncanonical NF-κB activation was required for the regulation of Ishikawa cell proliferation and apoptosis by DJ-1. Meanwhile, it was found that noncanonical NF-κB pathway may be activated by DJ-1 interacting with and negatively regulating Cezanne in Ishikawa cells. Overall, this work revealed that DJ-1 associates with and negatively regulates Cezanne and consequently triggers the noncanonical NF-κB activation, thereby regulating Ishikawa cell proliferation and apoptosis.

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“…Recently, Shu et al reported that DJ-1 is abnormally expressed in an endometrial cancer sample and is closely associated with the degree of differentiation, metastasis, and invasion [63]. Silencing of DJ-1 in Ishikawa cells causes cell viability inhibition and promotes apoptosis.…”

Section: Dj-1 Regulates the Non-canonical Nf-κb Pathwaymentioning

confidence: 99%

Moving beyond the Tip of the Iceberg: DJ-1 Implications in Cancer Metabolism

Olivo

Chimia

Ceramella

et al. 2022

Cells

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DJ-1, also called Parkinson’s protein 7 (PARK7), is ubiquitously expressed and plays multiple actions in different physiological and, especially, pathophysiological processes, as evidenced by its identification in neurodegenerative diseases and its high expression in different types of cancer. To date, the exact activity of DJ-1 in carcinogenesis has not been fully elucidated, however several recent studies disclosed its involvement in regulating fundamental pathways involved in cancer onset, development, and metastatization. At this purpose, we have dissected the role of DJ-1 in maintaining the transformed phenotype, survival, drug resistance, metastasis formation, and differentiation in cancer cells. Moreover, we have discussed the role of DJ-1 in controlling the redox status in cancer cells, along with the ability to attenuate reactive oxygen species (ROS)-dependent cell death, as well as to mediate ferropotosis. Finally, a mention to the development of therapeutic strategies targeting DJ-1 has been done. We have reported the most recent studies, aiming to shed light on the role played by DJ-1 in different cancer aspects and create the foundation for moving beyond the tip of the iceberg.

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Expression of DJ-1 in Endometrial Cancer

Abstract: High DJ-1 expression seems to be negatively correlated with apoptosis. Meanwhile, it may be part of the mechanisms for the development, invasion, and metastasis in endometrial cancer.

Cited by 18 publications

References 23 publications

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

Novel Insights into PARK7 (DJ-1), a Potential Anti-Cancer Therapeutic Target, and Implications for Cancer Progression

DJ-1 activates the noncanonical NF-κB pathway via interaction with Cezanne to inhibit the apoptosis and promote the proliferation of Ishikawa cells

Moving beyond the Tip of the Iceberg: DJ-1 Implications in Cancer Metabolism

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