Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

Zhu, Guochen; Xiao, Dajiang; Sun, Ping

doi:10.3892/ol.2016.4230

Cited by 16 publications

(10 citation statements)

References 41 publications

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“…Since recent data indicate that ER and PR may be expressed by the smooth muscle cells in sinonasal-ALM, 3 immunohistochemical stains were performed for both receptors, but the result was negative. In addition, since in particular in the context of immunodeficiency smooth muscle tumor may be related to Epstein Barr Virus (EBV) infection, 4 EBER in situ hybridization was performed on both tumors, but the result was negative.…”

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confidence: 99%

Sinonasal Angioleiomyoma With Adipocyte Differentiation: Clinicopathologic Study of 2 Cases and Review of the Literature

et al. 2019

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Two patients presented to the otolaryngology department of our university with a history of left nasal obstruction. The first case, a 50-year-old man, presented with a 3-month progressively worsening history of left maxillary swelling with mild facial pain and left nasal obstruction. A previous diagnosis of AIDS was reported; tuberous sclerosis was excluded by clinical workup. No alcohol consumption or smoking was reported. Nasal endoscopy revealed the presence of a reddish mass in the middle meatus, arising from the left inferior turbinate (Figure 1A). Narrow band imaging evaluation showed a relatively regular arrangement of intraepithelial capillary; the microvascular network and submucosal veins are nearly invisible (Figure 1B). The patient underwent a maxillofacial computed tomography (CT) scan with contrast that confirmed the presence of a soft density tissue of 13 mm in diameter, occupying the posterior portion of the middle turbinate, without evidence of bony erosion in the medial wall ( Figure 1C). The patient underwent an endoscopic resection of the mass. No signs of recurrence of the disease were observed 1 year after surgery.The second case, a 63-year-old male, presented with left-side nasal obstruction and rhinorrhea. Anterior rhinoscopy revealed in the left nasal fossa a smooth spherical nasal mass arising from the head of the left inferior turbinate, without bleeding on touch. Contrast-enhanced CT scan showed a soft density tissue, arising from the head of the left inferior turbinate, without evidence of bony erosion (Figure 2). These clinical features were suggestive of a benign tumor; thus, a complete excision with nasal endoscopy was performed. No signs of recurrence of the disease were observed 5 months after surgery.Both excised tumors consisted of vascular channels surrounded by thick muscular coats associated with intersecting fascicles of spindle cells. Cavernous-like vessels were also recognized in case 1 and aggregates of lymphocytes in case 2. Of note, mature adipocytes were identified in both tumors. While in case 1 they formed large aggregates, in case 2 they were distributed either singularly or in very small clusters. In both tumors, mitosis, pleomorphism, and necrosis were absent, and immunohistochemical analysis performed as described previously 1 demonstrated positivity of the spindle cells for smooth muscle actin and musclespecific actin and negativity for S100, HMB45, MelanA, estrogen receptor (ER) and progesterone receptor (PR); the proliferative activity (Ki67) was less than 3%, and Epstein-Barr Encoding Region (EBER) in situ hybridization was negative (Figure 3). Based on these findings, the pathologic diagnosis of sinonasal-ALM with adipocytic differentiation 2 was made.The occurrence of mature adipocytes in an otherwise typical sinonasal-ALM is not uncommon. Indeed, the term angiomyolipoma has been inappropriately used to describe typical sinonasal-ALM. However, angiomyolipoma is a completely different entity, since lesional cells co-express melanocytic (mainly HMB45) and my...

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confidence: 99%

Sinonasal Angioleiomyoma With Adipocyte Differentiation: Clinicopathologic Study of 2 Cases and Review of the Literature

et al. 2019

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“…Second, these tumors may arise from vascular smooth muscle cells, but there is limited published immunohistochemical evidence to confirm whether vascular leiomyomas/angioleiomyomas frequently express ER and PgR, which are seen in leiomyomas of the deep soft tissue. [ 30 – 32 ] Third, de novo leiomyomas arising from abdominal wall surgical scars have been reported, [ 1 , 2 ] but an incisional scar was absent in our case. Fourth, the rectus sheath may be the origin of anterolateral wall leiomyomas, [ 6 , 10 ] but the present tumor was removed easily from the rectus sheath, making this unlikely.…”

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confidence: 63%

Multilocular cystic leiomyoma of the anterolateral abdominal wall

Yorita¹,

Tanaka²,

Hirano³

et al. 2017

Medicine

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Rationale:Leiomyomas arising from the anterolateral abdominal wall are uncommon, and their pathogenesis remains unknown. We present the 15th case of such a tumor, having this unique tumor morphology, followed by a detailed discussion on disease pathogenesis.Patient concerns:A 48-year-old, asymptomatic perimenopausal, multiparous Japanese woman presented with a left-sided pelvic mass. She had no history of previous surgeries or uterine leiomyomas. Although a transabdominal ultrasonogram raised suspicions of an ovarian tumor, a transvaginal ultrasonogram confirmed normal ovaries. Radiological images showed a multilocular cystic mass with enhanced solid lesions connected to the uterus. Retrospective radiological evaluation showed that the mass was largely connected to the peritoneum of the anterolateral abdominal wall.Interventions:Intraoperatively, the mass appeared as a dome-like protrusion from the left lower quadrant of the abdominal wall, without connection to the uterus, ovaries, or the left round ligament. No other peritoneal masses were seen. The mass was easily enucleated from the abdominal wall. Pathology confirmed that the mass was a leiomyoma with hydropic and myxoid degeneration. No striated muscle tissues were noted between the tumor and resection margin, but a thin smooth muscle layer, positive for hormone receptors, was present at the periphery, suggesting the origin of the tumor.Lessons:Benign leiomyomas of the anterolateral abdominal wall likely originate from Müllerian-like smooth muscle remnants in this region. They should be considered in the differential diagnosis of solid and cystic masses and be distinguished from uterine and ovarian masses on imaging to avoid unnecessary organ resection.

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“…Los AL pueden expresar receptores de estrógenos y de progesterona determinados por IHQ 33 , como se observó en la presente serie.…”

Section: Discussionunclassified

“…Es habitual encontrar pleomorfismo celular, como observamos en nuestra serie. Se han descrito casos con receptores androgénicos positivos 4 , 11 , 33 .…”

Section: Discussionunclassified

Cutaneous leiomyomas: a clinicpathological and epidemiological review

2021

An Sist Sanit Navar

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Fundamento. Los leiomiomas cutáneos, superficiales o suprafasciales, se dividen en tres variantes: piloleiomiomas (PL), angioleiomiomas (AL) y leiomiomas genitales (LG) que incluyen las formas vulvares, escrotales y areolares. El objetivo fue establecer las características clinicohistológicas y la incidencia de cada variante, y las posibles asociaciones con neoplasias internas. Material y métodos.Se revisaron 255 casos de leiomiomas cutáneos diagnosticados entre 1982 y 2018 en los servicios de Anatomía Patológica de tres centros hospitalarios (Navarra y Alicante). Se describieron y compararon variables demográficas, clínicas, histológicas e inmunohistoquímicas.Resultados. La incidencia en Navarra de PL fue 4,3 casos por año y millón de habitantes, de AL 20 y de LG 1,4. Las formas cutáneas suponen aproximadamente el 3,5 % del total de leiomiomas. La población con PL sufrió más frecuentemente cáncer de mama (OR = 4,8; IC95%: 1,3-17,4; p = 0,006). Los leiomiomas areolares son de pequeño tamaño, acompañados de dolor local, predominantemente fasciculares o sólidos, con muy rara afectación del tejido celular subcutáneo y escasa atipia. Esto contrasta con el resto de LG, de tamaño medio y rara vez dolorosos, predominantemente nodulares, con frecuente afectación del tejido celular subcutáneo y atipia. Conclusiones.Se aporta información sobre las características clinicohistológicas de las distintas variantes de leiomiomas, según las cuales debería replantearse la clasificación de los leiomiomas areolares fuera del grupo de LG. Se detectó una asociación entre PL y carcinoma de mama que deberá confirmarse en futuros estudios para determinar si este leiomioma constituye un marcador de riesgo de cáncer de mama en mujeres.

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Expression of estrogen and progesterone receptors in angioleiomyoma of the nasal cavity of six patients

Cited by 16 publications

References 41 publications

Sinonasal Angioleiomyoma With Adipocyte Differentiation: Clinicopathologic Study of 2 Cases and Review of the Literature

Sinonasal Angioleiomyoma With Adipocyte Differentiation: Clinicopathologic Study of 2 Cases and Review of the Literature

Multilocular cystic leiomyoma of the anterolateral abdominal wall

Cutaneous leiomyomas: a clinicpathological and epidemiological review

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