Expression of epstein-barr virus in patients with hodgkin's disease in taiwan

Liu, Shian-Min; Chow, Kuan‐Chih; Chiu, Chang-Fang; Tzeng, Cheng‐Hwai

doi:10.1002/(sici)1097-0142(19980715)83:2<367::aid-cncr22>3.0.co;2-q

Cited by 26 publications

(12 citation statements)

References 36 publications

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“…-Middle East (including Tunisia) [4][5][6][7][8][9][10][11][12]: between 28% of cases in a series from Jordan [12] and 70% of cases from Tunisia [4] were EBV-positive with HL; for Egypt [8], 50% were positive and 67% were of the NS type, which is similar to our findings -East Africa [13][14][15][16]: between 44% and 92% of cases were positive in Kenya -Central and South America [17][18][19][20][21][22][23]: between 31% of cases in Argentina [23] and 84% of cases in Peru [17] were positive -Asia [14,[24][25][26][27][28][29][30]: between 39% of cases in China [30] and 82% of cases in India [24] were positive, and the percentage of positive cases in most other countries was high (50% to 69%). For each country, the first column shows the number (n°) of cases studied whereas the other columns show the percentages of positive cases.…”

Section: Discussionsupporting

confidence: 80%

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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Fifty-five consecutive cases of Hodgkin's lymphoma (HL), collected between 1996 and 1998 from Cairo, Egypt, were histologically subtyped, phenotyped, and then studied for the presence of Epstein-Barr virus (EBV). We used immunohistochemical stains for EBV latent membrane protein 1 (LMP-1) and in situ hybridization stains for EBV-encoded small RNA (EBER-1) transcripts. Forty-five cases (82%) had classic HL (cHL), and ten cases (18%) had nodular lymphocyte predominant HL (NLPHL), with each group expressing its typical phenotype. LMP-1 stains were positive in 63% and 0% of cHL and NLPHL cases, respectively. EBER-positive Reed-Sternberg cells and variants were also present in 62% and 0% of each group, respectively. The cHL cases showed variable EBER positivity: nodular sclerosis, 58%; mixed cellularity, 100%; lymphocyte depletion, 100%; and unclassifiable, 67%. Our findings are similar to those from other developing countries and point towards a pathogenic role of EBV in cHL.

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Section: Discussionsupporting

confidence: 80%

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

et al. 2010

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“…Among the cases from NCKUH during the period 1996 through 2007, HL comprised 49 of the 636 (8%) malignant lymphoma cases diagnosed, which was similar to the 8% reported during 1982-1995, as detailed in the study by Liu et al in northern Taiwan. (15) Epstein-Barr virus in situ hybridization. Epstein-Barr virus-encoded early RNA was tested by in situ hybridization in all cases, and positivity was seen only in those tissue areas involving HL ( Fig.…”

Section: Resultsmentioning

confidence: 99%

“…A total of 173 cases of HL were studied, including 53 cases from the National Cheng Kung University Hospital (NCKUH), and 120 cases from the Veterans General Hospital (VGH)-Taipei, of which 70 cases have been published previously. (15) Studies were carried out under a laboratory protocol approved by the institutional review board. The cases from VGH-Taipei were submitted by using a high-density tissue array technique as described previously.…”

Section: Methodsmentioning

confidence: 99%

“…To study the changing patterns in the frequency of HL subtypes and EBV association over time, these cases were divided into two time periods: one was from 1982 to 1995 and the other was from 1996 to April 2007, based on a previous study. (15) The specimens were fixed in 10% neutral formalin solution. All of the cases were reviewed and classified by two hematopathologists according to the World Health Organization (WHO) classification criteria in May 2007.…”

Section: Methodsmentioning

confidence: 99%

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Changing patterns in the frequency of Hodgkin lymphoma subtypes and Epstein–Barr virus association in Taiwan

et al. 2008

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Epstein-Barr virus (EBV) infection is a risk factor for Hodgkin lymphoma (HL).To test whether the frequency of HL subtypes and their association with EBV has shifted with rising socioeconomic status in Taiwan, we compared the pathological features and EBV status, detected by in situ hybridization, of HL diagnosed between 1996 and 2007 (99 cases) and 1982 and 1995 (74 cases). The male-tofemale ratio was 121:52 (2.3:1) and the mean age at presentation was 41.5 years. The overall EBV positivity rate was 50% (86/173 cases). Comparing the distribution of HL cases diagnosed at two different time periods, we found an increased frequency of the nodular sclerosis (NS) subtype (53 vs 68%, P = 0.045), a decreased frequency of the mixed cellularity subtype (35 vs 13%, P < 0.001), a reduced male-to-female ratio (2.9:1 compared to 1.4:1) and mean age (42.4 vs 36.6 years) in the NS subtype, and a significant decrease in EBV positivity rates among the NS and lymphocyte-depletion subtypes (61 vs 39%, P = 0.03). These data indicate shifts in the frequency of histological subtype and EBV association for HL in Taiwan (1) Previous studies have demonstrated that acute EBV infection (or infectious mononucleosis) is a risk factor for Hodgkin lymphoma (HL), (2,3) and its infectious manifestations, especially age at infection, are affected by socioeconomic status. (4,5) Among the five subtypes of HL, nodular lymphocyte predominance (NLP), nodular sclerosis (NS), mixed cellularity (MC), lymphocyte-rich classical (LRC), and lymphocyte depletion (LD), the MC subtype is most frequently associated with EBV worldwide, ranging from 72 to 86%, whereas the NLP subtype is almost always EBV negative in Western countries.(6-8) However, we and others have previously found that EBV is associated with all histological subtypes of HL in Vietnamese and southern American children, especially the NLP subtype, which showed a 100% positivity rate. (6,9,10) The differences in EBV association between HL in developed and developing countries and with different histological subtypes may be reconciled by the 'two-disease hypothesis', which proposes that the HL seen in the younger group is infectious in nature whereas that in older persons has causes similar to other types of lymphomas. (11,12) Epidemiological studies have revealed three patterns of HL distribution. Pattern 1, seen in developing countries and in patients of low socioeconomic status, shows an early childhood peak with tumors that are predominantly MC subtype and EBV positive. Pattern 3, seen in developed countries and in patients of high socioeconomic status, shows a peak incidence in the third decade with tumors that are mainly NS subtype and EBV negative. Pattern 2, seen in countries with transitional economies, has an early childhood peak and a second decade peak with an equal frequency of the MC and NS subtypes. (2,13,14) It is therefore intriguing to observe whether there exists a change in the frequency of HL subtypes and EBV association with time in countries like Taiwan, where socioeconomi...

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“…In common with other studies, the EBV-positive rate was higher in males. 21,30 Comparison of the variation in the EBV-positive rate with age between different studies is difficult due to the use of different age band categories, and the histological subtypes that are included in the analysis.…”

Section: Agementioning

confidence: 99%

Variation in the frequency of Epstein–Barr virus-associated Hodgkin's disease with age

et al. 2000

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A number of studies in developed countries have reported variation in the frequency of Epstein-Barr virus (EBV)-associated Hodgkin's disease (HD) with age. A 'three disease' model for HD that incorporates the EBV association, histological subtype of HD and age has recently been proposed. In this model, Hodgkin's disease of childhood and older adults is commonly EBV-associated and of mixed cellularity type, whereas young adult HD is generally not EBV-associated and is usually characterised by nodular sclerosis disease. A case series of HD diagnosed in the West Midlands between 1981 and 1997, inclusive, was used to investigate the applicability of the 'three disease' model. In situ hybridisation for the EBV early RNAs (EBERs) was used to determine the presence of EBV in the malignant Hodgkin/Reed-Sternberg cells. In contrast to the 'three disease' model, nodular sclerosis was the predominant subtype in each of the age groups within the case series. In addition, overall there was little variation in EBV-positive rates across the age ranges examined. However, when females were analysed separately, older women (45؉ years) were significantly more likely to have EBV-positive disease than their younger counterparts (Ͻ45 years). In summary our results do not generally support the 'three disease' model. Leukemia (2000) 14, 748-753.

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Expression of epstein-barr virus in patients with hodgkin's disease in taiwan

Cited by 26 publications

References 36 publications

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

Epstein–Barr virus and Hodgkin’s lymphoma in Cairo, Egypt

Changing patterns in the frequency of Hodgkin lymphoma subtypes and Epstein–Barr virus association in Taiwan

Variation in the frequency of Epstein–Barr virus-associated Hodgkin's disease with age

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