Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse

Kurose, Hitomi; Bito, Takaaki; Adachi, Taro; Shimizu, Motohiro; Noji, Sumihare; Ohuchi, Hideyo

doi:10.1016/j.modgep.2004.04.005

Cited by 67 publications

(87 citation statements)

References 24 publications

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“…In HH14 chick embryos, the Fgf19 expression domain was maintained in the epibranchial placodes and mesoderm around the otic vesicle ( Fig. 1B; Kurose et al, 2004;Sanchez-Calderon et al, 2006). A weak Fgf19 expression was also observed both in the optic stalk and optic vesicle and was maintained until at least HH26 (Figs.…”

Section: Fgf15 Expression Patterns In the Neural Tubementioning

confidence: 90%

“…Other Fgf conserved clusters have been described (Ornitz and Itoh, 2001;Katoh, 2002), and in most cases, these clusters have been functionally related to carcinogenic processes (Katoh, 2002). From a developmental and functional perspective, both Fgf19 and Fgf15 have been related with otic embryonic induction (Graham, 2000;Ladher et al, 2000;Wright et al, 2004) and eye development (Kurose et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

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Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh

Gimeno

Martı́nez

2007

Developmental Dynamics

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Fibroblast growth factors (Fgfs) constitute a family of signaling molecules that play essential roles in development. We have studied the expression pattern of mouse Fgf15 in the developing brain. Fgf19 is another member of the FGF family that has been suggested as the chick and human ortholog of mouse and rat Fgf15. Here, we compare the expression pattern during neural development of chick Fgf19 with mouse Fgf15. Unlike Fgf15, Fgf19 presents an expression in the isthmic alar plate, diencephalic and mesencephalic parabasal plates, hindbrain basal plate, as well as in the zona limitans intrathalamica (zli). Moreover, we explored the regulation between Fgf19 and the signaling molecules of the isthmic and zli organizers: Fgf8 and Shh, respectively. Considering the possibility that Fgf19 plays a similar role in humans and chicks, this finding could explain the significant diencephalic phenotypic differences between humans and mice in models and diseases where the Shh pathway is affected. Developmental Dynamics 236:2285-2297, 2007.

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Section: Fgf15 Expression Patterns In the Neural Tubementioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh

Gimeno

Martı́nez

2007

Developmental Dynamics

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“…Notably, 2 amacrine cells expressed Fgf15, a marker of retinal progenitor cells. Kurose et al have reported expression of Fgf15 in a subset of amacrine cells, suggesting that this expression represents normal amacrine cell type-specific expression (26).…”

Section: Distinct Morphological Types Of Amacrine Cell Are Labeled Bymentioning

confidence: 99%

Development and diversification of retinal amacrine interneurons at single cell resolution

Cherry

Trimarchi

Stadler

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

115

147

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The vertebrate retina uses diverse neuronal cell types arrayed into complex neural circuits to extract, process, and relay information from the visual scene to the higher order processing centers of the brain. Amacrine cells, a class of interneurons, are thought to mediate much of the processing of the visual signal that occurs within the retina. Although amacrine cells display extensive morphological diversity, the molecular nature of this diversity is largely unknown. Furthermore, it is not known how this diversity arises during development. Here, we have combined in vivo genetic labeling, single cell genome-wide expression profiling, and classical birthdating to (i) identify specific molecular types of amacrine cells, (ii) demonstrate the molecular diversity of the amacrine cell class, and (iii) show that amacrine cell diversity arises at least in part through temporal patterning.amacrine cell ͉ neuronal classification ͉ retinal development ͉ single cell profiling ͉ molecular taxonomy

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“…In contrast, the expression of Fgf4, 9, and 17 is restricted to the central-posterior portion of the AER and only during the intermediate stages of AER development (Martin, 1998). Two other Fgfs, Fgf2 and Fgf19, have also been shown to be expressed in the chick AER (Savage et al, 1993;Dono and Zeller, 1994;Kurose et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP‐mediated cell death

Delgado

Domínguez-Frutos

Schimmang

et al. 2008

Developmental Dynamics

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Here we analyze limb development after the conditional inactivation of Fgf8 from the epiblast, using the previously described MORE (Mox2Cre) line. This line drives variable mosaic recombination of a floxed Fgf8 allele, resulting in a small proportion of AER cells that maintain Fgf8 expression. The phenotype of Mox2Cre;Fgf8 limbs is most similar to that of Msx2Cre;Fgf8 forelimbs, indicating that a small but durable expression of FGF8 is equivalent to an early normal, but transitory, expression. This functional equivalence likely relies on the subsequent Fgf4 upregulation that buffers the differences in the pattern of Fgf8 expression between the two conditional mutants. The molecular analysis of Mox2Cre;Fgf8 limbs shows that, despite Fgf4 upregulation, they develop under reduced FGF signaling. These limbs also exhibit an abnormal area of cell death at the anterior forelimb autopod, overlapping with an ectopic domain of Bmp7 expression, which can explain the abnormal morphogenesis of the anterior autopod. Developmental Dynamics 237: 649 -658, 2008.

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Expression of Fibroblast growth factor 19 (Fgf19) during chicken embryogenesis and eye development, compared with Fgf15 expression in the mouse

Cited by 67 publications

References 24 publications

Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh

Expression of chick Fgf19 and mouse Fgf15 orthologs is regulated in the developing brain by Fgf8 and Shh

Development and diversification of retinal amacrine interneurons at single cell resolution

The incomplete inactivation of Fgf8 in the limb ectoderm affects the morphogenesis of the anterior autopod through BMP‐mediated cell death

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