Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin

Makino, Teruhiko; Mizawa, Megumi; Yamakoshi, Takako; Takaishi, Mikiro; Shimizu, Tadamichi

doi:10.1016/j.bbrc.2014.04.165

Cited by 34 publications

(37 citation statements)

References 18 publications

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“…Like FLG, FLG2 has an important role in skin barrier function. 6;8 Unlike FLG, FLG2 has not been as thoroughly studied. In our study we are able to demonstrate that FLG2 is variably expressed in the stratum corneum of dermatitic skin.…”

Section: Discussionmentioning

confidence: 99%

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Filaggrin‐2 barrier protein inversely varies with skin inflammation

Seykora

Dentchev

Margolis

2015

Experimental Dermatology

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Section: Discussionmentioning

confidence: 99%

“…7 The FLG2 gene is structurally similar to the FLG gene and the FLG2 protein is has similar biochemical and biophysical properties to the FLG protein. 8 Like FLG, the production of FLG2 protein has also been shown to be diminished in those with AD and in the presence of inflammatory mediators. 3;6 s1…”

Section: Introductionmentioning

confidence: 99%

Filaggrin‐2 barrier protein inversely varies with skin inflammation

Seykora

Dentchev

Margolis

2015

Experimental Dermatology

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“…have very recently found that the expression of filaggrin and filaggrin‐2 was markedly increased in patients with OLP and leucoplakia . In 2014, Makino et al . showed that filaggrin and filaggrin‐2 were increased in skin biopsies from patients with hyperkeratotic disease such as LP.…”

Section: Discussionmentioning

confidence: 99%

“…Filaggrin also functions as the major source of hygroscopic components, ‘the natural moisturizing factors’ . The expression of filaggrin has been examined in atopic skin disease and in hyperkeratotic skin disease showing a downregulation and an upregulation, respectively . As OLP is a hyperkeratotic mucosal disease and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in OLP lesions.…”

Section: Introductionmentioning

confidence: 99%

“…12 The expression of filaggrin has been examined in atopic skin disease and in hyperkeratotic skin disease showing a downregulation and an upregulation, respectively. 13,14 As OLP is a hyperkeratotic mucosal disease and filaggrin is essential to keratinization, the distribution of filaggrin may be altered in OLP lesions. As in the epidermis, filaggrin is formed from profilaggrin in keratohyalin granules in the stratum granulosum of orthokeratinized oral mucosa, particularly in the hard palate and parts of the gingiva.…”

Section: Introductionmentioning

confidence: 99%

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Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls

Larsen

Johansen

Reibel

et al. 2017

Acad Dermatol Venereol

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Effect of tumour necrotic factor‐α, interleukin‐17 and interleukin‐22 on the expression of filaggerin‐2 and hornerin: Analysis of a three‐dimensional psoriatic skin model

Makino,

Mizawa,

Takemoto

et al. 2024

Skin Health and Disease

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BackgroundFilaggrin‐2 (FLG2) and hornerin (HRNR) are members of the S100 fused‐type protein family, which share many properties with filaggrin (FLG). A previous study demonstrated that the expression of FLG2 was significantly decreased in psoriatic skin relative to that in normal skin. In contrast, the HRNR expression in psoriatic skin varied among studies.ObjectivesWe aimed to investigate the effect of tumour necrosis factor‐α (TNF‐α), IL‐17A and IL‐22 on the expression of FLG2 and HRNR using a three‐dimensional psoriatic skin model.MethodsIn the present study, we generated a 3D psoriatic skin model that was stimulated with TNF‐α, IL‐17A and IL‐22 for 3D skin equivalents. Using this model, we examined the altered expression of FLG2 and HRNR by quantitative reverse transcription polymerase chain reaction and immunostaining.ResultsIn the 3D psoriatic skin model, the expression of FLG2 and HRNR was significantly reduced compared with that in the 3D control skin. FLG2 expression was significantly decreased by stimulation with TNF‐α, IL‐17A and IL‐22. In contrast, the expression of HRNR was markedly increased by stimulation with IL‐22, although it was slightly decreased by TNF‐α or IL‐17A compared to the 3D control skin.ConclusionTNF‐α, IL‐17A and IL‐22 have different effects on FLG2 and HRNR expression and epidermal structure formation. Furthermore, FLG2 and HRNR may play different roles in barrier formation and the pathogenesis of psoriasis.

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Expression of filaggrin-2 protein in the epidermis of human skin diseases: A comparative analysis with filaggrin

Cited by 34 publications

References 18 publications

Filaggrin‐2 barrier protein inversely varies with skin inflammation

Filaggrin‐2 barrier protein inversely varies with skin inflammation

Filaggrin gene mutations and the distribution of filaggrin in oral mucosa of patients with oral lichen planus and healthy controls

Effect of tumour necrotic factor‐α, interleukin‐17 and interleukin‐22 on the expression of filaggerin‐2 and hornerin: Analysis of a three‐dimensional psoriatic skin model

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