Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables

Rath‐Wolfson, Lea; Purim, Ofer; Ram, Edward; Morgenstern, Sara; Koren, Rumelia; Brenner, Baruch

doi:10.3892/or.2012.1712

Cited by 7 publications

(10 citation statements)

References 11 publications

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“…Sex steroids, such as estrogen, are well-known for their role(s) in the control of cell differentiation and proliferation in estrogen-dependent tissues such as breast and endometrial tissues. However, it is noteworthy that estrogens appear to play a pivotal role in several types of human malignancies that are not considered as classical, estrogen-dependent, neoplasms, such as lung (6,7), urinary bladder (8) and gastrointestinal tract malignancies (9,10). Consequently, estrogenic pathways may be involved in the regulation of the biological behavior of ESCC.…”

Section: Introductionmentioning

confidence: 97%

Expression of estrogen receptor α and β in esophageal squamous cell carcinoma

et al. 2013

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Estrogen receptors (ERs) are frequently expressed in human tumor tissues. There have been several studies concerning ER expression in esophageal cancers, yet the results are inconsistent, and the prognostic value of the receptors remains unclear. In the present study, we investigated the expression of ER protein and its correlation with clinical features of esophageal squamous cell carcinoma (ESCC) patients. Immunohistochemical staining for the ERs was carried out on paraffin-embedded primary tumor tissue sections from 89 patients with ESCC. Quantitative analyses were performed to determine the prognostic value of the expression of ERs, and Pearson's correlation was used to examine the relationship between ERα and ERβ expression levels. Our results showed that ERα immunoreactivity was significantly lower in ESCC than that in the non-neoplastic epithelium (P=0.0445), whereas the ERβ status was much stronger in ESCC than that in the non-neoplastic epithelium (P=0.0243). A significant inverse correlation was observed between ERα expression and depth of tumor invasion (P=0.0426). Correlation analysis revealed a statistically significant inverse correlation between the expression of ERα and ERβ in ESCC (r=-0.2902, P=0.0058). Kaplan-Meier survival analysis showed that the patients with ERα expression (21/89) had a better outcome than patients without ERα expression (P=0.0280), whereas patients with high ERβ immunoreactivity (44/89) were significantly associated with worse survival (P=0.0366). In conclusion, ERα and ERβ levels were inversely correlated, and the downregulation of ERα and upregulation of ERβ may indicate unfavorable prognosis of ESCC.

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Section: Introductionmentioning

confidence: 97%

Expression of estrogen receptor α and β in esophageal squamous cell carcinoma

et al. 2013

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“…reported that the expression of ER alpha was negative in all cases of colorectal cancer similar to the present study. 31 Studies from Waliszewski et al . uncovered that ER alpha was not expressed in the isolated colorectal cancer cells and cell lines.…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor beta expression in colitis‐associated carcinoma in comparison with sporadic colonic tumor: An immunohistochemical study

et al. 2023

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Background and Aim The rate of ulcerative colitis (UC)‐related colorectal cancer (colitis‐associated carcinoma) is increasing. Estrogen receptor (ER) beta expression has been studied separately in patients with sporadic colorectal cancer and those with colitis‐associated carcinoma. However, no study has compared the expression in both of these cancer types. The present study aimed to evaluate the relationship between colitis‐associated carcinoma and ERs and assess whether the expression of ER beta influences cell proliferation. Methods This study included 45 surgically operated colitis‐associated carcinomas, 43 high‐grade dysplasias, 34 low‐grade dysplasias, 36 sporadic colorectal cancers, 44 high‐grade adenomas, and 34 low‐grade adenomas. ER beta expression was evaluated with immunohistochemistry. Results Colitis‐associated carcinoma showed significantly lower ER beta immunoexpression than sporadic colorectal lesions and high‐ and low‐grade dysplasia. In seven colitis‐associated carcinoma harboring both intensity score 3 (strong immunoexpression) and score 1 (weak immunoexpression) areas, the correlation among ER beta intensity, Ki‐67, and p21 labeling index was assessed; an area with an ER beta intensity score of 3 showed a higher Ki‐67 labeling index than that with score 1. In four out of the seven lesions, p21 labeling index was higher in the area of ER beta score 1 than in that of ER beta score 3. Conclusions The data suggest that ER beta expression is an accelerating factor in colorectal tumors. This association may be lower in colitis‐associated carcinoma than in sporadic colorectal cancer.

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“…The intensity was rated 0-3 (0, for no nuclear stain; 1, for the weakest nuclear stain; and 3, for the strongest nuclear stain) in comparison with the control stain. A score was calculated by multiplying the intensity of each field with the percentage of positively stained cells and then by a factor of 100 (i.e., if 20% of the nuclei in the slide was stained with an intensity of 2 the slide got a score of 40) (25). The mean score of five fields was named 'Topo II-α index' of the specimen.…”

Section: Expression Of Topoisomerase Ii-α Protein In Salivary Gland Tmentioning

confidence: 99%

Expression of Topoisomerase II‑α protein in salivary gland tumors

et al. 2017

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Salivary glands give rise to approximately 30 histological distinct tumor types, which results in a diagnostic challenge for the pathologist. The present retrospective, immunohistochemical study aimed to evaluate the expression of Topoisomerase II-α, a nuclear enzyme, as a diagnostic and prognostic marker in benign and malignant salivary gland tumors, including leomorphic adenoma, mucoepidermoid carcinoma, acinic cell carcinoma and carcinoma ex-pleomorphic adenoma. A total of 59 cases of benign and malignant salivary gland tumors were included in the present study. Representative paraffin-embedded sections were immunostained for Topoisomerase II-α (Topo II-α). The expression level was semi-quantified for each case and then correlated with the histological diagnosis using hematoxylin and eosin-stained slides, grade of tumor and total survival. Significant differences were revealed between the expression level of Topo II-α in pleomorphic adenoma and mucoepidermoid carcinoma (P<0.001), carcinoma ex-pleomorphic adenoma (P<0.001), acinic cell carcinoma (P=0.005) and a group composed of all the malignant tumors (P<0.001). Cancer-specific survival rates were insignificantly increased in tumors expressing low levels of Topo II-α (P=0.464). Thus, the present study demonstrated different expression levels of Topo II-α in benign and malignant salivary gland tumors. These differing expression levels may act as valuable biomarkers for the correct histological diagnosis. Further studies conducted on a larger scale may lead to even more conclusive results.

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Expression of estrogen receptor β1 in colorectal cancer: Correlation with clinicopathological variables

Cited by 7 publications

References 11 publications

Expression of estrogen receptor α and β in esophageal squamous cell carcinoma

Expression of estrogen receptor α and β in esophageal squamous cell carcinoma

Estrogen receptor beta expression in colitis‐associated carcinoma in comparison with sporadic colonic tumor: An immunohistochemical study

Expression of Topoisomerase II‑α protein in salivary gland tumors

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