Expression of EGF, EGFR and PCNA in laryngeal lesions

Wen, Qing‐Hua; Nishimura, Toshiro; Miwa, Takaki; Nagayama, Ikuo; Furukawa, Mitsuru

doi:10.1017/s0022215100130889

Cited by 13 publications

(4 citation statements)

References 28 publications

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“…The range of positive EGFR staining in head and neck squamous cell carcinoma has been reported from 55% to 100% 18–22 . In the present study, a high positive rate of EGFR staining was found in head and neck squamous cell carcinoma cases from the Asia–Pacific region, with 57% of strong staining or over‐expression of EGFR, which is similar to other studies reported as over‐expression in 42–80% of the cases 19,23 . A stronger EGFR staining was also observed with high extent of EGFR expression in head and neck squamous cell carcinoma in this study.…”

Section: Discussionsupporting

confidence: 89%

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia–Pacific region

Putti¹,

To²,

Hsu³

et al. 2002

Histopathology

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Section: Discussionsupporting

confidence: 89%

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia–Pacific region

Putti¹,

To²,

Hsu³

et al. 2002

Histopathology

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“…The PCNA expression was significantly less for benign lesions than for malignant epithelium, in accordance with the findings of Shin et al (1993) and Wen et al (1995). This suggests that PCNA expression may be of value for differentiating benign from malignant squamous epithelial lesions.…”

Section: Discussionsupporting

confidence: 85%

Proliferating cell nuclear antigen in laryngeal cancer

Kręcicki

Jeleń

1998

J. Laryngol. Otol.

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The expression of proliferating cell nuclear antigen in paraffin sections from 154 cases of laryngeal squamous cell carcinoma were examined. There was significant difference in PCNA expression between the control group and cancer patients (p<0.001). The mean score of PCNA was higher in patients with poor prognosis than in patients with satisfactory outcome after treatment (p<0.05). There was no significant correlation between the PCNA count and the patient's age and sex, T and N stage and site of the tumour.Univariate analysis revealed that the PCNA score correlated with the patients' survival rates. In multivariate analysis the prognostic value of PCNA was on the statistical borderline (p = 0.049). In our study clinical features like N and T status had a more important influence on survival rate. Nevertheless it appears that the immunohistological examination of PCNA in paraffin section could be a complementary prognostic tool for laryngeal carcinoma. PCNA expression may also be a valuable tool for differentiating malignant from benign laryngeal epithelium.

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“…Regards with this study, a high expression of EGFR staining was found in 101(67.3%) head and neck tumours (Table 3). This is in accordance with a study, which reported high expression of EGFR in 42-80% of the cases [5]. From this present study, high expression of EGFR was seen among both malignant and benign tumour of patients with head and neck (Table 3).…”

Section: Discussionsupporting

confidence: 93%

Prognostic Significance of Epidermal Growth Factor Receptor (Egfr) in Head and Neck Tumours at Some Selected Hospital in Ghana

Barnes

Yeboah

Zhu

et al. 2019

Preprint

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Background: Head and neck Tumour (HNT) are tumour of the paranasal sinuses, the salivary glands and the upper aero¬digestive tract. EGF can stimulate cell proliferation, cell differentiation, cell growth, migration, and inhibit apoptosis. The aim of this study was to investigate the expression of EGFR in head and neck tumour. Method: EGFR expression was analyzed using quantitative real-time PCR (qRT-PCR) and immunohistochemical staining on tissue samples from a consecutive series of 150 head and neck tumour patients who underwent tumor resections between 2014 and 2018. Results: The relationship between EGFR expressions, clinicopathological factors, was investigated. qRT-PCR results showed that the EGFR expression was high in tumor tissue samples than in the normal head and neck tissues. High and low EGFR was compared with ages ≤40,>40 in the head and neck cancer of p- value 0.03. There was a significant difference between the histological differentiation of the malignant tumour with p values of 0.001, when well, moderate and poor was compared. There was a significant difference (p-value 0.012) between the I-II and III-IV tumour stages when the high level and low expression of EGFR were compared. Conclusion: Our data suggest that EGFR plays an important role in head and neck tumour progression and that its expression will provide baseline data to facilitate identification of new molecular targeting therapeutics. Keywords: EGFR, Head and neck tumour, Clinicopathological factors.

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Expression of EGF, EGFR and PCNA in laryngeal lesions

Cited by 13 publications

References 28 publications

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia–Pacific region

Expression of epidermal growth factor receptor in head and neck cancers correlates with clinical progression: a multicentre immunohistochemical study in the Asia–Pacific region

Proliferating cell nuclear antigen in laryngeal cancer

Prognostic Significance of Epidermal Growth Factor Receptor (Egfr) in Head and Neck Tumours at Some Selected Hospital in Ghana

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