2000
DOI: 10.1016/s0022-5347(05)67322-3
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Expression of E-, P-, N-Cadherins and Catenins in Human Bladder Carcinoma Cell Lines

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Cited by 40 publications
(5 citation statements)
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“…Mialhe et al [17] observed that T24 cells were poorly differentiated but had yet a typical epithelial morphology. T24 cells possessed an N-cadherin-dependent adhesivness.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mialhe et al [17] observed that T24 cells were poorly differentiated but had yet a typical epithelial morphology. T24 cells possessed an N-cadherin-dependent adhesivness.…”
Section: Discussionmentioning
confidence: 99%
“…In various cancers [18-20]), including bladder cancer reduced E-cadherin expression has been shown to correlate with progression of disease. Mialhe et al [17] hypothesized that, N-cadherin expressed in T24 bladder cell, a highly invasive tumor, could play a major role in acquisition of invasive phenotype. Thus, it is not surprising, that bladder cancer cell line which we examined did not express E-cadherin molecules.…”
Section: Discussionmentioning
confidence: 99%
“…With such a large difference in UBC outcomes between early-stage disease (stage Ta) versus MIBC (stages T2þ), it is reasonable to assume that cell adhesion molecules, and in particular cadherins, play a fundamental role in the spread of bladder tumours, initially from the urothelium into the lamina propria (through the basement membrane) and subsequently into the detrusor muscle [22]. Therefore, the classical cadherins and their related molecular pathways represent attractive therapeutic targets for the inhibition of progression in bladder cancer patients [19,[58][59][60].…”
Section: Cadherinsmentioning
confidence: 99%
“…The softening of the neoplastic cells has already been reported in breast and bladder cancer models [ 80 , 81 , 82 , 83 ]. It was reported that RT112 cells possess both mesenchymal and epithelial phenotypes as they are an intermediate cell line for those states [ 11 , 84 ]. In our case, this correlates with the intermediate YM values observed for these cells compared to RT4 and T24.…”
Section: Resultsmentioning
confidence: 99%