Expression of fibroblast growth factor receptors in naevus-cell naevus and malignant melanoma

Ahmed, N. U.; Ueda, Mitsuharu; Itô, Akira; Ohashi, Atsuko; Funasaka, Yoko; Ichihashi, M.

doi:10.1097/00008390-199708000-00004

Cited by 28 publications

(15 citation statements)

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“…Normal human melanocytes do not express bFGF (basic fibroblast growth factor, FGF‐2) 11, 12, whereas some naevi 13–15 and virtually all melanomas produce bFGF, with expression levels increasing with tumour progression 16–18. Recently, Gartside et al reported that 10% of melanoma tumours and cell lines harbour mutations in one of the receptors for bFGF, the FGF2 receptor 2 ( FGFR2 ) gene 19.…”

Section: Recent Novel Findings In Melanoma Researchmentioning

confidence: 99%

Recent progress in understanding the pathology of malignant melanoma

Kuphal

Bosserhoff

2009

The Journal of Pathology

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Recently, several important findings on melanoma development and progression have accelerated progress towards a molecular understanding of melanoma biology. Furthermore, the development of experimental tools, such as a wide range of cell lines and animal models of metastasis, has turned melanoma into a model for general tumour research. However, it has also become evident that melanoma is distinct from other tumours with regard to its cellular origin and pathophysiological mechanisms. This review focuses on important new findings that have contributed to a greater understanding of the molecular processes leading to melanoma. Translating these innovative new results into potent therapeutic approaches will require even more effort.

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Section: Recent Novel Findings In Melanoma Researchmentioning

confidence: 99%

Recent progress in understanding the pathology of malignant melanoma

Kuphal

Bosserhoff

2009

The Journal of Pathology

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“…Expression of mRNA for basic fibroblast growth factor (bFGF, FGF-2), a potent angiogenesis factor, has been detected in metastatic and primary invasive melanomas, whereas melanocytes in benign nevi did not express this factor (Reed et al, 1994) . Melanomas that were undergoing regression and dysplastic nevi cells were also observed to express bFGF mRNA, however, and bFGF expression levels were also found to be higher in benign melanocytic nevi than in malignant melanoma cells (Ahmed et al, 1997). It has even been reported that melanomas with bFGF-positive vessels had a better prognosis when compared with melanomas with bFGF-negative vessels (Straume and Akslen, 2002), suggesting that bFGF upregulation cannot be correlated with malignant transformation in human melanomas.…”

Section: Expression Of Angiogenesis Modulators By Human Melanomasmentioning

confidence: 99%

Angiogenesis, lymphangiogenesis, and melanoma metastasis

Streit¹,

2003

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The induction of angiogenesis is a critical point in the development of most human tumors -including melanomas. Some of the earliest studies in the field of tumor angiogenesis showed that transplantation of human melanoma fragments into the hamster cheek pouch stimulated blood vessel growth. Since then, numerous studies have demonstrated that human melanomas also induce angiogenesis. The prognostic importance of the degree of melanoma vascularization, however, has remained controversial. Elevated expression of several angiogenic factors, including vascular endothelial growth factor, basic fibroblast growth factor, and interleukin-8, has been detected in primary cutaneous melanomas, and the importance of these mediators in promoting melanoma angiogenesis and metastasis has been confirmed in tumor xenotransplant models. Based upon these findings, several clinical trials of angiogenesis inhibitors have been initiated in human melanoma patients and are currently underway. Recent experimental evidence indicates that tumorassociated lymphangiogenesis also plays an important role in mediating tumor spread to regional lymph nodes. These observations have important implications for prognosis and treatment of human melanomas.

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“…Expression of bFGF is upregulated in many human tumors including melanoma. Whereas normal human melanocytes do not express bFGF (Reed et al, 1994;Scott et al, 1991), some nevi express it (Ahmed et al, 1997;Mancianti et al, 1993;Ueda et al, 1994) and virtually all melanomas produce bFGF, with expression levels increasing during tumor progression (al-Alousi et al, 1996a,b;Albino et al, 1991). An autocrine growth stimulatory role for bFGF in melanoma has been clearly established through inhibition of bFGF activity by intracellular injection of blocking antibodies (Halaban et al, 1988) or by suppression of synthesis with antisense oligodeoxynucleotides (Becker et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

et al. 1999

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Basic ®broblast growth factor (bFGF or FGF-2) is produced by nearly all melanomas in vitro and in vivo but not by normal melanocytes, which require exogenous bFGF for growth. In this study, we transduced normal human melanocytes to overexpress two forms of bFGF: (bFGF-Long and bFGF-Short) using replication-de®cient adenovirus 5 vectors. bFGF-Long induced the 17.8, 22.5, 23.1 and 24.2 kDa forms of bFGF, whereas bFGF-Short induced only the 17.8 kDa mature form. Growth of cultured melanocytes transduced with either vector was similar to that of nevus and melanoma cells and was independent of exogenous bFGF and of insulin/insulinlike growth factor 1, and cyclic AMP enhancers, requiring only phorbol ester as an exogenous mitogen. Like primary melanoma cells, transduced normal melanocytes grew anchorage independently in soft agar. When injected into the dermis of human skin grafted to mice, bFGF-transduced melanocytes proliferated for at least 20 days, whereas cells from control cultures showed poor survival and no proliferation. These results demonstrate that bFGF upregulation is a critical component in melanoma progression.

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Expression of fibroblast growth factor receptors in naevus-cell naevus and malignant melanoma

Cited by 28 publications

References 0 publications

Recent progress in understanding the pathology of malignant melanoma

Recent progress in understanding the pathology of malignant melanoma

Angiogenesis, lymphangiogenesis, and melanoma metastasis

Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

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