Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas

Ugrappa, Sridevi; Jain, Ajay; Velpula, Nagalaxmi; Kumar, Ugrappa Vijay; Goyal, Stuti

doi:10.4103/1305-7456.163238

Cited by 41 publications

(57 citation statements)

References 22 publications

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“…13 Many authors have suggested that low E-cadherin immunoexpression could indicate tumor progression in leukoplakia. 7,8,15,16 This finding is in line with Santos-García et al, 15 in which 20% of leukoplakias with epithelial dysplasia and 73% of carcinomas in situ and microinvasive carcinoma had poor E-cadherin expression. Our results corroborate those of previous studies, since we observed that the expression of E-cadherin is in agreement with the severity of epithelial changes observed in leukoplakia and dysplastic oral leukoplakia showed lower immunocytochemical expression of this molecule than non-dysplastic leukoplakia.…”

Section: Resultssupporting

confidence: 80%

“…Some studies have indicated a reduction in the immunohistochemical expression of this molecule in early stages and during the progression of oral cancer. 7,8 Proteins involved in the terminal differentiation of keratinocytes, such as involucrin, have also been found to have a low expression in biopsy tissues in leukoplakia associated with epithelial dysplasia when compared with oral mucosal cells exposed or not to carcinogens. 9 The immunoexpression of these cell adhesion and differentiation markers has been investigated in different stages of carcinogenesis in biopsy tissues, but there are no studies on the expression of these proteins using cytopathological analysis of the oral mucosa.…”

Section: Introductionmentioning

confidence: 99%

“…The expression of markers associated with cell adhesion (e.g., E-cadherin) and with cell differentiation (e.g., involucrin) may help predict the risk of malignancy, as their functions are dysregulated during carcinogenesis. 7,8 E-cadherin is a glycoprotein that mediates cell-cell adhesion and that has been investigated in oral carcinogenesis. Some studies have indicated a reduction in the immunohistochemical expression of this molecule in early stages and during the progression of oral cancer.…”

Section: Introductionmentioning

confidence: 99%

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Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study

et al. 2017

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To assess the immunocytochemical and immunohistochemical correlation of adhesion (E-cadherin) and cell differentiation (involucrin) molecules in oral leukoplakia and oral squamous cell carcinoma. Cytological samples and biopsies were obtained from male and female patients aged over 30 years with oral leukoplakia (n = 30) and oral squamous cell carcinoma (n = 22). Cell scrapings and the biopsy were performed at the site of the lesion and histological slides were prepared for the immunocytochemical analysis of exfoliated oral mucosal cells and for the immunohistochemical analysis of biopsy tissues using E-cadherin and involucrin. Spearman's correlation and kappa coefficients were used to assess the correlation and level of agreement between the techniques. Immunostaining for E-cadherin and involucrin by both techniques was similar in the superficial layers of the histological sections compared with cell scrapings. However, there was no statistical correlation and agreement regarding the immunocytochemical and immunohistochemical expression of E-cadherin and involucrin in oral leukoplakia (R = 0.01, p = 0.958) (Kappa = 0.017, p = 0.92) or in oral squamous cell carcinoma (R = 0.26, p = 0.206) (Kappa = 0.36, p = 0.07). The immunoexpression of E-cadherin and involucrin in tissues is consistent with the expression patterns observed in exfoliated oral mucosal cells, despite the lack of a statistically significant correlation. There is an association of the histopathological characteristics of leukoplakia with the expression E-cadherin and of the microscopic aspects of oral squamous cell carcinoma with immunohistochemical expression of involucrin.

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Section: Resultssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study

et al. 2017

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“…Cadherin‐1 (E‐cadherin) is expressed in epithelial cells and is an important cell adhesion molecule. It plays a role in cell growth, differentiation, migration and polarity . Loss of E‐cadherin is a hallmark of EMT …”

Section: Introductionmentioning

confidence: 99%

Alterations in the expression of EMT‐related proteins claudin‐1, claudin‐4 and claudin‐7, E‐cadherin, TWIST1 and ZEB1 in oral lichen planus

Hämäläinen

Soini

Pasonen‐Seppänen

et al. 2019

J Oral Pathology Medicine

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Background Oral lichen planus (OLP) is a chronic T‐cell‐mediated inflammatory disease, which is associated with increased risk of developing oral squamous cell carcinoma. Epithelial‐to‐mesenchymal transition is a physiological phenomenon occurring during growth and organogenesis, but it has also an important role in tumorigenesis. In the present work, we studied the expression of known epithelial‐to‐mesenchymal transition markers in oral lichen planus. Methods In total, 54 oral lichen planus and 22 control samples were analyzed for epithelial‐to‐mesenchymal transition markers. Samples were immunohistochemically stained for claudin‐1, claudin‐4 and claudin‐7, cadherin‐1 (E‐cadherin), Twist‐related protein 1 (TWIST1) and zinc finger E‐box‐binding homeobox 1 (ZEB1). Results The expression of claudin‐1, claudin‐4 and E‐cadherin was significantly weaker in oral lichen planus epithelium compared to controls (P < 0.001). The quantity of claudin‐7‐expressing cells (P < 0.001) and claudin‐7 staining intensity (P < 0.05) in the stroma was greater in lichen planus than in control samples. TWIST1 and ZEB1 stainings were negative in the epithelium in both lichen planus and controls. The number of TWIST1‐expressing cells in the stroma was higher in lichen planus than in controls (P < 0.001). There was a statistically significant difference in ZEB1 staining intensity in the stroma between lichen planus and control samples (P < 0.05). Conclusions The data indicate that the expression of claudin‐1, claudin‐4 and E‐cadherin is decreased in oral lichen planus. This may lead to disturbance in epithelial tight junctions, cell‐cell connections and epithelial permeability, contributing to oral lichen planus pathogenesis. Based on the present study, the role of TWIST1 and ZEB1 in oral lichen planus remains unclear.

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“…A marcação de E-caderina na mucosa normal era forte e contínua, diferente do que foi observado nas células neoplásicas, onde a expressão era mais fraca e descontínua (Pereira et al, 2016;Sridevi et al, 2015). …”

Section: E-caderinaunclassified

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

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Expression of E-cadherin in normal oral mucosa, in oral precancerous lesions and in oral carcinomas

Cited by 41 publications

References 22 publications

Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study

Expression of E-cadherin and involucrin in leukoplakia and oral cancer: an immunocytochemical and immunohistochemical study

Alterations in the expression of EMT‐related proteins claudin‐1, claudin‐4 and claudin‐7, E‐cadherin, TWIST1 and ZEB1 in oral lichen planus

Estudo comparativo dos aspectos clínicos, morfológicos e moleculares da ceratose actínica e do carcinoma de células escamosas na pele da região ventral abdominal de caninos domésticos

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